Thinning of the Sattler choroidal layer, intraretinal fluid, and the perfusion characteristics of macular neovascularization (MNV) are among the signs that indicate risk of worse morphological and functional outcome of neovascular age-related macular degeneration (AMD) and outer retinal atrophy, according to research published in Ophthalmology and Therapy. Additionally, a late switch in the type of anti-vascular endothelial growth factor (anti-VEGF) treatment, and the overall number of anti-VEGF injections, affect the risk of outer retinal atrophy. Optical coherence tomography (OCT)-based biom ..read more

Renal and thyroid cancer rates are 16% and 10% higher, respectively, in patients with age-related macular degeneration (AMD), according to research published in the British Journal of Ophthalmology. These patients also experience a higher risk of nerve tumors and skin cancer, but a reduced risk of stomach cancer, the study shows. Previous research has indicated that there is a relationship between AMD and cancer, but no study has pinpointed particularly related forms of cancer. The researchers utilized data of 4,088,814 individuals who were part of the Korean National Health Insurance Service ..read more

Scleral buckle (SB) for patients who have experienced a retinal detachment has an 83.7% primary reattachment success rate, according to the findings from the 18-year Moorfields Buckle Study, as reviewed in the journal Retina. The research links success rates with the physician’s surgical experience and suggests more robust training in, and exposure to. scleral buckle surgeries. The study took place at Moorfields Eye Hospital in London and included 589 eyes of 569 patients with rhegmatogenous retinal detachment (RRD). Participants underwent SB procedures from 2004 to 2022. In all, 76.1% present ..read more

Brolucizumab adverse events have occurred in 3.4% of adult eyes with neovascular age-related macular degeneration (nAMD), according to a real world review of the Intelligent Research in Sight (IRIS®) registry, a study published in Ophthalmology and Therapy shows. Patient age, sex, and prior anti-vascular endothelial growth factor (VEGF) therapy can affect a patient’s likelihood of experiencing an adverse event, the study adds. Prior studies have shown a risk of brolucizumab adverse events such as retinal vasculitis (RV) or retinal vascular occlusion (RO) adverse events. In this study, research ..read more

Among 8 agents, nepafenac and bromfenac are the most effective topical non-steroidal anti-inflammatory drugs (NSAIDs) for reducing pain caused by intravitreal injections (IVI), according to research published in Retina. Prior research has assessed what affects the level of pain patients who receive IVI and how topical NSAIDs can reduce that pain. In this study, researchers compared the effects of various NSAIDs, both immediately after and hours after IVI utilization. The researchers randomly divided 662 patients (662 eyes) who underwent IVI at a university teaching hospital in Turkey into a co ..read more

A technique employing internal limiting membrane (ILM) flaps in the treatment of macular holes larger than 500 µm can increase closure success, according to a retrospective study published in Eye. Two teams of investigators compared success rates of ILM flaps to that of ILM peeling using data collected between June 2018 and June 2022.  The retrospective study was an interventional analysis of data collected about 191 eyes that underwent repair of large idiopathic full-thickness macular holes (iFTMH). The investigators worked to determine if surgical variations improved outcomes of macular ..read more

Preterm children who are treated for retinopathy of prematurity (ROP) have thinner choroids than full-term children, and choroidal thickness decreases more in preterm children, even if they have no history of ROP, compared with full-term children, researchers report in a Retina publication. These findings held true regardless of whether the preterm children treated for ROP underwent intravitreal bevacizumab (IVB) injections or laser therapy. Researchers conducted a study to investigate how prematurity, ROP, and different types of retinopathy of prematurity treatments affect changes in choroida ..read more

A 22-year-old woman presented to the emergency department for evaluation of a new-onset central blurred spot in the left eye that same morning and that is constant. She stated that when she looked at words with the left eye, some of the letters were missing. Notably, she had the onset of a sore throat a few days prior to presentation, and one month prior, she was diagnosed with bilateral viral conjunctivitis. She had no other significant medical or ocular history and was not on any treatments except for birth control.  On examination, her visual acuity was 20/20 OD and 20/30+3 OS. P ..read more

Scleral buckle (SB) without pars plana vitrectomy (PPV) is an effective initial treatment approach for retinal dialysis, according to research presented at the American Society of Cataract and Refractive Surgery (ASCRS) 2024 Annual Meeting, held in Boston from April 5 to April 8, 2024. This treatment strategy has a low rate of cataract formation, according to the report.  Landon J. Rohowetz, MD, and colleagues reported on the surgical approaches and outcomes in patients undergoing surgery for retinal detachment associated with retinal dialysis. Retinal detachment associated with reti ..read more

In twins, retinopathy of prematurity (ROP) severity risk factors may have a lower threshold than single birth infants, according to research published in the International Journal of Retina and Vitreous. Twins or other multi birth neonates are at high risk of severe ROP at older gestational ages, higher birth weights, and lower supplemental oxygen duration than single born infants, according to the report. This study included 521 premature neonates (180 singletons, 170 twins, 171 triplets) with ROP who were born at 1 clinic in Iran between 2020 and 2023. Each was born at 34 weeks or earlier an ..read more