Alithea Genomics Blog
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News and Views from Alithea Genomics
Alithea Genomics Blog
2w ago
Ultra-low input RNA-seq library preparation methods like our MERCURIUS™ High Sensitivity BRB-seq kit provide researchers with powerful tools to explore the transcriptomes of small cell populations or precious clinical samples where extracted RNA quantities are minimal. ..read more
Alithea Genomics Blog
4M ago
A core goal of large-scale drug discovery screens is to use the transcriptomic effects of novel compounds on cells as indicators of both drug toxicity and potential mechanisms of action ..read more
Alithea Genomics Blog
5M ago
Ion AmpliSeq™ from Thermo Fisher Scientific is a targeted PCR-based transcriptome profiling technology that allows users to measure the expression levels of over 20,000 genes, even in challenging low-quantity or degraded RNA samples such as from formalin-fixed paraffin-embedded (FFPE) tissue ..read more
Alithea Genomics Blog
5M ago
MERCURIUS™ formalin-fixed paraffin-embedded sequencing (FFPE-seq) is a scalable and cost-effective full-length bulk RNA sequencing technology optimized for heavily degraded RNA samples with RNA integrity numbers (RIN) as low as 1 ..read more
Alithea Genomics Blog
6M ago
QuantiGene™ Plex Gene Expression Assays from Invitrogen™ use hybridization-probe-based branched DNA technology to simultaneously quantify up to 80 known genes of interest per well of a 96- or 384-well plate ..read more
Alithea Genomics Blog
7M ago
After almost thirty years since the first commercial prototype of the Affymetrix™ GeneChip™ microarray hit the market in 1994, its impact on our understanding of the intricate role of gene expression in health and disease remains staggering ..read more
Alithea Genomics Blog
7M ago
Clariom™ assays from Applied Biosystems™ use microarray technology to facilitate broad or targeted transcriptome analysis to identify crucial biomarkers, biological pathways, and complex gene expression signatures suited to diverse user needs ..read more
Alithea Genomics Blog
7M ago
Determining the transcriptomic effects of novel compounds on cells for large-scale therapeutic or toxicology screens is a critical component of drug development pipelines, allowing researchers to assess the on- or off-target effects of a drug, its toxicity, and possible mechanisms of action ..read more
Alithea Genomics Blog
7M ago
Templated Oligo assay with Sequencing readout (TempO-Seq™) is a ligation-based targeted whole transcriptome expression profiling assay designed to maximize the utilization of precious or limited samples for high-throughput toxicogenomic or drug discovery pipelines (Yeakley et al., 2017 ..read more
Alithea Genomics Blog
10M ago
Determining the most suitable transcriptomic technology to drive your large-scale compound screen, clinical study, or to assess a panel of genetic perturbations can be a headache, especially if you’re unfamiliar with the strengths and limitations of various sequencing technologies ..read more