PMID:  Support Care Cancer. 2022 Sep ;30(9):7281-7292. Epub 2022 May 21. PMID: 35596774 Abstract Title:  Role of alpha-lipoic acid in counteracting paclitaxel- and doxorubicin-induced toxicities: a randomized controlled trial in breast cancer patients. Abstract:  BACKGROUND AND OBJECTIVE: Paclitaxel and doxorubicin are associated with neurotoxicity and cardiotoxicity respectively. This study aimed at investigating the role of alpha-lipoic acid (ALA) in counteracting paclitaxel-induced neuropathy and doxorubicin-associated cardiotoxicity in women with breast cancer.PATIENTS AND M ..read more

PMID:  Sci Rep. 2022 Jan 7 ;12(1):271. Epub 2022 Jan 7. PMID: 34997178 Abstract Title:  The beneficial effect of Alpha-lipoic acid supplementation as a potential adjunct treatment in episodic migraines. Abstract:  The current study was performed to evaluate the effects of alpha-lipoic acid (ALA) supplementation on lactate, nitric oxide (NO), vascular cell adhesion molecule-1 (VCAM-1) levels, and clinical symptoms in women with episodic migraines. Considering the inclusion and exclusion criteria, ninety-two women with episodic migraines participated in this randomized, double-bli ..read more

PMID:  Eur Rev Med Pharmacol Sci. 2022 Apr ;26(7):2313-2329. PMID: 35442486 Abstract Title:  Alpha-lipoic acid improved anemia, erythropoietin resistance, maintained glycemic control, and reduced cardiovascular risk in diabetic patients on hemodialysis: a multi-center prospective randomized controlled study. Abstract:  OBJECTIVE: To investigate the impact of alpha-lipoic acid (ALA) on inflammation, oxidative stress, anemia, and glycemic parameters and their association with cardiovascular risk in diabetic patients on hemodialysis.PATIENTS AND METHODS: In this multi-center, rando ..read more

PMID:  Int J Fertil Steril. 2023 Jan 1 ;17(1):67-74. Epub 2023 Jan 1. PMID: 36617206 Abstract Title:  Alpha-Lipoic Acid Supplementation for Male Partner of Couples with Recurrent Pregnancy Loss: A Post hoc analysis in Clinical Trial. Abstract:  BACKGROUND: Increased sperm DNA damage is known as one of the causes of recurrent pregnancy loss (RPL) which can be due to increased levels of oxidative stress. Therefore, the aim of this study was to assess the effect of alpha-lipoic acid (ALA) on sperm parameters and sperm functions in couples with a history of RPL.MATERIALS AND METHODS ..read more

PMID:  J Clin Pharmacol. 2023 Dec ;63(12):1398-1407. Epub 2023 Aug 24. PMID: 37563914 Abstract Title:  Evaluation of Safety and Efficacy of Add-on Alpha-Lipoic Acid on Migraine Prophylaxis in an Adolescent Population: A Randomized Controlled Trial. Abstract:  Nutraceuticals like alpha-lipoic acid (ALA) may have potential benefits as prophylactic agents for adolescent migraine, with fewer adverse events than existing medications. The present study was conducted to evaluate the safety and efficacy of add-on ALA for prophylaxis in adolescent migraine. A randomized, open-label, add ..read more

PMID:  Cell Biochem Biophys. 2024 Jan 23. Epub 2024 Jan 23. PMID: 38261247 Abstract Title:  Alpha-lipoic Acid Prevents Bone Loss in Type 2 Diabetes and Postmenopausal Osteoporosis Coexisting Conditions by Modulating the YAP/Glut4 Pathway. Abstract:  This study aims to characterize the bone-protecting effects of Alpha-lipoic acid (ALA), a potent antioxidant, against the detrimental effects of the coexistence of type 2 diabetes mellitus (T2DM) and postmenopausal osteoporosis (POP) and identify the possible mechanisms with particular reference to its modulation of YAP/Glut4 pathway ..read more

PMID:  Muscle Nerve. 2024 Apr ;69(4):498-503. Epub 2024 Jan 31. PMID: 38294129 Abstract Title:  Protective effect of alpha-lipoic acid and epalrestat on oxaliplatin-induced peripheral neuropathy in zebrafish. Abstract:  INTRODUCTION/AIMS: Oxaliplatin is a platinum-based anti-cancer drug widely used in colorectal cancer patients, but it may cause peripheral neuropathy. As one of the main causes of oxaliplatin-induced peripheral neuropathy (OPN) is oxidative stress, which is also a key factor causing diabetic peripheral neuropathy (DPN), the aim of this study was to evaluate the p ..read more

PMID:  Neuroreport. 2024 Mar 6 ;35(4):250-257. Epub 2024 Jan 15. PMID: 38305103 Abstract Title:  Alpha-lipoic acid (ALA) ameliorates early brain injury after subarachnoid hemorrhage in Sprague-Dawley (SD) rats via inhibiting STING-NLRP3 inflammatory signaling. Abstract:  Neuroinflammation is intimately associated with poor prognosis in patients with subarachnoid hemorrhage (SAH). Alpha-lipoic acid (ALA), a disulfide antioxidant, has been shown to be neuroprotective in an in vivo model of neurological injury; however, the role of ALA in SAH has never been evaluated. In this study ..read more

PMID:  Sci Total Environ. 2024 Mar 25 ;918:170700. Epub 2024 Feb 6. PMID: 38331288 Abstract Title:  Polystyrene nanoplastics inhibit beige fat function and exacerbate metabolic disorder in high-fat diet-fed mice. Abstract:  Global health concerns about micro- and nanoplastics are increasing. The newly discovered beige adipocytes play a vital role in energy homeostasis through their high thermogenic capacity upon activation. However, the effects of micro- and nanoplastics on beige adipocytes have not yet been studied. We investigated whether the effects of oral exposure to polyst ..read more

PMID:  Environ Toxicol Pharmacol. 2024 Mar ;106:104385. Epub 2024 Feb 8. PMID: 38340909 Abstract Title:  Oxidative stress-activated Nrf2 remitted polystyrene nanoplastic-induced mitochondrial damage and inflammatory response in HepG2 cells. Abstract:  Generated from plastics, microplastics (MPs) and nanoplastics (NPs) are difficult to completely degrade in the natural environment, which can accumulate in almost all lives. Liver is one of the main target organs. In this study, HepG2 and L02 cells were exposed to 0-50 μg/mL polystyrene (PS)-NPs to investigate the mechanism of mito ..read more