Nature Cell Biology, Published online: 01 June 2023; doi:10.1038/s41556-023-01162-4 Han et al. identify the long non-coding RNA LIPTER as a key mediator of lipid droplet transport and metabolism in human cardiomyocytes. LIPTER overexpression mitigates cardiomyopathy and preserves cardiac function in obese and diabetic mouse models ..read more

Nature Cell Biology, Published online: 30 May 2023; doi:10.1038/s41556-023-01151-7 Chun-Yan Lim is a group leader at the Guangzhou Laboratory, China, studying organelle contacts as metabolic signaling hubs. We reached out to Chun-Yan to discuss his scientific career and life in the lab ..read more

Nature Cell Biology, Published online: 26 May 2023; doi:10.1038/s41556-023-01172-2 Publisher Correction: Arg-tRNA synthetase links inflammatory metabolism to RNA splicing and nuclear trafficking via SRRM2 ..read more

Nature Cell Biology, Published online: 25 May 2023; doi:10.1038/s41556-023-01152-6 Riffelmacher et al. show that immunization with a live vaccine strain leads to the expansion of two memory-like mucosal-associated invariant T cell lineages with distinct metabolic needs, effector programmes and protective capacities ..read more

Nature Cell Biology, Published online: 25 May 2023; doi:10.1038/s41556-023-01158-0 Choi et al. show that autophagy is activated in disease-associated microglia in Alzheimer’s disease mouse models, which prevents microglial senescence entry. Blocking microglial autophagy aggravates neuropathology in Alzheimer’s disease mice ..read more

Nature Cell Biology, Published online: 25 May 2023; doi:10.1038/s41556-023-01149-1 How mucosal-associated invariant T (MAIT) cells acquire memory-like features after infection and the factors that control this process have been unclear. A study now defines two subsets of antigen-adapted MAIT cells emerging after immunization that differ in functions, lung localization and metabolic requirements ..read more

Nature Cell Biology, Published online: 24 May 2023; doi:10.1038/s41556-023-01161-5 This study reveals that thermogenic stimuli activate mitochondrial proteolysis via LONP1 to sustain the succinate levels required for efficient conversion of white adipocytes to beige adipocytes. Our work highlights mitochondrial proteases (mitoproteases) as a link between environmental stimuli, metabolite levels and cell identity switching ..read more

Nature Cell Biology, Published online: 24 May 2023; doi:10.1038/s41556-023-01153-5 Accumulation of senescent cells and compositional changes in gut microbiota have been independently reported to occur as a function of age. A study now suggests that these two seemingly disparate processes are more intimately linked than previously appreciated via a B cell–IgA–microbiota axis ..read more

Nature Cell Biology, Published online: 22 May 2023; doi:10.1038/s41556-023-01155-3 Fu, Sun, Xue, Zhou et al. show that the mitoprotease LONP1 selectively degrades a complex II component to control intracellular succinate levels, which is needed for white-to-beige adipocyte cell fate programming during adipocyte thermogenic remodelling ..read more

Nature Cell Biology, Published online: 15 May 2023; doi:10.1038/s41556-023-01150-8 Augsornworawat et al. perform single-nucleus multi-omics and integrated transcriptional and chromatin analysis to identify differences between human stem cell-derived and primary islets ..read more