Nature Cell Biology, Published online: 26 April 2024; doi:10.1038/s41556-024-01405-y LPCAT1-mediated membrane phospholipid remodelling promotes ferroptosis evasion and tumour growth ..read more

Nature Cell Biology, Published online: 23 April 2024; doi:10.1038/s41556-024-01406-x We show that the mitochondrial fission proteins MiD49 and MiD51 are activated by fatty acyl-coenzyme A (FA-CoA). FA-CoA binds in a previously identified pocket located within MiDs, inducing their oligomerization and ability to activate the dynamin DRP1, ultimately promoting mitochondrial fission. Activated MiDs synergize with mitochondrial fission factor (MFF) in stimulating DRP1 activity, leading us to hypothesize that MiDs act upstream of MFF during mitochondrial fission ..read more

Nature Cell Biology, Published online: 19 April 2024; doi:10.1038/s41556-024-01407-w Reicher, Reiniš et al. report a method for multicolour tagging using genome-scale intron-targeting sgRNA libraries that, in combination with computer vision, enables the systematic detection of protein localization changes ..read more

Nature Cell Biology, Published online: 19 April 2024; doi:10.1038/s41556-024-01404-z Our understanding of the basic mechanisms of autophagy is growing, but many questions remain about the types of autophagy cells use, when they use them, and how they function in different contexts. We asked emerging and established leaders in the field to discuss the questions and areas that they are most excited about to deepen our understanding of autophagy ..read more

Nature Cell Biology, Published online: 12 April 2024; doi:10.1038/s41556-024-01381-3 Volume electron microscopy (vEM) generates large 3D volumes of cells or tissues at nanoscale resolutions, enabling analyses of organelles in their cellular environment. Here, we provide examples of vEM in cell biology and discuss community efforts to develop standards in sample preparation and image acquisition for enhanced reproducibility and data reuse ..read more

Nature Cell Biology, Published online: 11 April 2024; doi:10.1038/s41556-024-01402-1 Chidley et al. report a CRISPR interference/activation screening platform to systematically interrogate the contribution of nutrient transporters to support cancer cell proliferation in environments of variable composition ..read more

Nature Cell Biology, Published online: 10 April 2024; doi:10.1038/s41556-024-01391-1 Three studies identify a transcription-coupled DNA–protein cross-link repair pathway that depends on the Cockayne syndrome proteins and the proteasome ..read more

Nature Cell Biology, Published online: 10 April 2024; doi:10.1038/s41556-024-01401-2 Three studies identify a transcription-coupled DNA–protein crosslink repair pathway that depends on the Cockayne syndrome proteins and the proteasome ..read more

Nature Cell Biology, Published online: 10 April 2024; doi:10.1038/s41556-024-01394-y Three studies identify a transcription-coupled DNA–protein crosslink repair pathway that depends on the Cockayne syndrome proteins and the proteasome ..read more

Nature Cell Biology, Published online: 10 April 2024; doi:10.1038/s41556-024-01392-0 Organ morphogenesis begins with proliferation, which results in tissue pressures and site-specific YAP expression, nuclear translocation and signalling. A study now reports the involvement of anisotropy, localized pressure and YAP signalling in organizer-forming cascades, introducing a new chapter of molecular mechanobiology of organogenesis ..read more