Nature Chemical Biology, Published online: 22 April 2024; doi:10.1038/s41589-024-01611-7 The mechanisms of stalled fork degradation in BRCA1/2-deficient cells remain unclear. UFL1, an UFM1-specific E3 ligase, was found to catalyze PTIP UFMylation at lysine 148, promoting stalled fork degradation by the MRE11 nuclease ..read more

Nature Chemical Biology, Published online: 22 April 2024; doi:10.1038/s41589-024-01560-1 Addendum: Designing microbial consortia with defined social interactions ..read more

Nature Chemical Biology, Published online: 22 April 2024; doi:10.1038/s41589-024-01623-3 Author Correction: Fructose-1,6-bisphosphatase 1 dephosphorylates and inhibits TERT for tumor suppression ..read more

Nature Chemical Biology, Published online: 19 April 2024; doi:10.1038/s41589-024-01605-5 Ribosomally synthesized and post-translationally modified peptide (RiPP) natural products typically rely on substrate recognition through remote protein–protein interaction sites. Now, an atypical dehydratase, whose activity is directed by neighboring azole modifications, has been shown to produce a highly modified peptide hybrid bearing dehydroamino acids, enabling the synthesis of members of the dehydrazole family of RiPPs ..read more

Nature Chemical Biology, Published online: 18 April 2024; doi:10.1038/s41589-024-01604-6 Reprogramming intercellular mechanotransduction and signaling pathways is still challenging. A recent advance uses a plug-and-play DNA nanodevice to allow non-mechanosensitive receptor tyrosine kinase (RTK) to transmit force-induced cellular signals ..read more

Nature Chemical Biology, Published online: 17 April 2024; doi:10.1038/s41589-024-01580-x Developing disease-modifying drugs for neurodegenerative diseases has been very challenging. Now a machine learning approach has been used to identify small molecule inhibitors of α-synuclein aggregation, a process implicated in Parkinson’s disease and other synucleinopathies. Compounds that bind to the catalytic sites on the surface of the aggregates were identified and then progressively optimized into secondary nucleation inhibitors ..read more

Nature Chemical Biology, Published online: 05 April 2024; doi:10.1038/s41589-024-01608-2 Peptide vaccines use antigenic peptide fragments to induce an immune response but are problematic because of the short half-life of peptides. A study now reports thioamide substitution in the peptide backbone as a strategy to enhance resistance to proteolysis and promote binding to the MHC I complex for T cell activation ..read more

Nature Chemical Biology, Published online: 01 April 2024; doi:10.1038/s41589-024-01589-2 Detection of intracellular lipolysaccharide (LPS) activates an immune response initiated by the non-canonical inflammasome. ATGL has now been identified as a negative regulator of this pathway that dampens inflammation by removing LPS’ acyl chains, preventing the activation of inflammatory caspases and cytokines ..read more

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