Neuronal activity drives glymphatic waste clearance
Nature Reviews Neurology
by Lisa Kiani
1w ago
Nature Reviews Neurology, Published online: 15 April 2024; doi:10.1038/s41582-024-00963-x Two new studies show that clearance of waste, including pathogenic amyloid, through the glymphatic system is driven by synchronized neuronal activity ..read more
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Neurofilaments as biomarkers in neurological disorders — towards clinical application
Nature Reviews Neurology
by Michael Khalil, Charlotte E. Teunissen, Sylvain Lehmann, Markus Otto, Fredrik Piehl, Tjalf Ziemssen, Stefan Bittner, Maria Pia Sormani, Thomas Gattringer, Samir Abu-Rumeileh, Simon Thebault, Ahmed Abdelhak, Ari Green, Pascal Benkert, Ludwig Kappos, Manuel Comabella, Hayrettin Tumani, Mark S. Freedman, Axel Petzold, Kaj Blennow, Henrik Zetterberg, David Leppert, Jens Kuhle
1w ago
Nature Reviews Neurology, Published online: 12 April 2024; doi:10.1038/s41582-024-00955-x Neurofilaments have been validated as specific body fluid biomarkers of neuro-axonal injury. In this Review, Khalil and colleagues provide an update on the structure and function of neurofilaments, analytical approaches and challenges in different clinical contexts, and progress towards clinical application of neurofilaments as a biomarker in various neurological disorders ..read more
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Addressing disparities in neurology by identifying gaps in hospital care
Nature Reviews Neurology
by Lisa Kiani
1w ago
Nature Reviews Neurology, Published online: 12 April 2024; doi:10.1038/s41582-024-00960-0 Nature Reviews Neurology is interviewing individuals who are driving efforts to address disparities in neurology through a broad spectrum of diversity, equity and inclusion initiatives. We spoke with neurosurgeon Sonia Mejía Pérez from Mexico about her work to address gaps in hospital care for individuals from minority groups, such as LGBT+ people ..read more
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EBV-specific T cells in multiple sclerosis
Nature Reviews Neurology
by Heather Wood
1w ago
Nature Reviews Neurology, Published online: 10 April 2024; doi:10.1038/s41582-024-00959-7 New data recently reported at the ACTRIMS Forum add to growing evidence of an aetiological role for Epstein–Barr virus infection in multiple sclerosis ..read more
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BTK inhibitor falters in multiple sclerosis trials
Nature Reviews Neurology
by Heather Wood
1w ago
Nature Reviews Neurology, Published online: 10 April 2024; doi:10.1038/s41582-024-00958-8 Findings of phase III trials of the Bruton’s tyrosine kinase inhibitor evobrutinib in patients with relapsing multiple sclerosis were recently presented at the ACTRIMS Forum ..read more
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Support for network theories of schizophrenia
Nature Reviews Neurology
by Martijn P. van den Heuvel, Sara L. Seoane
2w ago
Nature Reviews Neurology, Published online: 05 April 2024; doi:10.1038/s41582-024-00956-w A computational neuroimaging study has shed new light on the relationship between morphological changes in the brain in schizophrenia and the network architecture of the brain, providing evidence to support two network theories of the disorder ..read more
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Addressing disparities in neurology by building the workforce in LMICs
Nature Reviews Neurology
by Lisa Kiani
2w ago
Nature Reviews Neurology, Published online: 04 April 2024; doi:10.1038/s41582-024-00952-0 Nature Reviews Neurology is interviewing individuals who are driving efforts to address disparities in neurology through a broad spectrum of diversity, equity and inclusion initiatives. We spoke with stroke neurologist Nirali Vora from the USA about her work to build neurology capacity in low and middle-income countries ..read more
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Diversity, equity and inclusion in neurology
Nature Reviews Neurology
by
2w ago
Nature Reviews Neurology, Published online: 04 April 2024; doi:10.1038/s41582-024-00951-1 This month, Nature Reviews Neurology launches a Series to highlight the importance of diversity, equity and inclusion in the neurology community and in neurological care to address health disparities and thereby to improve global brain health ..read more
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Insights into epileptogenesis from post-traumatic epilepsy
Nature Reviews Neurology
by Matthew Pease, Kunal Gupta, Solomon L. Moshé, Daniel J. Correa, Aristea S. Galanopoulou, David O. Okonkwo, Jorge Gonzalez-Martinez, Lori Shutter, Ramon Diaz-Arrastia, James F. Castellano
2w ago
Nature Reviews Neurology, Published online: 03 April 2024; doi:10.1038/s41582-024-00954-y Post-traumatic epilepsy is a major driver of disability associated with traumatic brain injury. This article reviews the epidemiology and clinical features of post-traumatic epilepsy and discusses how an understanding of the underlying epileptogenic mechanisms might inform the development of anti-epileptogenic medications ..read more
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Neurostimulation for treatment of post-stroke impairments
Nature Reviews Neurology
by Jesse Dawson, Azmil H. Abdul-Rahim, Teresa J. Kimberley
2w ago
Nature Reviews Neurology, Published online: 03 April 2024; doi:10.1038/s41582-024-00953-z Various neurostimulation techniques are being explored for the treatment of physical impairments in people with stroke. This Review summarizes our current knowledge of the techniques that are now in clinical use or have reached the stage of pivotal trials alongside emerging techniques and highlights the need for further studies ..read more
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