Nature Cell Biology
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Nature Cell Biology publishes research of the highest quality across all areas of cell biology, encouraging studies that shed light on the mechanisms underlying fundamental cell biological processes in physiology and disease.
Nature Cell Biology
4d ago
Nature Cell Biology, Published online: 07 November 2024; doi:10.1038/s41556-024-01540-6
Zhang et al. show that the activation of RIPK1 is suppressed by acetylhypusination in a spermidine-dependent manner. Disruption of this axis contributes to RIPK1-mediated vascular pathology to promote insulin resistance and diabetic kidney pathology ..read more
Nature Cell Biology
4d ago
Nature Cell Biology, Published online: 07 November 2024; doi:10.1038/s41556-024-01542-4
We establish a mouse model of progressive diabetes induced by conditional NAT1 deficiency in vascular endothelial cells. NAT1 deficiency promotes the activation of RIPK1 owing to a type of post-translational modification mediated by spermidine and deoxyhyupisin synthase termed acetyl-hypusination. Our results suggest that inhibition of RIPK1 could be used to treat type 2 diabetes and vascular inflammation ..read more
Nature Cell Biology
5d ago
Nature Cell Biology, Published online: 06 November 2024; doi:10.1038/s41556-024-01548-y
Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia ..read more
Nature Cell Biology
1w ago
Nature Cell Biology, Published online: 01 November 2024; doi:10.1038/s41556-024-01541-5
Lu et al. reveal the spatiotemporal coordination between two nucleation-promoting factors, WAVE and N-WASP, and two actin-bundling proteins, dynamin and WIP, in generating invasive protrusions at the mammalian myoblast fusogenic synapse ..read more
Nature Cell Biology
1w ago
Nature Cell Biology, Published online: 31 October 2024; doi:10.1038/s41556-024-01522-8
Ge, Zhou, Fu et al. find caspase-2 accumulates in biomolecular condensates with ubiquitin and proteasomal components and functions as a deubiquitinase following stress. Caspase-2-deficient mice accumulate poly-ubiquitinated TDP-43 and show motor defects ..read more
Nature Cell Biology
1w ago
Nature Cell Biology, Published online: 31 October 2024; doi:10.1038/s41556-024-01553-1
Matsuwaka et al. show that JARID2-PRC2 initiates H3K27me2 deposition during the eight-cell-to-morula transition, following H2AK119 mono-ubiquitylation deposition. It is also required for the subsequent H3K27me3 deposition at the blastocyst stage ..read more
Nature Cell Biology
1w ago
Nature Cell Biology, Published online: 31 October 2024; doi:10.1038/s41556-024-01552-2
Phipps et al. report a cohesin-dependent double-strand break (DSB) DNA end-tethering mechanism that requires Exo1 and SMC5/6 in budding yeast. They show that cohesin oligomerization promotes DSB end-tethering and repair, safeguarding genomic integrity ..read more
Nature Cell Biology
1w ago
Nature Cell Biology, Published online: 31 October 2024; doi:10.1038/s41556-024-01547-z
Zhang et al. uncover different dynamics underlying the maintenance and regulation of H3K9me3-enriched heterochromatin domains in mouse embryonic stem cells and propose that loss of H3K9me3 occurs through two distinct dynamic modes: passive dilution and active removal ..read more
Nature Cell Biology
1w ago
Nature Cell Biology, Published online: 31 October 2024; doi:10.1038/s41556-024-01539-z
Cell behaviour changes temporally in response to environmental and metabolic cues. This also applies to membrane contact sites (MCSs), where organelles come into close proximity to perform specific functions, such as lipid transfer or calcium signalling. Here, we discuss how MCSs change over time and whether MCSs exhibit circadian rhythmicity ..read more
Nature Cell Biology
1w ago
Nature Cell Biology, Published online: 31 October 2024; doi:10.1038/s41556-024-01551-3
How heterochromatin is established de novo in early embryos is unknown. A study now shows that the sequential recruitment of the key regulator JARID2 recruits PRC2.2 to H2AK119ub and ensures proper H3K27me2/3 deposition. This prevents premature enhancer activation, which is crucial for gene regulation and lineage specification ..read more