American Journal of Kidney Diseases
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AJKD, the official journal of the National Kidney Foundation, is recognized worldwide as a leading source of information devoted to clinical nephrology practice and clinical research.
American Journal of Kidney Diseases
1w ago
Receiving a diagnosis of chronic kidney disease (CKD) can be devasting to patients and their families. Patients with CKD and their care partners often face a lifetime of daily battles resulting from numerous symptoms and the disease’s complex pathophysiology. Many face progressive decline in kidney function and the possible need for kidney replacement therapy ..read more
American Journal of Kidney Diseases
1w ago
Advocates for improved equity in kidney transplant in the US have recently focused efforts on initiatives to increase referral for transplant evaluation. However, because donor kidneys remain scarce, increased referrals are likely to result in an increasing number of patients proceeding through the evaluation process without ultimately receiving a kidney. Unfortunately, the process of referral and evaluation can be highly resource-intensive for patients, families, transplant programs, and payers ..read more
American Journal of Kidney Diseases
1w ago
“Variability is the law of life, and as no two faces are the same, so no two bodies are alike, and no two individuals react alike and behave alike under the abnormal conditions which we know as disease…” Osler, Aequanimitas1 ..read more
American Journal of Kidney Diseases
2w ago
Less is more. Illustrations of the validity of this mantra in life and clinical medicine are not hard to find. Examples abound in the realm of critical care, such as with mechanical ventilation1 and transfusion targets.2 Perhaps the best example in critical care nephrology is in dose of continuous kidney replacement therapy (CKRT) for acute kidney injury (AKI). Early enthusiasm for the routine use of high-dose CKRT fueled by smaller single-center studies was halted by the publication in 2008 and 2009 of the VA/NIH Acute Renal Failure Trial Network (ATN) and the Randomized Evaluation ..read more
American Journal of Kidney Diseases
2w ago
APOL1 (OMIM 603743) -encoding apolipoprotein L1 (apoL1) is an evolutionarily new gene found only in humans and some primates with key roles in innate immunity against African trypanosomiasis (1) (2). Two African ancestry–related APOL1 gain-of-function haplotypes, G1 and G2, individually confer enhanced protection against human African trypanosomiasis (HAT) (3) (4). Non-G1, non-G2 haplotypes are referred to as the G0, reference or the wild-type allele (5). In a landmark discovery, the recessively inherited higher risk of chronic kidney disease (CKD) with the in-trans combinations of these two A ..read more
American Journal of Kidney Diseases
2w ago
American Journal of Kidney Diseases
2w ago
W Gong1, U Diva1, M Bensink1, X Chai2, Y Xie2, S Gao2, B Hendry1, A Mercer3, Z-Y Zhou2, B Rovin4, J Barratt5. 1Travere Therapeutics, Inc, San Diego, CA, United States; 2Analysis Group, Boston, MA, United States; 3JAMCO Pharma Consulting, Stockholm, Sweden; 4Ohio State University, Wexner Medical Center, Columbus, OH, United States; 5University of Leicester, Leicester General Hospital, Leicester, United Kingdom ..read more
American Journal of Kidney Diseases
2w ago