Lipid droplet-associated lncRNA LIPTER preserves cardiac lipid metabolism
Nature Cell Biology
by Lei Han, Dayang Huang, Shiyong Wu, Sheng Liu, Cheng Wang, Yi Sheng, Xiongbin Lu, Hal E. Broxmeyer, Jun Wan, Lei Yang
4d ago
Nature Cell Biology, Published online: 01 June 2023; doi:10.1038/s41556-023-01162-4 Han et al. identify the long non-coding RNA LIPTER as a key mediator of lipid droplet transport and metabolism in human cardiomyocytes. LIPTER overexpression mitigates cardiomyopathy and preserves cardiac function in obese and diabetic mouse models ..read more
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A people-centric approach to pursuing scientific discovery
Nature Cell Biology
by Melina Casadio
4d ago
Nature Cell Biology, Published online: 30 May 2023; doi:10.1038/s41556-023-01151-7 Chun-Yan Lim is a group leader at the Guangzhou Laboratory, China, studying organelle contacts as metabolic signaling hubs. We reached out to Chun-Yan to discuss his scientific career and life in the lab ..read more
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Publisher Correction: Arg-tRNA synthetase links inflammatory metabolism to RNA splicing and nuclear trafficking via SRRM2
Nature Cell Biology
by Haissi Cui, Jolene K. Diedrich, Douglas C. Wu, Justin J. Lim, Ryan M. Nottingham, James J. Moresco, John R. Yates III, Benjamin J. Blencowe, Alan M. Lambowitz, Paul Schimmel
4d ago
Nature Cell Biology, Published online: 26 May 2023; doi:10.1038/s41556-023-01172-2 Publisher Correction: Arg-tRNA synthetase links inflammatory metabolism to RNA splicing and nuclear trafficking via SRRM2 ..read more
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Divergent metabolic programmes control two populations of MAIT cells that protect the lung
Nature Cell Biology
by Thomas Riffelmacher, Mallory Paynich Murray, Chantal Wientjens, Shilpi Chandra, Viankail Cedillo-Castelán, Ting-Fang Chou, Sara McArdle, Christopher Dillingham, Jordan Devereaux, Aaron Nilsen, Simon Brunel, David M. Lewinsohn, Jeff Hasty, Gregory Seumois, Christopher A. Benedict, Pandurangan Vijayanand, Mitchell Kronenberg
4d ago
Nature Cell Biology, Published online: 25 May 2023; doi:10.1038/s41556-023-01152-6 Riffelmacher et al. show that immunization with a live vaccine strain leads to the expansion of two memory-like mucosal-associated invariant T cell lineages with distinct metabolic needs, effector programmes and protective capacities ..read more
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Autophagy enables microglia to engage amyloid plaques and prevents microglial senescence
Nature Cell Biology
by Insup Choi, Minghui Wang, Seungyeul Yoo, Peng Xu, Steven P. Seegobin, Xianting Li, Xian Han, Qian Wang, Junmin Peng, Bin Zhang, Zhenyu Yue
4d ago
Nature Cell Biology, Published online: 25 May 2023; doi:10.1038/s41556-023-01158-0 Choi et al. show that autophagy is activated in disease-associated microglia in Alzheimer’s disease mouse models, which prevents microglial senescence entry. Blocking microglial autophagy aggravates neuropathology in Alzheimer’s disease mice ..read more
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Host protection by two memory-like MAIT subsets
Nature Cell Biology
by Margarita Dominguez-Villar
4d ago
Nature Cell Biology, Published online: 25 May 2023; doi:10.1038/s41556-023-01149-1 How mucosal-associated invariant T (MAIT) cells acquire memory-like features after infection and the factors that control this process have been unclear. A study now defines two subsets of antigen-adapted MAIT cells emerging after immunization that differ in functions, lung localization and metabolic requirements ..read more
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Mitoprotease LONP1 controls white-to-beige adipocyte conversion via metabolic enzyme turnover
Nature Cell Biology
by
2w ago
Nature Cell Biology, Published online: 24 May 2023; doi:10.1038/s41556-023-01161-5 This study reveals that thermogenic stimuli activate mitochondrial proteolysis via LONP1 to sustain the succinate levels required for efficient conversion of white adipocytes to beige adipocytes. Our work highlights mitochondrial proteases (mitoproteases) as a link between environmental stimuli, metabolite levels and cell identity switching ..read more
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B cell senescence takes guts
Nature Cell Biology
by Bennett G. Childs, Sara I. Graves, Darren J. Baker
2w ago
Nature Cell Biology, Published online: 24 May 2023; doi:10.1038/s41556-023-01153-5 Accumulation of senescent cells and compositional changes in gut microbiota have been independently reported to occur as a function of age. A study now suggests that these two seemingly disparate processes are more intimately linked than previously appreciated via a B cell–IgA–microbiota axis ..read more
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Proteolytic rewiring of mitochondria by LONP1 directs cell identity switching of adipocytes
Nature Cell Biology
by Tingting Fu, Wanping Sun, Jiachen Xue, Zheng Zhou, Wen Wang, Qiqi Guo, Xinyi Chen, Danxia Zhou, Zhisheng Xu, Lin Liu, Liwei Xiao, Yan Mao, Likun Yang, Yujing Yin, Xue-Na Zhang, Qiangyou Wan, Bin Lu, Yuncong Chen, Min-Sheng Zhu, Philipp E. Scherer, Lei Fang, Hai-Long Piao, Mengle Shao, Zhenji Gan
2w ago
Nature Cell Biology, Published online: 22 May 2023; doi:10.1038/s41556-023-01155-3 Fu, Sun, Xue, Zhou et al. show that the mitoprotease LONP1 selectively degrades a complex II component to control intracellular succinate levels, which is needed for white-to-beige adipocyte cell fate programming during adipocyte thermogenic remodelling ..read more
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Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification
Nature Cell Biology
by Punn Augsornworawat, Nathaniel J. Hogrebe, Matthew Ishahak, Mason D. Schmidt, Erica Marquez, Marlie M. Maestas, Daniel A. Veronese-Paniagua, Sarah E. Gale, Julia R. Miller, Leonardo Velazco-Cruz, Jeffrey R. Millman
3w ago
Nature Cell Biology, Published online: 15 May 2023; doi:10.1038/s41556-023-01150-8 Augsornworawat et al. perform single-nucleus multi-omics and integrated transcriptional and chromatin analysis to identify differences between human stem cell-derived and primary islets ..read more
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