PMID:  Toxicology. 2024 Mar ;503:153740. Epub 2024 Feb 4. PMID: 38316350 Abstract Title:  Notoginsenoside R1 attenuates bupivacaine induced neurotoxicity by activating Jak1/Stat3/Mcl1 pathway. Abstract:  Bupivacaine, a common amide local anesthetic, can provide effective analgesia or pain relief but can also cause neurotoxicity, which remains a mounting concern in clinic and animal care. However, the precise underlying mechanisms have not been fully elucidated. A natural compound, notoginsenoside R1 (NG-R1) has been reported to exhibit a neuroprotective role in stress conditions ..read more

PMID:  J Nat Med. 2024 Feb 26. Epub 2024 Feb 26. PMID: 38409483 Abstract Title:  Integrating network pharmacology and experimental models to identify notoginsenoside R1 ameliorates atherosclerosis by inhibiting macrophage NLRP3 inflammasome activation. Abstract:  Atherosclerosis is a cardiovascular disease, accounting for the most common mortality cause worldwide. Notoginsenoside R1 (NGR1) is a characteristic saponin of Radix notoginseng that exhibits anti-inflammatory and antioxidant effects while modulating lipid metabolism. Evidence suggests that NGR1 exerts cardioprotective ..read more

PMID:  Inhal Toxicol. 2024 Mar ;36(3):145-157. Epub 2024 Feb 27. PMID: 38411938 Abstract Title:  Notoginsenoside R1 restrains the proliferation and migration of airway smooth muscle cells isolated from rats with chronic obstructive pulmonary disease. Abstract:  OBJECTIVE: Chronic obstructive pulmonary disease (COPD) is a common disorder that is characterized by systemic and lung inflammation. Notoginsenoside R1 (NGR1) displays anti-inflammatory properties in numerous diseases. We aimed to explore the function and mechanism of NGR1 in COPD.MATERIALS AND METHODS: COPD rats were es ..read more

PMID:  Phytomedicine. 2024 Apr ;126:155445. Epub 2024 Feb 10. PMID: 38412666 Abstract Title:  Notoginsenoside Fc, a novel renoprotective agent, ameliorates glomerular endothelial cells pyroptosis and mitochondrial dysfunction in diabetic nephropathy through regulating HMGCS2 pathway. Abstract:  BACKGROUND: Diabetic nephropathy (DN) is the primary cause of end-stage renal disease (ESRD), and the therapeutic strategies for DN are limited. Notoginsenoside Fc (Fc), a novel saponin isolated from Panax Notoginseng (PNG), has been reported to alleviate vascular injury in diabetic rats ..read more

PMID:  Exp Cell Res. 2024 Apr 1 ;437(1):113992. Epub 2024 Mar 16. PMID: 38492634 Abstract Title:  Notoginsenoside R1 targets PPAR-γto inhibit hepatic stellate cell activation and ameliorates liver fibrosis. Abstract:  BACKGROUND: Hepatic fibrosis, a common pathological process that occurs in end-stage liver diseases, is a serious public health problem and lacks effective therapy. Notoginsenoside R1 (NR1) is a small molecule derived from the traditional Chinese medicine Sanqi, exhibiting great potential in treating diverse metabolie disorders. Here we aimed to enquired the role o ..read more

PMID:  Phytomedicine. 2024 Jun ;128:155530. Epub 2024 Mar 11. PMID: 38493723 Abstract Title:  Notoginsenoside R1 alleviates cerebral ischemia/reperfusion injury by inhibiting the TLR4/MyD88/NF-κB signaling pathway through microbiota-gut-brain axis. Abstract:  BACKGROUND: Ischemic stroke (IS) ranks as the second common cause of death worldwide. However, a narrow thrombolysis timeframe and ischemia-reperfusion (I/R) injury limits patient recovery. Moreover, anticoagulation and antithrombotic drugs do not meet the clinical requirements. Studies have demonstrated close communication ..read more

PMID:  Mol Biotechnol. 2024 Apr 2. Epub 2024 Apr 2. PMID: 38565774 Abstract Title:  Suppression of JAK2/STAT3 Pathway by Notoginsenoside R1 Reduces Epithelial-Mesenchymal Transition in Non-small Cell Lung Cancer. Abstract:  It has bene reported that a novel saponin-notoginsenoside R1 (NGR1) possesses strong anti-tumor activities. This study aimed to investigate the role and mechanism of NGR1 in non-small cell lung cancer (NSCLC). NSCLC cell viability, proliferation, migration, and invasiveness were assessed using the ex vivo assays. NSCLC xenograft mouse models were constructed ..read more

Originally published on www.scamerica.substack.com by Alexis Baden-Mayer The overhyped threat of a human bird flu pandemic is a hoax to "reset" our food system. If the bird flu were to suddenly be transmissible from person-to-person, there would be every reason to suspect gain-of-function bioweapons research. read more ..read more

PMID:  Pharmacol Res. 2024 May 6:107203. Epub 2024 May 6. PMID: 38719196 Abstract Title:  Multi-layered effects of Panax notoginseng on immune system. Abstract:  Recent research has demonstrated the immunomodulatory potential of Panax notoginseng in the treatment of chronic inflammatory diseases and cerebral hemorrhage, suggesting its significance in clinical practice. Nevertheless, the complex immune activity of various components has hindered a comprehensive understanding of the immune-regulating properties of Panax notoginseng, impeding its broader utilization. This review ev ..read more

PMID:  Chin J Nat Med. 2024 Apr ;22(4):329-340. PMID: 38658096 Abstract Title:  Notoginsenoside Ft1 inhibits colorectal cancer growth by increasing CD8T cell proportion in tumor-bearing mice through the USP9X signaling pathway. Abstract:  The management of colorectal cancer (CRC) poses a significant challenge, necessitating the development of innovative and effective therapeutics. Our research has shown that notoginsenoside Ft1 (Ng-Ft1), a small molecule, markedly inhibits subcutaneous tumor formation in CRC and enhances the proportion of CD8T cells in tumor-bearing mice, thus r ..read more