Navigating Autophagy: A Path to Drug Discovery
Life Chemicals Blog » Computational Chemistry
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1M ago
Autophagy is crucial for maintaining cellular homeostasis by removing damaged organelles, protein aggregates, and intracellular pathogens. Recent advancements in autophagy drug discovery are paving the way for novel therapeutic approaches. We are offering a dedicated Autophagy Screening Compound Library of over 6,200 autophagy-associated screening compounds ..read more
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Helicases in drug discovery
Life Chemicals Blog » Computational Chemistry
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2M ago
Driving innovative drug development technologies through targeting helicases, Life Chemicals has designed dedicated Screening Sets of potential helicase inhibitors and related screening compound libraries ..read more
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Fluorine Fragment Cocktails in Fragment-Based Drug Discovery
Life Chemicals Blog » Computational Chemistry
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4M ago
Our dedicated products, such as the Fluorine Fragment Cocktail Library and the Fluorine Fragment Library, offer valuable resources and advantages for applying fluorine fragment cocktails to various FBDD projects ..read more
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Molecular Degraders for Targeted Protein Degradation
Life Chemicals Blog » Computational Chemistry
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8M ago
Selective targeted protein degradation emerge as a new approach for the development of more effective and precise drugs. At Life Chemicals, we offer tools and services for crafting new molecular glue degraders like PPI inhibitors, PROTACs, and RIBOTACs ..read more
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Signal Pathways in Drug Discovery
Life Chemicals Blog » Computational Chemistry
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10M ago
Life Chemicals offers small drug-like screening libraries with potential activity against various targets involved in signal cascades aimed for various drug discovery projects: apoptosis signaling, PI3K/Akt/mTOR, RAS/MAPK ..read more
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Nuclear Receptors in Drug Discovery
Life Chemicals Blog » Computational Chemistry
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1y ago
Nuclear receptors are a class of proteins that play an essential role in the regulation of gene expression. Nuclear receptor-based drugs hold great potential for the treatment of various diseases. In this connection, Life Chemicals offers a collection of dedicated Screening Libraries ..read more
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Measuring Structural Diversity for Screening Compound Libraries
Life Chemicals Blog » Computational Chemistry
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1y ago
Research efforts that seek to prioritize the selection of screening compound libraries or sub-libraries for experimental evaluation can take advantage of chemical diversity to increase the probability of finding new scaffolds ..read more
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Advantages of 3D-shape of ligands in drug discovery
Life Chemicals Blog » Computational Chemistry
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1y ago
Rapidly developing structure-based drug design (SBDD) is mainly based on various computational techniques, which allow for the automation and acceleration of the drug design workflow. Life Chemicals offers its proprietary collection of 3D-shaped and Fsp3-enriched screening compounds for efficient drug discovery ..read more
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Transcription-related Targets in Drug Discovery
Life Chemicals Blog » Computational Chemistry
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1y ago
Transcription factors are involved in various diseases, including cancer, diabetes, neurological, autoimmune, inflammatory disorders, cardiovascular disease, and parasitic infections. To promote the transcription-related drug discovery, Life Chemicals presents distinctive collections of drug-like screening compounds competent for TF modulation research ..read more
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Phenotypic and target-based HTS in drug discovery
Life Chemicals Blog » Computational Chemistry
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1y ago
Given the complementary benefits and capabilities of the two screening methods, Life Chemicals considers both approaches for creating the most diverse and balanced collection of screening compound libraries for HTS efforts in drug discovery ..read more
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