Spermidine mediates acetylhypusination of RIPK1 to suppress diabetes onset and progression
Nature Cell Biology
by Tian Zhang, Weixin Fu, Haosong Zhang, Jianlong Li, Beizi Xing, Yuping Cai, Mengmeng Zhang, Xuheng Liu, Chunting Qi, Lihui Qian, Xinbo Hu, Hua Zhu, Shuailong Yang, Min Zhang, Jianping Liu, Ganquan Li, Yang Li, Rong Xiang, Zhengqiang Qi, Junhao Hu, Ying Li, Chengyu Zou, Qin Wang, Xia Jin, Rui Pang, Peiying Li, Junli Liu, Yaoyang Zhang, Zhaoyin Wang, Zheng-Jiang Zhu, Bing Shan, Junying Yuan
4d ago
Nature Cell Biology, Published online: 07 November 2024; doi:10.1038/s41556-024-01540-6 Zhang et al. show that the activation of RIPK1 is suppressed by acetylhypusination in a spermidine-dependent manner. Disruption of this axis contributes to RIPK1-mediated vascular pathology to promote insulin resistance and diabetic kidney pathology ..read more
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Spermidine limits diabetes by modulating RIPK1-mediated cell death and inflammation
Nature Cell Biology
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4d ago
Nature Cell Biology, Published online: 07 November 2024; doi:10.1038/s41556-024-01542-4 We establish a mouse model of progressive diabetes induced by conditional NAT1 deficiency in vascular endothelial cells. NAT1 deficiency promotes the activation of RIPK1 owing to a type of post-translational modification mediated by spermidine and deoxyhyupisin synthase termed acetyl-hypusination. Our results suggest that inhibition of RIPK1 could be used to treat type 2 diabetes and vascular inflammation ..read more
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NAT10-mediated mRNA N4-acetylcytidine reprograms serine metabolism to drive leukaemogenesis and stemness in acute myeloid leukaemia
Nature Cell Biology
by Subo Zhang, Feng Huang, Yushuai Wang, Yifei Long, Yuanpei Li, Yalin Kang, Weiwei Gao, Xiuxin Zhang, Yueting Wen, Yun Wang, Lili Pan, Youmei Xia, Zhoutian Yang, Ying Yang, Hongjie Mo, Baiqing Li, Jiacheng Hu, Yunda Song, Shilin Zhang, Shenghua Dong, Xiao Du, Yingmin Li, Yadi Liu, Wenting Liao, Yijun Gao, Yaojun Zhang, Hongming Chen, Yang Liang, Jianjun Chen, Hengyou Weng, Huilin Huang
5d ago
Nature Cell Biology, Published online: 06 November 2024; doi:10.1038/s41556-024-01548-y Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia ..read more
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Spatiotemporal coordination of actin regulators generates invasive protrusions in cell–cell fusion
Nature Cell Biology
by Yue Lu, Tezin Walji, Benjamin Ravaux, Pratima Pandey, Changsong Yang, Bing Li, Delgermaa Luvsanjav, Kevin H. Lam, Ruihui Zhang, Zhou Luo, Chuanli Zhou, Christa W. Habela, Scott B. Snapper, Rong Li, David J. Goldhamer, David W. Schmidtke, Duojia Pan, Tatyana M. Svitkina, Elizabeth H. Chen
1w ago
Nature Cell Biology, Published online: 01 November 2024; doi:10.1038/s41556-024-01541-5 Lu et al. reveal the spatiotemporal coordination between two nucleation-promoting factors, WAVE and N-WASP, and two actin-bundling proteins, dynamin and WIP, in generating invasive protrusions at the mammalian myoblast fusogenic synapse ..read more
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Caspase-2 is a condensate-mediated deubiquitinase in protein quality control
Nature Cell Biology
by Yingwei Ge, Lijie Zhou, Yesheng Fu, Lijuan He, Yi Chen, Dingchang Li, Yuping Xie, Jun Yang, Haitao Wu, Hongmiao Dai, Zhiqiang Peng, Yong Zhang, Shaoqiong Yi, Bo Wu, Xin Zhang, Yangjun Zhang, Wantao Ying, Chun-Ping Cui, Cui Hua Liu, Lingqiang Zhang
1w ago
Nature Cell Biology, Published online: 31 October 2024; doi:10.1038/s41556-024-01522-8 Ge, Zhou, Fu et al. find caspase-2 accumulates in biomolecular condensates with ubiquitin and proteasomal components and functions as a deubiquitinase following stress. Caspase-2-deficient mice accumulate poly-ubiquitinated TDP-43 and show motor defects ..read more
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H3K27 dimethylation dynamics reveal stepwise establishment of facultative heterochromatin in early mouse embryos
Nature Cell Biology
by Masahiro Matsuwaka, Mami Kumon, Azusa Inoue
1w ago
Nature Cell Biology, Published online: 31 October 2024; doi:10.1038/s41556-024-01553-1 Matsuwaka et al. show that JARID2-PRC2 initiates H3K27me2 deposition during the eight-cell-to-morula transition, following H2AK119 mono-ubiquitylation deposition. It is also required for the subsequent H3K27me3 deposition at the blastocyst stage ..read more
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Cohesin complex oligomerization maintains end-tethering at DNA double-strand breaks
Nature Cell Biology
by Jamie Phipps, Mathias Toulouze, Cécile Ducrot, Rafaël Costa, Clémentine Brocas, Karine Dubrana
1w ago
Nature Cell Biology, Published online: 31 October 2024; doi:10.1038/s41556-024-01552-2 Phipps et al. report a cohesin-dependent double-strand break (DSB) DNA end-tethering mechanism that requires Exo1 and SMC5/6 in budding yeast. They show that cohesin oligomerization promotes DSB end-tethering and repair, safeguarding genomic integrity ..read more
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Distinct H3K9me3 heterochromatin maintenance dynamics govern different gene programmes and repeats in pluripotent cells
Nature Cell Biology
by Jingchao Zhang, Greg Donahue, Michael B. Gilbert, Tomer Lapidot, Dario Nicetto, Kenneth S. Zaret
1w ago
Nature Cell Biology, Published online: 31 October 2024; doi:10.1038/s41556-024-01547-z Zhang et al. uncover different dynamics underlying the maintenance and regulation of H3K9me3-enriched heterochromatin domains in mouse embryonic stem cells and propose that loss of H3K9me3 occurs through two distinct dynamic modes: passive dilution and active removal ..read more
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Temporal dynamics of membrane contact sites
Nature Cell Biology
by Tomas Knedlik, Marta Giacomello
1w ago
Nature Cell Biology, Published online: 31 October 2024; doi:10.1038/s41556-024-01539-z Cell behaviour changes temporally in response to environmental and metabolic cues. This also applies to membrane contact sites (MCSs), where organelles come into close proximity to perform specific functions, such as lipid transfer or calcium signalling. Here, we discuss how MCSs change over time and whether MCSs exhibit circadian rhythmicity ..read more
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Building the epigenetic fortress with PRC2.2
Nature Cell Biology
by Fides Zenk
1w ago
Nature Cell Biology, Published online: 31 October 2024; doi:10.1038/s41556-024-01551-3 How heterochromatin is established de novo in early embryos is unknown. A study now shows that the sequential recruitment of the key regulator JARID2 recruits PRC2.2 to H2AK119ub and ensures proper H3K27me2/3 deposition. This prevents premature enhancer activation, which is crucial for gene regulation and lineage specification ..read more
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