High-throughput Droplet Microfluidics Enables Discovery of Novel Mini Proteins
uFluidix Blog
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1w ago
In the continuous search to understand life's origins and harness biotechnology's potential, scientists have made a new discovery using high-throughput droplet microfluidics: a minimalist enzyme, derived from a library of de novo designed proteins, exhibiting remarkable biological activity. This enzyme, named mini-cAMPase, challenges our understanding ..read more
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New Approaches to Vascularization in Organoid Cultures Using Microfluidic Devices
uFluidix Blog
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1w ago
In tissue engineering, the creation of a vascular network within organoids that can efficiently supply nutrients and oxygen while removing waste is a significant challenge. Most tissues thicker than 400 µm require such a network to prevent necrosis. Traditionally, organoids are often transplanted into host ..read more
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Advancing Cardiac Tissue Engineering: Microfluidic Systems and Heart ECM Integration
uFluidix Blog
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3w ago
Recent advancements in the field of tissue engineering have yielded a novel culture system that significantly enhances the fabrication of human cardiac tissues. This system integrates a microfluidic platform with a heart extracellular matrix (HEM) hydrogel, designed to foster the maturation of tissues that more closely ..read more
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Precise Single-Cell Analysis through On-Chip Fiber Optics
uFluidix Blog
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1M ago
The ability to analyze individual cells allows scientists to uncover a wealth of information hidden in the cellular heterogeneity of tissues, leading to breakthroughs in understanding diseases and developing targeted treatments. However, despite the critical importance of this research, traditional methods of single-cell analysis, particularly ..read more
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Integrating Functional Vascularized Organoids-on-Chip
uFluidix Blog
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3M ago
Recent advancements in tissue engineering and organ-on-chip technology have led to the development of a novel microfluidic platform designed for the encapsulation and long-term culture of various types of cell aggregates with an emphasis on vascularization. This microfluidic chip represents a step forward in addressing ..read more
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Bridging Nature and Technology: Precision Engineering of Spider Silk with Microfluidics
uFluidix Blog
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3M ago
The marvel of spider silk, with its unmatched strength, elasticity, and biodegradability, has long captivated scientists and engineers. The quest to synthesize spider silk outside of its natural context has faced numerous challenges, primarily due to the complex molecular processes involved. However, a groundbreaking study ..read more
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Exploring the Mechanics of Cancer Cell Metastasis Through Microfluidics
uFluidix Blog
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3M ago
In the fight against cancer, understanding the mechanics of metastasis—the process by which cancer spreads from one part of the body to another—is crucial. Cancer metastasis is a complex process that involves more than just the genetic and biochemical makeup of cancer cells; the physical ..read more
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Study of Eccrine Sweat Gland Development Using Microfluidic Chips Fabricated at uFluidix
uFluidix Blog
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3M ago
Eccrine sweat glands are vital for human thermoregulation and, like other mammalian skin appendages, originate from multipotent epidermal progenitors. This research, leveraging advanced microfluidic technology, offers fascinating insights into the intricacies of eccrine gland formation and its potential applications in dermatology and regenerative medicine. "Our study ..read more
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Beyond Poisson Statistics: Enhancing Microfluidic Single-Cell Encapsulation
uFluidix Blog
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4M ago
In the ever-evolving world of microfluidics, the study of single-cells has become a cornerstone for studying diseases and for therapeutic development. A recent paper published in the Microsystems and Nanoengineering journal "Enhancing Single-Cell Encapsulation in Droplet Microfluidics with Fine-Tunable On-Chip Sample Enrichment," presents a study ..read more
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Microfluidics and CRISPR in Syncytium Formation: Investigating SARS-CoV-2 Spike Protein Mechanisms
uFluidix Blog
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5M ago
As the world continues to grapple with the challenges of COVID-19, scientists are delving deeper into the virus's behavior at a cellular level. A pivotal study published in Nature Biomedical Engineering has made significant strides in understanding how the SARS-CoV-2 spike protein induces the formation ..read more
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