Researchers developed a novel nanoparticle that can cross the blood-brain barrier to target both primary breast tumors and brain metastases simultaneously. This dual-action approach utilizes a biodegradable polymer loaded with two prodrugs targeting cancer cell mitochondria ..read more

A novel study sheds new light on the link between the APOE4 gene and Alzheimer’s disease. The study reveals that over 95% of individuals over 65 who have two copies of the APOE4 gene exhibit biological markers of Alzheimer's in the brain or through cerebrospinal fluid and PET scans ..read more

Researchers discovered that the brain can significantly influence the immune system, particularly its inflammatory responses. The study utilized mice to show that the brain can detect and adjust levels of inflammation via a specific brain circuit involving the caudal nucleus of the solitary tract ..read more

Researchers uncovered how the influenza virus may infiltrate the brain, leading to a serious condition known as influenza-associated encephalopathy (IAE). The study identifies endothelial cells, which form the blood-brain barrier, as the primary entry points for the virus ..read more

Researchers introduced a new mRNA cancer vaccine that rapidly activates the immune system against glioblastoma, the deadliest form of brain tumor. This new vaccine technology, which mimics the structure of COVID-19 vaccines but incorporates personalized tumor cells and a complex cluster delivery system, has shown promising results in preclinical models and an initial human trial involving four adult patients ..read more

Remembering past anger can significantly impair blood vessel function, crucial for maintaining healthy blood flow. The study involved 280 adults who underwent emotional tasks that induced feelings of anger, anxiety, or sadness, and their vascular responses were measured ..read more

Researchers have pioneered a method to enhance the generation of dopaminergic neurons, crucial for Parkinson’s disease treatment, by targeting specific receptors within the Wnt signaling pathway. Using synthetic antibodies, the team successfully directed stem cell differentiation in the midbrain to produce these key neurons, which are instrumental in brain health and depleted in Parkinson’s patients ..read more

A new study uncovered how diets high in saturated fats contribute to the development of Alzheimer’s disease by affecting crucial molecular markers in the brain and blood. The research utilized mouse models to investigate the impact of such diets on the expression of miRNAs related to insulin regulation, revealing significant metabolic deterioration and brain inflammation ..read more

Researchers developed innovative, flexible devices that can gently wrap around nerve fibers, potentially transforming the diagnosis and treatment of neurological disorders. These tiny, flexible "nerve cuffs" employ soft robotics and flexible electronics to interface with peripheral nerves without causing damage ..read more

Researchers made a significant breakthrough in ALS treatment using a new gene therapy, marking a notable slow in disease progression for a patient with an aggressive form of ALS. The patient, treated since early 2020, has maintained much of their physical and social abilities, exceeding typical life expectancy and functionality projections for their condition ..read more