Nature Cell Biology, Published online: 24 July 2024; doi:10.1038/s41556-024-01471-2 Publisher Correction: A dual role of ERGIC-localized Rabs in TMED10-mediated unconventional protein secretion ..read more

Nature Cell Biology, Published online: 22 July 2024; doi:10.1038/s41556-024-01462-3 Shi, Zhou, Xuan, Jiang et al. identify a population of CD8+ T cells that migrate from bone marrow to the small intestine during leukaemogenesis and then traffic back to contribute to anti-leukaemia immune responses during chemotherapy treatment ..read more

Nature Cell Biology, Published online: 19 July 2024; doi:10.1038/s41556-024-01466-z Mutations in the gene encoding the E3 ubiquitin ligase TRIAD3A cause adult-onset neurodegenerative disorders. We reveal that the ubiquitin ligase activity of TRIAD3A promotes its liquid–liquid phase separation. TRIAD3A co-partitions with tau into droplets, where tau forms fibrillar aggregates. TRIAD3A mediates the degradation of these aggregates through its role as an autophagy adaptor ..read more

Nature Cell Biology, Published online: 18 July 2024; doi:10.1038/s41556-024-01460-5 Werbowetski-Ogilvie, Taylor and colleagues report a noncanonical role for OTX2 in regulating alternative splicing and controlling a stem cell and pro-tumorigenic splicing program in group 3 medulloblastoma ..read more

Nature Cell Biology, Published online: 15 July 2024; doi:10.1038/s41556-024-01464-1 Schwab, Rao et al. report that Zeb1 mediates enhanced ferroptosis sensitivity in cancer cells after EMT activation, associated with altered expression of selected lipogenic enzymes and an subsequent increase in the PUFA:MUFA ratio ..read more

Nature Cell Biology, Published online: 15 July 2024; doi:10.1038/s41556-024-01461-4 Zhou et al. show that the E3 ubiquitin ligase TRIAD3A assembles into liquid–liquid phase-separated droplets that contain tau and promote conversion to fibrillar aggregates and tau autophagic degradation ..read more

Nature Cell Biology, Published online: 12 July 2024; doi:10.1038/s41556-024-01440-9 Jiang et al. document an abundance of neutrophil-derived migrasomes in the blood of mice and humans and show that migrasomes are enriched in coagulation factors, accumulate at sites of injury and trigger platelet activation and clot formation ..read more

Nature Cell Biology, Published online: 12 July 2024; doi:10.1038/s41556-024-01459-y Cai et al. show that, in lysosomes under hydrostatic pressure in macrophages, lysosomal mechanosensitive channels cause a cation leak. This leads to the inhibition of mTORC1, activation of TFEB/TFE3 and release of monocyte chemoattractant proteins ..read more

Nature Cell Biology, Published online: 08 July 2024; doi:10.1038/s41556-024-01435-6 In two independent studies, Sun, Liu et al. and Sun et al. develop SPATAC-seq to map the chromatin accessibility landscape of zebrafish embryogenesis and mouse organogenesis, respectively, and identify transcription regulators that determine cell fate ..read more

Nature Cell Biology, Published online: 08 July 2024; doi:10.1038/s41556-024-01449-0 In two independent studies, Sun, Liu et al. and Sun et al. develop SPATAC-seq to map the chromatin accessibility landscape of zebrafish embryogenesis and mouse organogenesis, respectively, and identify transcription regulators that determine cell fate ..read more