Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency
Nature Immunology
by Hirotsugu Oda, Kalpana Manthiram, Pallavi Pimpale Chavan, Eva Rieser, Önay Veli, Öykü Kaya, Charles Rauch, Shuichiro Nakabo, Hye Sun Kuehn, Mariël Swart, Yanli Wang, Nisa Ilgim Çelik, Anne Molitor, Vahid Ziaee, Nasim Movahedi, Mohammad Shahrooei, Nima Parvaneh, Nasrin Alipour-olyei, Raphael Carapito, Qin Xu, Silvia Preite, David B. Beck, Jae Jin Chae, Michele Nehrebecky, Amanda K. Ombrello, Patrycja Hoffmann, Tina Romeo, Natalie T. Deuitch, Brynja Matthíasardóttir, James Mullikin, Hirsh Komarow, Jennifer Stoddard, Julie Niemela, Kerry Dobbs, Colin L. Sweeney, Holly Anderton, Kate E. Lawlor, Hiroyuki Yoshitomi, Dan Yang, Manfred Boehm, Jeremy Davis, Pamela Mudd, Davide Randazzo, Wanxia Li Tsai, Massimo Gadina, Mariana J. Kaplan, Junya Toguchida, Christian T. Mayer, Sergio D. Rosenzweig, Luigi D. Notarangelo, Kazuhiro Iwai, John Silke, Pamela L. Schwartzberg, Bertrand Boisson, Jean-Laurent Casanova, Seiamak Bahram, Anand Prahalad Rao, Nieves Peltzer, Henning Walczak, Najoua Lalaoui, Ivona Aksentijevich, Daniel L. Kastner
4d ago
Nature Immunology, Published online: 12 April 2024; doi:10.1038/s41590-024-01817-w Here, the authors describe biallelic loss-of-function variants in human SHARPIN in individuals with autoinflammation and immunodeficiency, termed sharpenia. They also successfully treat one of these individuals with TNF inhibitors ..read more
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Blimp-1 and c-Maf regulate immune gene networks to protect against distinct pathways of pathobiont-induced colitis
Nature Immunology
by Marisol Alvarez-Martinez, Luke S. Cox, Claire F. Pearson, William J. Branchett, Probir Chakravarty, Xuemei Wu, Hubert Slawinski, Alaa Al-Dibouni, Vasileios A. Samelis, Leona Gabryšová, Simon L. Priestnall, Alejandro Suárez-Bonnet, Anna Mikolajczak, James Briscoe, Fiona Powrie, Anne O’Garra
4d ago
Nature Immunology, Published online: 12 April 2024; doi:10.1038/s41590-024-01814-z In this Resource, the authors integrate multiomics data to show the effect of the transcription factors Blimp-1 and c-Maf on IL-10 and type 1 and 17 responses, which together protect against pathobiont-induced colitis ..read more
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An IL-1β-driven neutrophil–stromal cell axis fosters a BAFF-rich protumor microenvironment in individuals with multiple myeloma
Nature Immunology
by Madelon M. E. de Jong, Cathelijne Fokkema, Natalie Papazian, Ágnes Czeti, Marjolein K. Appelman, Michael Vermeulen, Teddie van Heusden, Remco M. Hoogenboezem, Gregory van Beek, Sabrin Tahri, Mathijs A. Sanders, Pieter C. van de Woestijne, Francesca Gay, Philippe Moreau, Maike Büttner-Herold, Heiko Bruns, Mark van Duin, Annemiek Broijl, Pieter Sonneveld, Tom Cupedo
4d ago
Nature Immunology, Published online: 10 April 2024; doi:10.1038/s41590-024-01808-x Cupedo and colleagues show that neutrophils promote a tumor-supportive microenvironment via a self-amplifying interaction between neutrophils and bone marrow stromal cells. This scenario creates a promyeloma niche that is difficult to treat despite targeted therapies directed at the myeloma cells ..read more
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The enduring neutrophil–stroma dance of multiple myeloma
Nature Immunology
by Daniela Cerezo-Wallis, Iván Ballesteros
4d ago
Nature Immunology, Published online: 10 April 2024; doi:10.1038/s41590-024-01810-3 Inflammatory memory cues initiated by neutrophils and bone marrow stroma suggest potential therapeutic targets for the treatment of multiple myeloma ..read more
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Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease
Nature Immunology
by Felicity Liew, Claudia Efstathiou, Sara Fontanella, Matthew Richardson, Ruth Saunders, Dawid Swieboda, Jasmin K. Sidhu, Stephanie Ascough, Shona C. Moore, Noura Mohamed, Jose Nunag, Clara King, Olivia C. Leavy, Omer Elneima, Hamish J. C. McAuley, Aarti Shikotra, Amisha Singapuri, Marco Sereno, Victoria C. Harris, Linzy Houchen-Wolloff, Neil J. Greening, Nazir I. Lone, Matthew Thorpe, A. A. Roger Thompson, Sarah L. Rowland-Jones, Annemarie B. Docherty, James D. Chalmers, Ling-Pei Ho, Alexander Horsley, Betty Raman, Krisnah Poinasamy, Michael Marks, Onn Min Kon, Luke S. Howard, Daniel G. Wootton, Jennifer K. Quint, Thushan I. de Silva, Antonia Ho, Christopher Chiu, Ewen M. Harrison, William Greenhalf, J. Kenneth Baillie, Malcolm G. Semple, Lance Turtle, Rachael A. Evans, Louise V. Wain, Christopher Brightling, Ryan S. Thwaites, Peter J. M. Openshaw, Kathryn Abel, H. Adamali, Davies Adeloye, Oluwaseun Adeyemi, Rita Adrego, Laura Aguilar Jimenez, Shanaz Ahmad, N. Ahmad Haider, Rubina Ahmed, Nyarko Ahwireng, Mark Ainsworth, Asma Alamoudi, Mariam Ali, M. Aljaroof, Louise Allan, Richard Allen, Lisa Allerton, Lynne Allsop, Ann Marie Allt, Paula Almeida, Bashar Al-Sheklly, Danny Altmann, Maria Alvarez Corral, Shannon Amoils, David Anderson, Charalambos Antoniades, Gill Arbane, Ava Maria Arias, Cherie Armour, Lisa Armstrong, Natalie Armstrong, David Arnold, H. Arnold, A. Ashish, Andrew Ashworth, M. Ashworth, Shahab Aslani, Hosanna Assefa-Kebede, Paul Atkin, Catherine Atkin, Raminder Aul, Hnin Aung, Liam Austin, Cristina Avram, Nikos Avramidis, A. Ayoub, Marta Babores, Rhiannon Baggott, J. Bagshaw, David Baguley, Elisabeth Bailey, Steve Bain, Majda Bakali, M. Bakau, E. Baldry, Molly Baldwin, David Baldwin, Clive Ballard, Amita Banerjee, Dongchun Bang, R. E. Barker, Laura Barman, Perdita Barran, Shaney Barratt, Fiona Barrett, Donna Basire, Neil Basu, Michelle Bates, A. Bates, R. Batterham, Helen Baxendale, Gabrielle Baxter, Hannah Bayes, M. Beadsworth, Paul Beckett, M. Beggs, M. Begum, Paul Beirne, Murdina Bell, Robert Bell, Kaytie Bennett, Eva Beranova, Areti Bermperi, Anthony Berridge, Colin Berry, Sarah Betts, Emily Bevan, Kamaldeep Bhui, Michelle Bingham, K. Birchall, Lettie Bishop, Karen Bisnauthsing, John Blaikely, Angela Bloss, Annette Bolger, Charlotte Bolton, J. Bonnington, A. Botkai, Charlotte Bourne, Michelle Bourne, Kate Bramham, Lucy Brear, G. Breen, Jonathon Breeze, Katie Breeze, Andrew Briggs, E. Bright, Simon Brill, K. Brindle, Lauren Broad, Andrew Broadley, Claire Brookes, Mattew Broome, Vanessa Brown, M. Brown, Jo Brown, J. Brown, Ammani Brown, Angela Brown, Jeremy Brown, Terry Brugha, Nigel Brunskill, M. Buch, Phil Buckley, Anda Bularga, Ed Bullmore, Jenny Bunker, L. Burden, Tracy Burdett, David Burn, G. Burns, A. Burns, John Busby, Robyn Butcher, Al-Tahoor Butt, S. Byrne, P. Cairns, P. C. Calder, Ellen Calvelo, H. Carborn, Bethany Card, Caitlin Carr, Liesel Carr, G. Carson, Penny Carter, Anna Casey, M. Cassar, Jonathon Cavanagh, Manish Chablani, Trudie Chalder, Rachel Chambers, Flora Chan, K. M. Channon, Kerry Chapman, Amanda Charalambou, N. Chaudhuri, A. Checkley, Jin Chen, Yutung Cheng, Luke Chetham, Caroline Childs, Edwin Chilvers, H. Chinoy, A. Chiribiri, K. Chong-James, N. Choudhury, Gaunab Choudhury, Phillip Chowienczyk, C. Christie, Melanie Chrystal, Cameron Clark, David Clark, Jude Clarke, S. Clohisey, G. Coakley, Zach Coburn, S. Coetzee, Joby Cole, Chris Coleman, Florence Conneh, David Connell, Bronwen Connolly, Lynda Connor, Amanda Cook, Shirley Cooper, B. Cooper, Josh Cooper, Donna Copeland, Tracey Cosier, Eamon Coughlan, Martina Coulding, C. Coupland, E. Cox, Thelma Craig, P. Crisp, Daniele Cristiano, Michael Crooks, Andy Cross, Isabel Cruz, P. Cullinan, D. Cuthbertson, Luke Daines, Matthhew Dalton, Patrick Daly, Alison Daniels, P. Dark, Joanne Dasgin, C. David, Anthony David, Ffyon Davies, Ellie Davies, Kim Davies, Gareth Davies, Gwyneth Davies, Melanie Davies, Joy Dawson, Camilla Dawson, Enya Daynes, Anthony De Soyza, Bill Deakin, Andrew Deans, C. Deas, Joanne Deery, Sylviane Defres, Amanda Dell, K. Dempsey, Emma Denneny, J. Dennis, A. Dewar, Ruvini Dharmagunawardena, Nawar Diar-Bakerly, Caroline Dickens, A. Dipper, Sarah Diver, Shalin Diwanji, Myles Dixon, R. Djukanovic, Hannah Dobson, S. L. Dobson, A. Donaldson, T. Dong, N. Dormand, Andrew Dougherty, Rachael Dowling, Stephen Drain, Katharine Draxlbauer, Katie Drury, Pearl Dulawan, A. Dunleavy, Sarah Dunn, Catherine Dupont, Joanne Earley, Nicholas Easom, Carlos Echevarria, Sarah Edwards, C. Edwardson, Anne Elliott, K. Elliott, Yvette Ellis, Anne Elmer, Hosni El-Taweel, Teriann Evans, Ranuromanana Evans, D. Evans, R. Evans, H. Evans, Jonathon Evans, Cerys Evenden, Lynsey Evison, Laura Fabbri, Sara Fairbairn, Alexandra Fairman, K. Fallon, David Faluyi, Clair Favager, Tamanah Fayzan, James Featherstone, T. Felton, V. Ferreira, J. Finch, Selina Finney, J. Finnigan, L. Finnigan, Helen Fisher, S. Fletcher, Rachel Flockton, Margaret Flynn, H. Foot, David Foote, Amber Ford, D. Forton, Eva Fraile, C. Francis, Richard Francis, Susan Francis, Anew Frankel, Emily Fraser, Rob Free, N. French, X. Fu, Jonathon Fuld, J. Furniss, Lucie Garner, N. Gautam, John Geddes, J. George, P. George, Michael Gibbons, Rhyan Gill, Mandy Gill, L. Gilmour, F. Gleeson, Jodie Glossop, Sarah Glover, Nicola Goodman, Camelia Goodwin, Bibek Gooptu, Hussain Gordon, T. Gorsuch, M. Greatorex, Paul Greenhaff, Alan Greenhalgh, John Greenwood, Rebecca Gregory, Heidi Gregory, D. Grieve, Denise Griffin, L. Griffiths, Anne-Marie Guerdette, Beatriz Guillen-Guio, Mahitha Gummadi, Ayushman Gupta, Sambasivarao Gurram, Elspeth Guthrie, Zoe Guy, Kate Hadley, Ahmed Haggar, Kera Hainey, Brigid Hairsine, Pranab Haldar, Lucy Hall, Ian Hall, Mark Halling-Brown, R. Hamil, Alyson Hancock, Kia Hancock, Neil Hanley, Sulaimaan Haq, Hayley Hardwick, Tim Hardy, E. Hardy, Beverley Hargadon, Kate Harrington, Edward Harris, Ewen Harrison, Paul Harrison, Nicholas Hart, Alice Harvey, Matt Harvey, M. Harvie, L. Haslam, Claire Hastie, May Havinden-Williams, Jenny Hawkes, Nancy Hawkings, Jill Haworth, A. Hayday, Matthew Haynes, J. Hazeldine, Tracy Hazelton, Liam Heaney, Cheryl Heeley, Jonathon Heeney, M. Heightman, Simon Heller, Max Henderson, Helen Henson, L. Hesselden, Melanie Hewitt, Victoria Highett, T. Hillman, T. Hiwot, Michaela Hoare, Amy Hoare, J. Hockridge, Philip Hogarth, Ailsa Holbourn, Sophie Holden, L. Holdsworth, D. Holgate, Maureen Holland, Leah Holloway, Katie Holmes, Megan Holmes, B. Holroyd-Hind, L. Holt, Anil Hormis, Akram Hosseini, M. Hotopf, Kate Howard, Alice Howell, E. Hufton, Rachel Ann Hughes, Joan Hughes, Alun Hughes, Amy Humphries, Nathan Huneke, E. Hurditch, John Hurst, Masud Husain, Tracy Hussell, John Hutchinson, W. Ibrahim, F. Ilyas, Julie Ingham, L. Ingram, Diana Ionita, Karen Isaacs, Khalida Ismail, T. Jackson, Joseph Jacob, W. Y. James, W. Jang, Claire Jarman, Ian Jarrold, Hannah Jarvis, Roman Jastrub, Bhagy Jayaraman, Gisli Jenkins, P. Jezzard, Kasim Jiwa, C. Johnson, Simon Johnson, Desmond Johnston, Caroline Jolley, S. Jones, H. Jones, L. Jones, Ian Jones, G. Jones, Heather Jones, Mark Jones, Don Jones, Sherly Jose, Thomas Kabir, G. Kaltsakas, Vicky Kamwa, N. Kanellakis, Sabina Kaprowska, Zunaira Kausar, Natalie Keenan, S. Kelly, G. Kemp, Steven Kerr, Helen Kerslake, Angela Key, Fasih Khan, Kamlesh Khunti, Susan Kilroy, Bernie King, Lucy Kingham, Jill Kirk, Paaig Kitterick, Paul Klenerman, Lucy Knibbs, Sean Knight, Abigail Knighton, S. Kon, Samantha Kon, Ania Korszun, Ivan Koychev, Claire Kurasz, Prathiba Kurupati, C. Laing, Hanan Lamlum, G. Landers, Claudia Langenberg, Lara Lavelle-Langham, Allan Lawrie, Cathy Lawson, Claire Lawson, Alison Layton, A. Lea, Ju Hee Lee, Elvina Lee, D. Lee, Karen Leitch, Rebecca Lenagh, Victoria Lewis, Joanne Lewis, Keir Lewis, D. Lewis, N. Lewis-Burke, X. Li, Tessa Light, Liz Lightstone, W. Lilaonitkul, Lai Lim, S. Linford, Anne Lingford-Hughes, M. Lipman, Kamal Liyanage, Arwel Lloyd, S. Logan, D. Lomas, Ronda Loosley, Janet Lord, Harpreet Lota, Wayne Lovegrove, Daniel Lozano-Rojas, Alice Lucey, Gardiner Lucy, E. Lukaschuk, Alison Lye, Ceri Lynch, S. MacDonald, G. MacGowan, Irene Macharia, J. Mackie, L. Macliver, S. Madathil, Gladys Madzamba, Nick Magee, Murphy Magtoto, N. Mairs, N. Majeed, E. Major, Flora Malein, M. Malim, Georgia Mallison, William Man, S. Mandal, K. Mangion, C. Manisty, R. Manley, Katherine March, Stefan Marciniak, Philip Marino, Myril Mariveles, Elizabeth Marouzet, Sophie Marsh, M. Marshall, B. Marshall, Jane Martin, Adrian Martineau, L. M. Martinez, Nick Maskell, Darwin Matila, Wadzanai Matimba-Mupaya, Laura Matthews, Angeline Mbuyisa, Steve McAdoo, Hamish McAllister-Williams, Paul McArdle, Anne McArdle, Danny McAulay, Gerry McCann, W. McCormick, Jacqueline McCormick, P. McCourt, Celeste McCracken, Lorcan McGarvey, C. McGee, K. Mcgee, Jade McGinness, K. McGlynn, Andrew McGovern, Heather McGuinness, I. B. McInnes, Jerome McIntosh, Emma McIvor, Katherine McIvor, Laura McLeavey, Aisling McMahon, Michael McMahon, L. McMorrow, Teresa Mcnally, M. McNarry, J. McNeill, Alison McQueen, H. McShane, Chloe Mears, Clare Megson, Sharon Megson, P. Mehta, J. Meiring, Lucy Melling, Mark Mencias, R. Menke, Daniel Menzies, Marta Merida Morillas, Alice Michael, Benedict Michael, C. A. Miller, Lea Milligan, Nicholas Mills, Clare Mills, George Mills, L. Milner, S. Misra, Jane Mitchell, Abdelrahman Mohamed, S. Mohammed, Philip Molyneaux, Will Monteiro, Silvia Moriera, Anna Morley, Leigh Morrison, Richard Morriss, A. Morrow, Paul Moss, Alistair Moss, K. Motohashi, N. Msimanga, Elizabeta Mukaetova-Ladinska, Unber Munawar, Jennifer Murira, Uttam Nanda, Heeah Nassa, Mariam Nasseri, Rashmita Nathu, Aoife Neal, Robert Needham, Paula Neill, Stefan Neubauer, D. E. Newby, Helen Newell, J. Newman, Tom Newman, Alex Newton-Cox, T. E. Nichols, Tim Nicholson, Christos Nicolaou, Debby Nicoll, Athanasios Nikolaidis, C. Nikolaidou, C. M. Nolan, Matthew Noonan, C. Norman, Petr Novotny, Kimon Ntotsis, Lorenza Nwafor, Uchechi Nwanguma, Joseph Nyaboko, Linda O’Brien, C. O’Brien, Natasha Odell, Kate O’Donnell, Godwin Ogbole, G. Ogg, Olaoluwa Olaosebikan, Catherine Oliver, Zohra Omar, D. P. O’Regan, Lorna Orriss-Dib, Lynn Osborne, Rebecca Osbourne, Marlies Ostermann, Charlotte Overton, J. Owen, J. Oxton, Jamie Pack, Edmund Pacpaco, Stella-Maria Paddick, Sharon Painter, Erola Pairo-Castineira, Ashkan Pakzad, Sue Palmer, Padmasayee Papineni, K. Paques, Kerry Paradowski, Manish Pareek, Dhruv Parekh, H. Parfrey, Carmen Pariante, S. Parker, M. Parkes, J. Parmar, Sheetal Patale, Manish Patel, B. Patel, Suhani Patel, Dibya Pattenadk, M. Pavlides, Sheila Payne, Lorraine Pearce, John Pearl, Dan Peckham, Jessica Pendlebury, Yanchun Peng, Chris Pennington, Ida Peralta, Emma Perkins, Z. Peterkin, Tunde Peto, Nayia Petousi, John Petrie, Paul Pfeffer, Janet Phipps, S. Piechnik, John Pimm, Karen Piper Hanley, Riinu Pius, Hannah Plant, S. Plein, Tatiana Plekhanova, Megan Plowright, Oliver Polgar, L. Poll, Julie Porter, Joanna Porter, Sofiya Portukhay, Natassia Powell, A. Prabhu, James Pratt, Andrea Price, Claire Price, Carly Price, L. Price, D. Price, Anne Prickett, I. Propescu, J. Propescu, Sabrina Prosper, S. Pugmire, Sheena Quaid, Jackie Quigley, H. Qureshi, I. N. Qureshi, K. Radhakrishnan, Najib Rahman, Markus Ralser, Hazel Ramos, Albert Ramos, Jade Rangeley, Bojidar Rangelov, Liz Ratcliffe, Phillip Ravencroft, Konrad Rawlik, Anne Reddington, R. Reddy, A. Reddy, Heidi Redfearn, Dawn Redwood, Annabel Reed, Meryl Rees, Tabitha Rees, Karen Regan, Will Reynolds, Carla Ribeiro, A. Richards, Emma Richardson, M. Richardson, Pilar Rivera-Ortega, K. Roberts, Elizabeth Robertson, Leanne Robinson, Emma Robinson, Lisa Roche, C. Roddis, J. Rodger, Natalie Rogers, Gavin Ross, Alexandra Ross, Jennifer Rossdale, Anthony Rostron, Anna Rowe, J. Rowland, M. J. Rowland, A. Rowland, Maura Roy, K. Roy, Igor Rudan, Richard Russell, Emily Russell, Gwen Saalmink, Ramsey Sabit, Beth Sage, T. Samakomva, Nilesh Samani, A. A. Samat, Claire Sampson, Katherine Samuel, Reena Samuel, Z. B. Sanders, Amy Sanderson, Elizabeth Sapey, Dinesh Saralaya, Jack Sargant, Carol Sarginson, T. Sass, Naveed Sattar, Kathryn Saunders, Peter Saunders, Laura Saunders, Heather Savill, W. Saxon, Avan Sayer, J. Schronce, William Schwaeble, Janet Scott, Kathryn Scott, Nick Selby, Terri Ann Sewell, Kamini Shah, Ajay Shah, P. Shah, Manu Shankar-Hari, M. Sharma, Claire Sharpe, Michael Sharpe, Sharlene Shashaa, Alison Shaw, Victoria Shaw, Karen Shaw, Aziz Sheikh, Sarah Shelton, Liz Shenton, K. Shevket, J. Short, Sulman Siddique, Salman Siddiqui, J. Sidebottom, Louise Sigfrid, Gemma Simons, Neil Simpson, John Simpson, Ananga Singapuri, Suver Singh, Claire Singh, Sally Singh, D. Sissons, J. Skeemer, Katie Slack, David Smith, Nikki Smith, Andrew Smith, Jacqui Smith, Laurie Smith, Susan Smith, M. Soares, Teresa Solano, Reanne Solly, A. R. Solstice, Tracy Soulsby, David Southern, D. Sowter, Mark Spears, Lisa Spencer, Fabio Speranza, Louise Stadon, Stefan Stanel, R. Steeds, N. Steele, Mike Steiner, David Stensel, G. Stephens, Lorraine Stephenson, M. Stern, Iain Stewart, R. Stimpson, Sue Stockdale, J. Stockley, Wendy Stoker, Roisin Stone, Will Storrar, Andrew Storrie, Kim Storton, E. Stringer, Sophia Strong-Sheldrake, Natalie Stroud, Christian Subbe, Catherine Sudlow, Zehra Suleiman, Charlotte Summers, C. Summersgill, Debbie Sutherland, D. L. Sykes, R. Sykes, Nick Talbot, Ai Lyn Tan, Lawrence Tarusan, Vera Tavoukjian, Jessica Taylor, Abigail Taylor, Chris Taylor, John Paul Taylor, Amelie Te, H. Tedd, Caroline Tee, J. Teixeira, Helen Tench, Sarah Terry, Susannah Thackray-Nocera, Favas Thaivalappil, B. Thamu, David Thickett, David Thomas, S. Thomas, Caradog Thomas, Andrew Thomas, T. Thomas-Woods, Tamika Thompson, T. Thornton, Jo Tilley, N. Tinker, Gerlynn Tiongson, Martin Tobin, Johanne Tomlinson, C. Tong, Mark Toshner, R. Touyz, T. Treibel, K. A. Tripp, Drupad Trivedi, E. M. Tunnicliffe, Alison Turnbull, Kim Turner, Sarah Turner, Victoria Turner, E. Turner, Sharon Turney, Helena Turton, Jacinta Ugoji, R. Ugwuoke, Rachel Upthegrove, Jonathon Valabhji, Maximina Ventura, Joanne Vere, Carinna Vickers, Ben Vinson, Ioannis Vogiatzis, Elaine Wade, Phillip Wade, Tania Wainwright, Lilian Wajero, Sinead Walder, Samantha Walker, S. Walker, E. Wall, Tim Wallis, Sarah Walmsley, Simon Walsh, J. A. Walsh, Louise Warburton, T. J. C. 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Ahmed, Dhiraj Ail, Erin L. Aldera, Ana Alegria, Beatrice Alex, Sam Allen, Petros Andrikopoulos, Brian Angus, Jane A. Armstrong, Abdul Ashish, Milton Ashworth, Innocent G. Asiimwe, Dougal Atkinson, Benjamin Bach, Siddharth Bakshi, Wendy S. Barclay, Shahedal Bari, Gavin Barlow, Samantha L. Barlow, Stella Barnass, Nicholas Barrett, Christopher Bassford, Sneha Basude, David Baxter, Michael Beadsworth, Jolanta Bernatoniene, John Berridge, Nicola Best, Debby Bogaert, Laura Booth, Pieter Bothma, Benjamin Brennan, Robin Brittain-Long, Katie Bullock, Naomi Bulteel, Tom Burden, Andrew Burtenshaw, Nicola Carlucci, Gail Carson, Vikki Caruth, Emily Cass, Benjamin W. A. Catterall, David Chadwick, Duncan Chambler, Meera Chand, Kanta Chechi, Nigel Chee, Jenny Child, Srikanth Chukkambotla, Richard Clark, Tom Clark, Jordan J. Clark, Emily A. Clarke, Sara Clohisey, Sarah Cole, Paul Collini, Marie Connor, Graham S. 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Miah, Joanna Middleton, Gary Mills, Jane Minton, Joyce Mitchell, Kavya Mohandas, Quen Mok, James Moon, Elinoor Moore, Patrick Morgan, Kirstie Morrice, Craig Morris, Katherine Mortimore, Samuel Moses, Mbiye Mpenge, Rohinton Mulla, Derek Murphy, Lee Murphy, Michael Murphy, Ellen G. Murphy, Thapas Nagarajan, Megan Nagel, Mark Nelson, Lisa Norman, Lillian Norris, Lucy Norris, Mahdad Noursadeghi, Michael Olanipekun, Wilna Oosthuyzen, Anthonia Osagie, Matthew K. O’Shea, Igor Otahal, Mark Pais, Massimo Palmarini, Carlo Palmieri, Selva Panchatsharam, Danai Papakonstantinou, Hassan Paraiso, Brij Patel, Natalie Pattison, William A. Paxton, Rebekah Penrice-Randal, Justin Pepperell, Mark Peters, Mandeep Phull, Jack Pilgrim, Stefania Pintus, Tim Planche, Daniel Plotkin, Georgios Pollakis, Frank Post, Nicholas Price, David Price, Tessa Prince, Rachel Prout, Nikolas Rae, Andrew Rambaut, Henrik Reschreiter, Tim Reynolds, Neil Richardson, P. Matthew Ridley, Mark Roberts, Stephanie Roberts, Devender Roberts, David L. Robertson, Alistair Rose, Guy Rousseau, Bobby Ruge, Clark D. Russell, Brendan Ryan, Debby Sales, Taranprit Saluja, Vanessa Sancho-Shimizu, Caroline Sands, Egle Saviciute, Matthias Schmid, Janet T. Scott, James Scott-Brown, Aarti Shah, Prad Shanmuga, Anil Sharma, Catherine A. Shaw, Victoria E. Shaw, Anna Shawcross, Rebecca K. Shears, Jagtur Singh Pooni, Jeremy Sizer, Benjamin Small, Richard Smith, Catherine Snelson, Tom Solomon, Rebecca G. Spencer, Nick Spittle, Shiranee Sriskandan, Nikki Staines, Tom Stambach, Richard Stewart, David Stuart, Krishanthi S. Subramaniam, Pradeep Subudhi, Olivia V. Swann, Tamas Szakmany, Agnieska Szemiel, Aislynn Taggart, Sarah Tait, Zoltan Takats, Panteleimon Takis, Jolanta Tanianis-Hughes, Kate Tatham, Richard S. Tedder, Jo Thomas, Jordan Thomas, Robert Thompson, Chris Thompson, Emma C. Thomson, Ascanio Tridente, Erwan Trochu, Darell Tupper-Carey, Lance C. W. Turtle, Mary Twagira, Nick Vallotton, Libby van Tonder, Rama Vancheeswaran, Rachel Vincent, Lisa Vincent-Smith, Shico Visuvanathan, Alan Vuylsteke, Sam Waddy, Rachel Wake, Andrew Walden, Ingeborg Welters, Murray Wham, Tony Whitehouse, Paul Whittaker, Ashley Whittington, Meme Wijesinghe, Eve Wilcock, Martin Williams, Lawrence Wilson, Stephen Winchester, Martin Wiselka, Adam Wolverson, Andrew Workman, Nicola Wrobel, Bryan Yates, Peter Young, Maria Zambon, J. Eunice Zhang
1w ago
Nature Immunology, Published online: 08 April 2024; doi:10.1038/s41590-024-01778-0 Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized ..read more
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TCF1–LEF1 co-expression identifies a multipotent progenitor cell (TH2-MPP) across human allergic diseases
Nature Immunology
by Radomir Kratchmarov, Sarah Djeddi, Garrett Dunlap, Wenqin He, Xiaojiong Jia, Caitlin M. Burk, Tessa Ryan, Alanna McGill, Jessica R. Allegretti, Raghu P. Kataru, Babak J. Mehrara, Erin M. Taylor, Shailesh Agarwal, Neil Bhattacharyya, Regan W. Bergmark, Alice Z. Maxfield, Stella Lee, Rachel Roditi, Daniel F. Dwyer, Joshua A. Boyce, Kathleen M. Buchheit, Tanya M. Laidlaw, Wayne G. Shreffler, Deepak A. Rao, Maria Gutierrez-Arcelus, Patrick J. Brennan
1w ago
Nature Immunology, Published online: 08 April 2024; doi:10.1038/s41590-024-01803-2 Kratchmarov et al. identified a GATA3+ TH2 population that expresses the transcription factors TCF1 and LEF1 and sustains type 2 inflammation in tissues over a human lifetime, despite chronic antigen exposure ..read more
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MEF2C regulates NK cell effector functions through control of lipid metabolism
Nature Immunology
by Joey H. Li, Adalia Zhou, Cassidy D. Lee, Siya N. Shah, Jeong Hyun Ji, Vignesh Senthilkumar, Eddie T. Padilla, Andréa B. Ball, Qinyan Feng, Christian G. Bustillos, Luke Riggan, Alain Greige, Ajit S. Divakaruni, Fran Annese, Jessica Cooley-Coleman, Steven A. Skinner, Christopher W. Cowan, Timothy E. O’Sullivan
1w ago
Nature Immunology, Published online: 08 April 2024; doi:10.1038/s41590-024-01811-2 Here the authors identify the transcription factor MEF2C as essential for human NK cell function and viral immunity in mice and humans. This control is exerted via regulation of lipid metabolism, and deficiency in MEF2C can be overcome by oleic acid supplementation ..read more
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Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity
Nature Immunology
by Megat H. B. A. Hamid, Pablo F. Cespedes, Chen Jin, Ji-Li Chen, Uzi Gileadi, Elie Antoun, Zhu Liang, Fei Gao, Renuka Teague, Nikita Manoharan, David Maldonado-Perez, Nasullah Khalid-Alham, Lucia Cerundolo, Raul Ciaoca, Svenja S. Hester, Adán Pinto-Fernández, Simeon D. Draganov, Iolanda Vendrell, Guihai Liu, Xuan Yao, Audun Kvalvaag, Delaney C. C. Dominey-Foy, Charunya Nanayakkara, Nikolaos Kanellakis, Yi-Ling Chen, Craig Waugh, Sally-Ann Clark, Kevin Clark, Paul Sopp, Najib M. Rahman, Clare Verrill, Benedikt M. Kessler, Graham Ogg, Ricardo A. Fernandes, Roman Fisher, Yanchun Peng, Michael L. Dustin, Tao Dong
2w ago
Nature Immunology, Published online: 01 April 2024; doi:10.1038/s41590-024-01802-3 CD103+ T cells are associated with control over tumors but how this is mediated is unclear. Here the authors show that CD61 colocalizes and functionally combines with CD103 in the T cell synaptic response to promote antitumor T cell responses ..read more
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Thioredoxin is a metabolic rheostat controlling regulatory B cells
Nature Immunology
by Hannah F. Bradford, Thomas C. R. McDonnell, Alexander Stewart, Andrew Skelton, Joseph Ng, Zara Baig, Franca Fraternali, Deborah Dunn-Walters, David A. Isenberg, Adnan R. Khan, Claudio Mauro, Claudia Mauri
2w ago
Nature Immunology, Published online: 29 March 2024; doi:10.1038/s41590-024-01798-w Here the authors show a mechanism by which mitochondrial electron transport and ROS contribute to the differentiation and function of regulatory B cells in the context of systemic lupus erythematosus ..read more
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Self-sustaining inflammatory cycle causes memory impairment in neuropsychiatric lupus
Nature Immunology
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2w ago
Nature Immunology, Published online: 22 March 2024; doi:10.1038/s41590-024-01786-0 Autoantibodies that develop in systemic lupus erythematosus (SLE) can cause long-term cognitive impairment that remains even after the systemic disease becomes quiescent. This study attributes the persistent cognitive symptoms of SLE to a self-sustaining neuroinflammatory process that continues indefinitely unless disrupted — which can be done using medications approved by the US Food and Drug Administration ..read more
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