Clostridioides difficile detection and infection in children: are they just small adults?
Medical Microbiology | Microbiology Society Journals | Journal of Medical Microbiology
by Sam Watkin, Francis Yongblah, James Burton, John C. Hartley and Elaine Cloutman-Green
2d ago
Clostridioides difficile is a well-recognized healthcare-associated pathogen, with its significance widely recognized in adult populations. Despite this, there is limited data on the significance of detection within paediatric populations, both for individual patient management and wider transmission risk-based considerations. High rates of colonization are understood to occur in infants, with increasing levels up to 11 months, and colonization rates similar to adults by 8 years old. Sources of C. difficile are ubiquitous, with detection in companion animals and food sources, as well as withi ..read more
Visit website
Anthraquinones against Cryptococcus neoformans sensu stricto: antifungal interaction, biofilm inhibition and pathogenicity in the Caenorhabditis elegans model
Medical Microbiology | Microbiology Society Journals | Journal of Medical Microbiology
by Géssica dos Santos Araújo, Raimunda Sâmia Nogueira Brilhante, Maria Gleiciane da Rocha, Lara de Aguiar, Débora de Souza Collares Maia Castelo-Branco, Glaucia Morgana de Melo Guedes, José Júlio Costa Sidrim, Waldemiro Aquino Pereira Neto and Marcos Fábio Gadelha Rocha
2d ago
Introduction. Cryptococcal biofilms have been associated with persistent infections and antifungal resistance. Therefore, strategies, such as the association of natural compounds and antifungal drugs, have been applied for the prevention of biofilm growth. Moreover, the Caenorhabditis elegans pathogenicity model has been used to investigate the capacity to inhibit the pathogenicity of Cryptococcus neoformans sensu stricto. Hypothesis. Anthraquinones and antifungals are associated with preventing C. neoformans sensu stricto biofilm formation and disrupting these communities. Antraquinones redu ..read more
Visit website
Performance of metagenomic next-generation sequencing in cerebrospinal fluid for diagnosis of tuberculous meningitis
Medical Microbiology | Microbiology Society Journals | Journal of Medical Microbiology
by Bi-Wei Lin, Jian-Chen Hong, Zai-Jie Jiang, Wei-Qing Zhang, Qi-Chao Fan and Xiang-Ping Yao
1w ago
Purpose. Metagenomic next-generation sequencing (mNGS) has been widely used in the diagnosis of infectious diseases, while its performance in diagnosis of tuberculous meningitis (TBM) is incompletely characterized. The aim of this study was to assess the performance of mNGS in the diagnosis of TBM, and illustrate the sensitivity and specificity of different methods. Methods. We retrospectively recruited TBM patients between January 2021 and March 2023 to evaluate the performance of mNGS on cerebrospinal fluid (CSF) samples, in comparison with conventional microbiological testing, including cu ..read more
Visit website
Delays to treatment initiation and emergence of drug resistance among new adult tuberculosis patients in Tigray, Northern Ethiopia
Medical Microbiology | Microbiology Society Journals | Journal of Medical Microbiology
by Kiros Tedla, Nega Berhe, Afework Mulugeta, Girmay Medhin, Gebretsadik Berhe, Guesh Abrha and Tilahun Teklehaymanot
1w ago
Introduction. Studies in Ethiopia have indicated that tuberculosis (TB) patient’s elapsed a long time before initiating treatment. Gap Statement. However, there is very limited evidence on the association of treatment initiation delay with drug resistance. Research Aim. To investigate the association of delayed treatment initiation with drug resistance among newly diagnosed TB patients in Tigray, Ethiopia. Methods. We conducted a follow-up study from October 2018 to June 2020 by recruiting 875 pulmonary tuberculosis (PTB) patients from 21 randomly selected health facilities. Delays to initiat ..read more
Visit website
In vitro and in silico assessment of anti-biofilm and anti-quorum sensing properties of 2,4-Di-tert butylphenol against Acinetobacter baumannii
Medical Microbiology | Microbiology Society Journals | Journal of Medical Microbiology
by Nisha Kumari Jha, Venkadesaperumal Gopu, Chandran Sivasankar, Satya Ranjan Singh, Palanisamy Bruntha Devi, Ayaluru Murali and Prathapkumar Halady Shetty
1w ago
Introduction. Acinetobacter baumannii is a nosocomial pathogen with a high potential to cause food-borne infections. It is designated as a critical pathogen by the World Health Organization due to its multi-drug resistance and mortalities reported. Biofilm governs major virulence factors, which promotes drug resistance in A. baumannii. Thus, a compound with minimum selection pressure on the pathogen can be helpful to breach biofilm-related virulence. Hypothesis/Gap Statement. To identify anti-biofilm and anti-virulent metabolites from extracts of wild Mangifera indica (mango) brine pickle bac ..read more
Visit website
Listeria monocytogenes: the silent assassin
Medical Microbiology | Microbiology Society Journals | Journal of Medical Microbiology
by Emily T. Fotopoulou, Claire Jenkins, Anaïs Painset and Corinne Amar
1w ago
Listeriosis is a foodborne infection in humans caused by Listeria monocytogenes. Consumption of contaminated food can lead to severe infection in vulnerable patients, that can be fatal. Clinical manifestations include sepsis and meningitis, and in pregnancy-associated infection, miscarriage and stillbirth. Diagnosis is confirmed by culture and identification of the pathogen from blood, cerebrospinal fluid, vaginal swab, placenta or amniotic fluid. Treatment regimens recommend amoxicillin, ampicillin or an aminoglycoside. Virulence factors mediate bacterial adhesion and invasion of gut epithel ..read more
Visit website
Novel automated antifungal susceptibility testing system for yeasts based on dual-detection algorithm of turbidimetry and colorimetry
Medical Microbiology | Microbiology Society Journals | Journal of Medical Microbiology
by Tingting Shen, Piao Liu, Dongmiao Chen, Duoduo Liu, Juan Fang, Qian Wang, Yinjuan Xu, Chunjuan Tan and Congrong Wang
3w ago
Introduction. The increasing prevalence and growing resistance of fungi present a significant peril to public health. There are only four classes of antifungal medicines available today, and few candidates are in clinical trials. Hypothesis/Gap Statement. Rapid and sensitive diagnostic techniques are lacking for most fungal pathogens, and those that do exist are expensive or hard to obtain. Aim. This study aimed to evaluate the feasibility of a novel automated antifungal susceptibility testing system, Fungus AST, in comparison to the broth microdilution method (BMD) recommended by the Clinica ..read more
Visit website
Promising activity of etomidate against mixed biofilms of fluconazole-resistant Candida albicans and methicillin-resistant Staphylococcus aureus
Medical Microbiology | Microbiology Society Journals | Journal of Medical Microbiology
by Cecília Rocha da Silva, Júlia Délis de Oliveira Rebouças, Vitória Pessoa de Farias Cabral, Daniel Sampaio Rodrigues, Amanda Dias Barbosa, Lara Elloyse Almeida Moreira, Fátima Daiana Dias Barroso, Tatiana do Nascimento Paiva Coutinho, Elaine Aires de Lima, Claudia Roberta de Andrade, João Batista de Andrade Neto, Iri Sandro Pampolha Lima, Hélio Vitoriano Nobre Júnior and Lívia Gurgel do Amaral Valente Sá
1M ago
Introduction. Candida albicans and Staphylococcus aureus are recognized for their development of resistance and biofilm formation. New therapeutic alternatives are necessary in this context. Hypothesis. Etomidate shows potential application in catheters against mixed biofilms of fluconazole-resistant C. albicans and methicillin-resistant S. aureus (MRSA). Aim. The present study aimed to evaluate the activity of etomidate against mixed biofilms of fluconazole-resistant C. albicans and MRSA. Methodology. The action of etomidate against mature biofilms was verified through the evaluation of biom ..read more
Visit website
Rapid determination of antimicrobial susceptibility of Gram-negative bacteria from clinical blood cultures using a scattered light-integrated collection device
Medical Microbiology | Microbiology Society Journals | Journal of Medical Microbiology
by Kerry Falconer, Robert Hammond, Benjamin J. Parcell and Stephen H. Gillespie
1M ago
Background. A bloodstream infection (BSI) presents a complex and serious health problem, a problem that is being exacerbated by increasing antimicrobial resistance (AMR). Gap Statement. The current turnaround times (TATs) for most antimicrobial susceptibility testing (AST) methods offer results retrospective of treatment decisions, and this limits the impact AST can have on antibiotic prescribing and patient care. Progress must be made towards rapid BSI diagnosis and AST to improve antimicrobial stewardship and reduce preventable deaths from BSIs. To support the successful implementation of r ..read more
Visit website
Genomic and metabolic versatility of Pseudomonas aeruginosa contributes to its inter-kingdom transmission and survival
Medical Microbiology | Microbiology Society Journals | Journal of Medical Microbiology
by Sakthivel Ambreetha, Diansy Zincke, Dananjeyan Balachandar and Kalai Mathee
1M ago
Pseudomonas aeruginosa is one of the most versatile bacteria with renowned pathogenicity and extensive drug resistance. The diverse habitats of this bacterium include fresh, saline and drainage waters, soil, moist surfaces, taps, showerheads, pipelines, medical implants, nematodes, insects, plants, animals, birds and humans. The arsenal of virulence factors produced by P. aeruginosa includes pyocyanin, rhamnolipids, siderophores, lytic enzymes, toxins and polysaccharides. All these virulent elements coupled with intrinsic, adaptive and acquired antibiotic resistance facilitate persistent colo ..read more
Visit website

Follow Medical Microbiology | Microbiology Society Journals | Journal of Medical Microbiology on FeedSpot

Continue with Google
Continue with Apple
OR