CD63 sorts cholesterol into endosomes for storage and distribution via exosomes
Nature Cell Biology
by Roberta Palmulli, Mickaël Couty, Melissa C. Piontek, Maharajah Ponnaiah, Florent Dingli, Frederik J. Verweij, Stéphanie Charrin, Matteo Tantucci, Sajitha Sasidharan, Eric Rubinstein, Anatol Kontush, Damarys Loew, Marie Lhomme, Wouter H. Roos, Graça Raposo, Guillaume van Niel
2d ago
Nature Cell Biology, Published online: 17 June 2024; doi:10.1038/s41556-024-01432-9 Palmulli, Couty and colleagues show that the tetraspanin CD63 promotes accumulation of cholesterol in intraluminal vesicles (ILVs) at the expense of retrieval from endosomes; cholesterol stored in ILVs and exosomes is recovered in an NPC1-dependent manner ..read more
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Author Correction: RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis
Nature Cell Biology
by Zhentao Yang, Yan Wang, Yingying Zhang, Xiadi He, Chuan-Qi Zhong, Hengxiao Ni, Xin Chen, Yaoji Liang, Jianfeng Wu, Shimin Zhao, Dawang Zhou, Jiahuai Han
5d ago
Nature Cell Biology, Published online: 14 June 2024; doi:10.1038/s41556-024-01455-2 Author Correction: RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis ..read more
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Integrative analysis of ultra-deep RNA-seq reveals alternative promoter usage as a mechanism of activating oncogenic programmes during prostate cancer progression
Nature Cell Biology
by Meng Zhang, Martin Sjöström, Xiekui Cui, Adam Foye, Kyle Farh, Raunak Shrestha, Arian Lundberg, Ha X. Dang, Haolong Li, Phillip G. Febbo, Rahul Aggarwal, Joshi J. Alumkal, Eric J. Small, Felix Y. Feng, David A. Quigley, Christopher A. Maher
6d ago
Nature Cell Biology, Published online: 13 June 2024; doi:10.1038/s41556-024-01438-3 With ultra-deep RNA sequencing, Zhang et al. report increased usage of alternative promoters driven by AR, FOXA1 and MYC during prostate cancer progression and suggest altered DNA methylation as a potential underlying mechanism ..read more
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Three-dimensional chromatin reorganization regulates B cell development during ageing
Nature Cell Biology
by Fei Ma, Yaqiang Cao, Hansen Du, Fatima Zohra Braikia, Le Zong, Noah Ollikainen, Marc Bayer, Xiang Qiu, Bongsoo Park, Roshni Roy, Satabdi Nandi, Dimitra Sarantopoulou, Andrew Ziman, Aisha Haley Bianchi, Isabel Beerman, Keji Zhao, Rudolf Grosschedl, Ranjan Sen
6d ago
Nature Cell Biology, Published online: 12 June 2024; doi:10.1038/s41556-024-01424-9 Ma, Cao et al. uncover dynamic changes of chromatin reorganization in progenitor B cells during ageing, associated with altered H3K27ac levels and expression of genes that are critical for B cell development ..read more
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The glutathione S-transferase Gstt1 drives survival and dissemination in metastases
Nature Cell Biology
by Christina M. Ferrer, Hyo Min Cho, Ruben Boon, Tiziano Bernasocchi, Lai Ping Wong, Murat Cetinbas, Elizabeth R. Haggerty, Irene Mitsiades, Gregory R. Wojtkiewicz, Daniel E. McLoughlin, Reem Aboushousha, Hend Abdelhamid, Sita Kugel, Esther Rheinbay, Ruslan Sadreyev, Dejan Juric, Yvonne M. W. Janssen-Heininger, Raul Mostoslavsky
1w ago
Nature Cell Biology, Published online: 11 June 2024; doi:10.1038/s41556-024-01426-7 With a shRNA targeted screen, Ferrer, Cho, Boon et al. identify a role for Gstt1 in enhancing epithelial–mesenchymal transition and disseminated tumour cell features in a subset of slow-cycling cells, thereby facilitating metastatic progression ..read more
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Tumour microenvironment programming by an RNA–RNA-binding protein complex creates a druggable vulnerability in IDH-wild-type glioblastoma
Nature Cell Biology
by Lele Wu, Zheng Zhao, Yong Jae Shin, Yiyun Yin, Anandhkumar Raju, Thamil Selvan Vaiyapuri, Khaireen Idzham, Miseol Son, Yeri Lee, Jason K. Sa, Joelle Yi Heng Chua, Bilal Unal, You Zhai, Wenhua Fan, Lijie Huang, Huimin Hu, Jayantha Gunaratne, Do-Hyun Nam, Tao Jiang, Vinay Tergaonkar
1w ago
Nature Cell Biology, Published online: 10 June 2024; doi:10.1038/s41556-024-01428-5 Wu, Zhao, Shin and Yin show that the RNA–RNA-binding protein complex LOC–DHX15 drives microglia infiltration into the tumour microenvironment in glioblastoma and suggest targeting this complex as a potential treatment strategy ..read more
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Exploiting ferroptosis vulnerabilities in cancer
Nature Cell Biology
by Toshitaka Nakamura, Marcus Conrad
1w ago
Nature Cell Biology, Published online: 10 June 2024; doi:10.1038/s41556-024-01425-8 Ferroptosis is a form of cell death that is characterized by morphological abnormalities of mitochondria and the overwhelming peroxidation of phospholipids. Certain tumours are susceptible to ferroptosis, which could be exploited to treat cancers ..read more
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Extraembryonic gut endoderm cells undergo programmed cell death during development
Nature Cell Biology
by Julia Batki, Sara Hetzel, Dennis Schifferl, Adriano Bolondi, Maria Walther, Lars Wittler, Stefanie Grosswendt, Bernhard G. Herrmann, Alexander Meissner
1w ago
Nature Cell Biology, Published online: 07 June 2024; doi:10.1038/s41556-024-01431-w Batki, Hetzel et al. report a lineage-tracing strategy to track extraembryonic gut endoderm cells over development. They find that these cells are eventually eliminated in a p53-dependent manner and neighbouring embryonic cells clear their remnants ..read more
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Valine aminoacyl-tRNA synthetase promotes therapy resistance in melanoma
Nature Cell Biology
by Najla El-Hachem, Marine Leclercq, Miguel Susaeta Ruiz, Raphael Vanleyssem, Kateryna Shostak, Pierre-René Körner, Coralie Capron, Lorena Martin-Morales, Patrick Roncarati, Arnaud Lavergne, Arnaud Blomme, Silvia Turchetto, Eric Goffin, Palaniraja Thandapani, Ivan Tarassov, Laurent Nguyen, Bernard Pirotte, Alain Chariot, Jean-Christophe Marine, Michael Herfs, Francesca Rapino, Reuven Agami, Pierre Close
1w ago
Nature Cell Biology, Published online: 07 June 2024; doi:10.1038/s41556-024-01439-2 El-Hachem et al. show that MAPK therapy upregulates valine aminoacyl-tRNA synthetase and alters fatty acid oxidation by promoting translation of valine-enriched transcripts, providing a resistance mechanism that may be therapeutically targeted ..read more
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Translational control by VARS in melanoma
Nature Cell Biology
by Qiushuang Wu, Sohail F. Tavazoie
1w ago
Nature Cell Biology, Published online: 07 June 2024; doi:10.1038/s41556-024-01430-x Aminoacyl-tRNA synthetases can promote or suppress cancer progression by regulating codon-dependent translation. A study now shows that valine aminoacyl-tRNA synthetase (VARS) promotes therapeutic resistance of melanoma to MAPK pathway inhibitors by enhancing translation of valine-enriched genes, including the fatty acid oxidation gene HADH ..read more
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