Nature Chemical Biology, Published online: 26 April 2024; doi:10.1038/s41589-024-01609-1 A discovery pipeline integrating time-resolved HT-SAXS and fragment screening identifies chemical leads targeting exemplary allosteric states of mitochondrial oxidoreductase apoptosis-inducing factor (AIF ..read more

Nature Chemical Biology, Published online: 26 April 2024; doi:10.1038/s41589-024-01617-1 Setting the pace for degrons ..read more

Nature Chemical Biology, Published online: 26 April 2024; doi:10.1038/s41589-024-01616-2 Bacteria lose a pep in their step ..read more

Nature Chemical Biology, Published online: 26 April 2024; doi:10.1038/s41589-024-01615-3 Engineering from evolution ..read more

Nature Chemical Biology, Published online: 25 April 2024; doi:10.1038/s41589-024-01613-5 A tailored proteomics workflow to identify endogenous protein pyrophosphorylation in human cells was developed, revealing the dependence of the modification on inositol pyrophosphates and a putative function in rDNA transcription ..read more

Nature Chemical Biology, Published online: 25 April 2024; doi:10.1038/s41589-024-01596-3 A small-molecule iron mobilizer, FeM-1269, minimally higher-order aggregates in aqueous media and effectively mobilizes iron across a range of concentrations. FeM-1269-promoted iron mobilization restores physiology in animals at well-tolerated doses ..read more

Nature Chemical Biology, Published online: 25 April 2024; doi:10.1038/s41589-024-01606-4 Understanding the role of pyrophosphorylation requires specific analytical strategies to discriminate it from protein phosphorylation. A custom workflow reveals that nucleolar protein pyrophosphorylation in human cells regulates the transcription of ribosomal DNA ..read more

Nature Chemical Biology, Published online: 24 April 2024; doi:10.1038/s41589-024-01599-0 Cryo-electron microscopy (cryo-EM), kinetic analysis and single-molecule biochemistry reveal how the tubulin tyrosine ligase-like 6 (TTLL6) glutamylase binds reads microtubule geometry and modification state of neighboring tubulins, enabling a spatial positive feedback loop for microtubule modification ..read more

Nature Chemical Biology, Published online: 22 April 2024; doi:10.1038/s41589-024-01611-7 The mechanisms of stalled fork degradation in BRCA1/2-deficient cells remain unclear. UFL1, an UFM1-specific E3 ligase, was found to catalyze PTIP UFMylation at lysine 148, promoting stalled fork degradation by the MRE11 nuclease ..read more

Nature Chemical Biology, Published online: 22 April 2024; doi:10.1038/s41589-024-01560-1 Addendum: Designing microbial consortia with defined social interactions ..read more