Are there any known germline mutations that can dramatically reduce cancer risk?
Reddit » Genetics, genes and genomes
by /u/Unable_Quantity3753
2d ago
So I know there’s LOF mutations in genes like TP53, BRCA1/2 that can massively increase cancer risk. There’s also SNPs from various genes in GWAS studies associated with decreased risks of certain cancers, but these appear to be small decreases generally. So I’m just wondering if there’s any known mutations detected in any human that massively decrease cancer risk to the point where it would make it extremely unlikely for someone to ever get cancer. Is this theoretically possible? If not, what about something like having extra copies of tumor suppressor genes, would this decrease cancer drama ..read more
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Bananas 50% of Human DNA
Reddit » Genetics, genes and genomes
by /u/akiranazgul
2d ago
If we have such a high percentage compared to bananas, the common ancestor between us already had much of what would make us human, even before the dinosaurs, in other words, it took less time for us to differentiate 50% in recent years than billions of years to reach the 50%, right? submitted by /u/akiranazgul [visit reddit] [comments ..read more
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Question on the format of a SNP Report
Reddit » Genetics, genes and genomes
by /u/Lab_Software
2d ago
I recently had a genetic test done to determine whether I have a predisposition for Macular Degeneration (I had the test because my father had MD). For example, on a particular gene (CFH) the report lists 2 SNPs (rs3766405 and rs412852) and the findings for these are "CT" and "TT" respectively. I'm just asking about the meaning (not the significance) of the CT and TT results. For instance, does "CT" for the first SNP mean I have a C in that location on one chromosome and a T in that location on the other chromosome - or does it mean that people typically have a C in that location and I have a ..read more
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Advanced Genetics from a rare disease perspective
Reddit » Genetics, genes and genomes
by /u/SirAndys
2d ago
submitted by /u/SirAndys [visit reddit] [comments ..read more
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Do grad programs require a particular physics?
Reddit » Genetics, genes and genomes
by /u/Ok_Sun_443
2d ago
I'm an undergrad prepping my next semester schedule. My options are applied physics or physics without calculus. Does it matter which I take? I want to pursue a grad degree in genetics or computational bio submitted by /u/Ok_Sun_443 [visit reddit] [comments ..read more
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WGS Sequencing Options
Reddit » Genetics, genes and genomes
by /u/wvkid101
4d ago
Howdy! I am interested in getting a WGS ran. Most of the information I have found stems from a couple years ago. I was wondering if y'all had any recommendations of where I should get this done/things to look for in a provider in terms of getting the best product possible. I initally ordered from Dante Labs, but they have not even received my sample yet and are about to get a nice legal complaint so they are out. submitted by /u/wvkid101 [visit reddit] [comments ..read more
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I need help choosing a career
Reddit » Genetics, genes and genomes
by /u/_Deadalready
4d ago
So I have just graduated high school and genetics has been an interest of mine for a while now, and over the years I’ve reduced my options to molecular genetics and forensics. I’ve obviously researched what they do and their work hrs etc but I would really appreciate it if someone would give me both pros and cons of working in forensics and the same for molecular genetics submitted by /u/_Deadalready [visit reddit] [comments ..read more
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Yeniseians and the Karasuk Culture
Reddit » Genetics, genes and genomes
by /u/Downtown_Memory3556
4d ago
Yeniseians and the Karasuk Culture ​ According to this article, the Ket people, the only remaining Yeniseian ethnic group, are the closest genetically to the Karasuk Culture due to their ANE admixture. However, the Srubnaya component of Yeniseians is smaller than a large portion of the Siberian Turkic peoples as shown by this graph. The Karasuk Culture, however, was tested and determined to have a majority-Europoid population (according to Wikipedia). These facts seem contradictory, so could anyone explain why Kets have such high genetic affinity to the Karasuk Culture and maybe clear up some ..read more
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I need help finding my biological father
Reddit » Genetics, genes and genomes
by /u/Liveyanne
4d ago
I don’t know who my biological father is. I got a DNA test and matched with a cousin (likely first cousin we share 9.19% DNA) from my father’s side. I see her last name shared with two other relatives I have matched with. Does this mean my dad is probably her dad’s brother? Any other tips for narrowing my search down? submitted by /u/Liveyanne [visit reddit] [comments ..read more
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Was wondering if anyone knew about the beringians? I tried looking up information and youtube videos for information. Like i want to know about there dna and how it’s different.
Reddit » Genetics, genes and genomes
by /u/Key_Step7550
4d ago
submitted by /u/Key_Step7550 [visit reddit] [comments ..read more
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