Sports Med. 2024 May 6. doi: 10.1007/s40279-024-02016-1. Online ahead of print. ABSTRACT BACKGROUND: The interplay of physical activity (PA) with affective well-being (AWB) is highly critical to both health behaviors and health outcomes. Current prominent theories presume AWB to be crucial for PA maintenance, and PA is evidenced to foster mental health. However, thus far, PA-AWB associations have mainly been researched in laboratory settings and with interventional designs, but the everyday life perspective had not been focused on, mostly due to technological limitations. In the course of dig ..read more

BMC Womens Health. 2024 May 5;24(1):275. doi: 10.1186/s12905-024-03079-y. ABSTRACT BACKGROUND: In this study we shed light on ongoing trends in contraceptive use in Flanders (Belgium). Building on the fundamental cause theory and social diffusion of innovation theory, we examine socio-economic gradients in contraceptive use and the relationship to health behaviours. METHODS: Using the unique and recently collected (2020) ISALA data, we used multinomial logistic regression to model the uptake of contraceptives and its association to educational level and health behaviour (N:4316 women). RESULT ..read more

BMC Cardiovasc Disord. 2024 May 5;24(1):237. doi: 10.1186/s12872-024-03908-w. ABSTRACT Some individuals who go to fitness centers for various purposes perform resistance exercise (RE) alone, while others engage in combined exercise (CE) by including cardio exercises along with RE. Studying the effects of these two different training methods on left ventricular (LV) systolic and diastolic parameters and left atrial mechanical function is an important step toward understanding the effects of different types of exercise on cardiac function. This knowledge has significant implications for public ..read more

Zhonghua Yi Xue Za Zhi. 2024 May 7;104(17):1453-1455. doi: 10.3760/cma.j.cn112137-20230928-00611. ABSTRACT The implementation of death determination by clinicians usually involves three steps: learning the concept of death, mastering the skills of death determination, and recording the results of death determination. Each process needs to be changed with the progress of medical science. The transformation of brain death concept is the establishment and formation of the latest cognition of “irreversible brain function”, which needs to be completed based on the theoretical learning of recognize ..read more

Acta Neuropathol Commun. 2024 May 5;12(1):71. doi: 10.1186/s40478-024-01765-4. ABSTRACT Diffuse Intrinsic Pontine Glioma (DIPG) is a highly aggressive and fatal pediatric brain cancer. One pre-requisite for tumor cells to infiltrate is adhesion to extracellular matrix (ECM) components. However, it remains largely unknown which ECM proteins are critical in enabling DIPG adhesion and migration and which integrin receptors mediate these processes. Here, we identify laminin as a key ECM protein that supports robust DIPG cell adhesion and migration. To study DIPG infiltration, we developed a DIPG ..read more

J AAPOS. 2024 May 3:103929. doi: 10.1016/j.jaapos.2024.103929. Online ahead of print. ABSTRACT PURPOSE: To investigate the incidence of psychiatric diagnoses in relation to strabismus surgery timing among children with an early strabismus diagnosis who underwent surgery in childhood. METHODS: We conducted a retrospective cohort study using TriNetX network data from 2003-2023 on patients diagnosed with strabismus at ≤5 years of age and having strabismus surgery before 18 years of age. Cohort 1 comprised patients who underwent initial strabismus surgery at ≤6 years of age; cohort 2, patients wi ..read more

Trends Genet. 2024 May 4:S0168-9525(24)00078-7. doi: 10.1016/j.tig.2024.04.004. Online ahead of print. ABSTRACT Due to their capacity to mediate repetitive protein interactions, intrinsically disordered regions (IDRs) are crucial for the formation of various types of protein-RNA complexes. The functions of IDRs are strongly modulated by post-translational modifications (PTMs). Phosphorylation is the most common and well-studied modification of IDRs, which can alter homomeric or heteromeric interactions of proteins and impact their ability to phase separate. Moreover, phosphorylation can influ ..read more

J Am Pharm Assoc (2003). 2024 May 3:102113. doi: 10.1016/j.japh.2024.102113. Online ahead of print. ABSTRACT BACKGROUND: Tricyclic antidepressants (TCAs) are a treatment option for diabetic peripheral neuropathy (DPN). Existing evidence demonstrates the prolonged use of TCA therapy increases the risk of cognitive decline and dementia, likely due to the anticholinergic effects of these medications. The anticholinergic activity is thought to contribute significantly to the observed increase in cognitive decline and dementia risks associated with long-term TCA use. There is little information av ..read more

Trends Genet. 2024 May 4:S0168-9525(24)00078-7. doi: 10.1016/j.tig.2024.04.004. Online ahead of print. ABSTRACT Due to their capacity to mediate repetitive protein interactions, intrinsically disordered regions (IDRs) are crucial for the formation of various types of protein-RNA complexes. The functions of IDRs are strongly modulated by post-translational modifications (PTMs). Phosphorylation is the most common and well-studied modification of IDRs, which can alter homomeric or heteromeric interactions of proteins and impact their ability to phase separate. Moreover, phosphorylation can influ ..read more

Neuropharmacology. 2024 May 3:109987. doi: 10.1016/j.neuropharm.2024.109987. Online ahead of print. ABSTRACT Age is the largest risk factor for developing Alzheimer’s disease (AD), a neurodegenerative disorder that causes a progressive and severe dementia. The underlying cause of cognitive deficits seen in AD is thought to be the disconnection of neural circuits that control memory and executive functions. Insight into the mechanisms by which AD diverges from normal aging will require identifying precisely which cellular events are driven by aging and which are impacted by AD-related patholog ..read more