Branched chemically modified poly(A) tails enhance the translation capacity of mRNA
Nature » Biotechnology
by Hongyu Chen, Dangliang Liu, Jianting Guo, Abhishek Aditham, Yiming Zhou, Jiakun Tian, Shuchen Luo, Jingyi Ren, Alvin Hsu, Jiahao Huang, Franklin Kostas, Mingrui Wu, David R. Liu, Xiao Wang
6d ago
Nature Biotechnology, Published online: 22 March 2024; doi:10.1038/s41587-024-02174-7 mRNA with engineered poly(A) tails produces prolonged higher levels of protein ..read more
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De novo and somatic structural variant discovery with SVision-pro
Nature » Biotechnology
by Songbo Wang, Jiadong Lin, Peng Jia, Tun Xu, Xiujuan Li, Yuezhuangnan Liu, Dan Xu, Stephen J. Bush, Deyu Meng, Kai Ye
6d ago
Nature Biotechnology, Published online: 22 March 2024; doi:10.1038/s41587-024-02190-7 SVision-pro enables pairwise genome comparison and improves de novo and somatic structural variant calling ..read more
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Starfysh integrates spatial transcriptomic and histologic data to reveal heterogeneous tumor–immune hubs
Nature » Biotechnology
by Siyu He, Yinuo Jin, Achille Nazaret, Lingting Shi, Xueer Chen, Sham Rampersaud, Bahawar S. Dhillon, Izabella Valdez, Lauren E. Friend, Joy Linyue Fan, Cameron Y. Park, Rachel L. Mintz, Yeh-Hsing Lao, David Carrera, Kaylee W. Fang, Kaleem Mehdi, Madeline Rohde, José L. McFaline-Figueroa, David Blei, Kam W. Leong, Alexander Y. Rudensky, George Plitas, Elham Azizi
6d ago
Nature Biotechnology, Published online: 21 March 2024; doi:10.1038/s41587-024-02173-8 Reference-free integrative analysis of spatial transcriptomics data is achieved with archetype analysis ..read more
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Making genome editing a success story in Africa
Nature » Biotechnology
by Hussein M. Abkallo, Patrick Arbuthnot, Thomas O. Auer, Dave K. Berger, Johan Burger, Ereck Chakauya, Jean-Paul Concordet, Abdoulaye Diabate, Vincenzo Di Donato, Jan-Hendrik Groenewald, Amadou Guindo, Lizette L. Koekemoer, Florence Nazare, Tony Nolan, Fredros Okumu, Emma Orefuwa, Lily Paemka, Lucia Prieto-Godino, Steven Runo, Marie Sadler, Kassahun Tesfaye, Leena Tripathi, Charles Wondji
1w ago
Nature Biotechnology, Published online: 19 March 2024; doi:10.1038/s41587-024-02187-2 Making genome editing a success story in Africa ..read more
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A retrotransposon for site-specific gene transfer
Nature » Biotechnology
by Fred Dyda, Alison B. Hickman
1w ago
Nature Biotechnology, Published online: 18 March 2024; doi:10.1038/s41587-024-02180-9 An engineered retrotransposon achieves targeted gene transfer into the human genome ..read more
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Cell-based coffee future-proofs world’s favorite brew
Nature » Biotechnology
by Claire Turrell
1w ago
Nature Biotechnology, Published online: 15 March 2024; doi:10.1038/s41587-024-02181-8 Cell-based coffee future-proofs world’s favorite brew ..read more
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World’s first TIL therapy approved
Nature » Biotechnology
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1w ago
Nature Biotechnology, Published online: 15 March 2024; doi:10.1038/s41587-024-02195-2 World’s first TIL therapy approved ..read more
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Predicting the structure of large protein complexes
Nature » Biotechnology
by Iris Marchal
1w ago
Nature Biotechnology, Published online: 15 March 2024; doi:10.1038/s41587-024-02183-6 Predicting the structure of large protein complexes ..read more
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In vivo CRISPR agent cuts HAE attacks 95%
Nature » Biotechnology
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1w ago
Nature Biotechnology, Published online: 15 March 2024; doi:10.1038/s41587-024-02188-1 In vivo CRISPR agent cuts HAE attacks 95 ..read more
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A synthetic antibiotic overcomes antimicrobial resistance
Nature » Biotechnology
by Iris Marchal
1w ago
Nature Biotechnology, Published online: 15 March 2024; doi:10.1038/s41587-024-02185-4 A synthetic antibiotic overcomes antimicrobial resistance ..read more
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