Gastroenterology Insights, Vol. 15, Pages 409-418: p16 Expression in Multinucleated Stromal Cells of Fibroepithelial Polyps of the Anus (FEPA): A Comprehensive Review and Our Experience Gastroenterology Insights doi: 10.3390/gastroent15020029 Authors: Milena Gulinac Tsvetelina Velikova Latchezar Tomov Dorian Dikov Fibroepithelial polyps of the anus (FEPA) are a common benign polypoid proliferation of the stroma covered by squamous epithelium. They are also an often-overlooked part of pathological practice. Currently, immunohistochemistry (IHC) for p16 is the only recommended test for anal intr ..read more

Gastroenterology Insights, Vol. 15, Pages 419-432: Pruritus, Fatigue, Osteoporosis and Dyslipoproteinemia in Pbc Patients: A Clinician’s Perspective Gastroenterology Insights doi: 10.3390/gastroent15020030 Authors: Sylvia Drazilova Tomas Koky Marian Macej Martin Janicko Dagmar Simkova Ariunzaya Tsedendamba Slavomira Komarova Peter Jarcuska In this review article, we summarize the most common clinical manifestations of Primary biliary cholangitis (PBC): pruritus, fatigue, osteoporosis, and dyslipoproteinemia and discuss their impact of the patients’ quality of life. More ..read more

Gastroenterology Insights, Vol. 15, Pages 433-446: Assessment of Cognitive Function in Romanian Patients with Chronic Alcohol Consumption Gastroenterology Insights doi: 10.3390/gastroent15020031 Authors: Shandiz Morega Claudiu-Marinel Ionele Mihaela-Andreea Podeanu Dan-Nicolae Florescu Ion Rogoveanu Alcoholism presents a significant health concern with notable socioeconomic implications. Alcohol withdrawal syndrome (AWS) can manifest when individuals cease or drastically reduce their alcohol consumption after prolonged use. Non-alcoholic fatty liver disease (NAFLD) is characterized by substant ..read more

Gastroenterology Insights, Vol. 15, Pages 386-395: Effect of Concomitant Use of Polaprezinc and Vonoprazan-Based Triple Therapy for Helicobacter pylori Eradication Gastroenterology Insights doi: 10.3390/gastroent15020027 Authors: Yuto Suzuki Yasumi Katayama Yo Fujimoto Koji Toyoda Morio Takahashi Masaya Tamano Background: Vonoprazan-based triple therapy has recently been reported as being more effective than proton pump inhibitors for the eradication of Helicobacter pylori (H. pylori), but it is apparent that the eradication rate could be further improved. Methods: We investigated the effect o ..read more

Gastroenterology Insights, Vol. 15, Pages 375-385: Endoscopic Ultrasonography-Guided Fine-Needle Biopsy for Patients with Resectable Pancreatic Malignancies Gastroenterology Insights doi: 10.3390/gastroent15020026 Authors: Ming-Sheng Chien Ching-Chung Lin Jian-Han Lai Clinicians often use endoscopic ultrasonography to survey pancreatic tumors. When endoscopists conduct this examination and find the tumor to be unresectable, a fine-needle biopsy is subsequently performed for tissue confirmation. However, if the tumor is deemed resectable, the necessity of a pre-operative fine-needle biopsy rema ..read more

Gastroenterology Insights, Vol. 15, Pages 366-374: Identification of an Objective Cut-Off Point to Define the Clinical Stage T4a in Colon Cancer Gastroenterology Insights doi: 10.3390/gastroent15020025 Authors: Carolina Bautista-Saiz Luisa F. Rivera-Moncada Leonardo S. Lino-Silva Guillermo A. Pérez-Correa Pedro Frías-Fernández Introduction: The current state of pathology practice and the variability in diagnosing pT4a colon cancer have been underexplored in existing studies. Our objective was to establish a specific cutoff point to distinguish between the pathological stages of pT3 and pT4a in ..read more

Gastroenterology Insights, Vol. 15, Pages 354-365: Oral L-Citrulline Supplementation Improves Fatty Liver and Dyslipidemia in Adolescents with Abdominal Obesity: A Parallel, Double-Blind, Randomized Clinical Trial Gastroenterology Insights doi: 10.3390/gastroent15020024 Authors: Verónica Ivette Tovar-Villegas Yejin Kang Lorena del Rocío Ibarra-Reynoso Montserrat Olvera-Juárez Armando Gomez-Ojeda Víctor Manuel Bosquez-Mendoza Miriam Lizette Maldonado-Ríos Ma. Eugenia Garay-Sevilla Arturo Figueroa Obesity in adolescents is associated with non-communicable risk factors and diseases like metabolic ..read more

Gastroenterology Insights, Vol. 15, Pages 342-353: Duodenal Adenocarcinoma: The Relationship between Type of Surgery and Site of Recurrence in a Spanish Cohort Gastroenterology Insights doi: 10.3390/gastroent15020023 Authors: Gerardo Blanco-Fernández Daniel Aparicio-López Celia Villodre Isabel Jaén-Torrejimeno Cándido F Alcázar López Diego López-Guerra Mario Serradilla-Martín José M. Ramia We present a multicenter retrospective study of patients undergoing surgery for duodenal adenocarcinoma, from January 2010 to August 2020, in order to determine the epidemiological characteristics and the on ..read more

Gastroenterology Insights, Vol. 15, Pages 303-341: The Pathogenesis of Pancreatitis and the Role of Autophagy Gastroenterology Insights doi: 10.3390/gastroent15020022 Authors: Ioannis Tsomidis Argyro Voumvouraki Elias Kouroumalis The pathogenesis of acute and chronic pancreatitis has recently evolved as new findings demonstrate a complex mechanism operating through various pathways. In this review, the current evidence indicating that several mechanisms act in concert to induce and perpetuate pancreatitis were presented. As autophagy is now considered a fundamental mechanism in the pathophysio ..read more

Gastroenterology Insights, Vol. 15, Pages 285-302: Prevention of Musculoskeletal Injuries in Gastrointestinal Endoscopists Gastroenterology Insights doi: 10.3390/gastroent15020021 Authors: Tadej Durič Ivana Cibulkova Jan Hajer Gastroenterologists are exposed daily to musculoskeletal (MSK) stress during upper and lower gastrointestinal endoscopy, both during routine endoscopies and during long, demanding therapeutic procedures. There is evidence that endoscopy-related MSK injuries are becoming more common, particularly in the back, neck, shoulders, elbows, and hands. The aims of this study were ..read more