Nature Immunology
61 FOLLOWERS
Nature Immunology is a multidisciplinary journal that publishes papers of the highest quality and significance in all areas of immunology. Priority is given to work that provides fundamental insight into the workings of the immune system.
Nature Immunology
4d ago
Nature Immunology, Published online: 12 April 2024; doi:10.1038/s41590-024-01817-w
Here, the authors describe biallelic loss-of-function variants in human SHARPIN in individuals with autoinflammation and immunodeficiency, termed sharpenia. They also successfully treat one of these individuals with TNF inhibitors ..read more
Nature Immunology
4d ago
Nature Immunology, Published online: 12 April 2024; doi:10.1038/s41590-024-01814-z
In this Resource, the authors integrate multiomics data to show the effect of the transcription factors Blimp-1 and c-Maf on IL-10 and type 1 and 17 responses, which together protect against pathobiont-induced colitis ..read more
Nature Immunology
4d ago
Nature Immunology, Published online: 10 April 2024; doi:10.1038/s41590-024-01808-x
Cupedo and colleagues show that neutrophils promote a tumor-supportive microenvironment via a self-amplifying interaction between neutrophils and bone marrow stromal cells. This scenario creates a promyeloma niche that is difficult to treat despite targeted therapies directed at the myeloma cells ..read more
Nature Immunology
4d ago
Nature Immunology, Published online: 10 April 2024; doi:10.1038/s41590-024-01810-3
Inflammatory memory cues initiated by neutrophils and bone marrow stroma suggest potential therapeutic targets for the treatment of multiple myeloma ..read more
Nature Immunology
1w ago
Nature Immunology, Published online: 08 April 2024; doi:10.1038/s41590-024-01778-0
Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized ..read more
Nature Immunology
1w ago
Nature Immunology, Published online: 08 April 2024; doi:10.1038/s41590-024-01803-2
Kratchmarov et al. identified a GATA3+ TH2 population that expresses the transcription factors TCF1 and LEF1 and sustains type 2 inflammation in tissues over a human lifetime, despite chronic antigen exposure ..read more
Nature Immunology
1w ago
Nature Immunology, Published online: 08 April 2024; doi:10.1038/s41590-024-01811-2
Here the authors identify the transcription factor MEF2C as essential for human NK cell function and viral immunity in mice and humans. This control is exerted via regulation of lipid metabolism, and deficiency in MEF2C can be overcome by oleic acid supplementation ..read more
Nature Immunology
2w ago
Nature Immunology, Published online: 01 April 2024; doi:10.1038/s41590-024-01802-3
CD103+ T cells are associated with control over tumors but how this is mediated is unclear. Here the authors show that CD61 colocalizes and functionally combines with CD103 in the T cell synaptic response to promote antitumor T cell responses ..read more
Nature Immunology
2w ago
Nature Immunology, Published online: 29 March 2024; doi:10.1038/s41590-024-01798-w
Here the authors show a mechanism by which mitochondrial electron transport and ROS contribute to the differentiation and function of regulatory B cells in the context of systemic lupus erythematosus ..read more
Nature Immunology
2w ago
Nature Immunology, Published online: 22 March 2024; doi:10.1038/s41590-024-01786-0
Autoantibodies that develop in systemic lupus erythematosus (SLE) can cause long-term cognitive impairment that remains even after the systemic disease becomes quiescent. This study attributes the persistent cognitive symptoms of SLE to a self-sustaining neuroinflammatory process that continues indefinitely unless disrupted — which can be done using medications approved by the US Food and Drug Administration ..read more