Orphan receptor-GPR52 inverse agonist efficacy in ameliorating chronic stress-related deficits in reward motivation and phasic accumbal dopamine activity in mice ..read more

Drug repurposing for Parkinson’s disease by biological pathway based edge-weighted network proximity analysis ..read more

Agonist antibody to guanylate cyclase receptor NPR1 regulates vascular tone Durable agonism of NPR1 achieved with a novel investigational monoclonal antibody could mirror the positive hemodynamic changes in blood pressure and heart failure identified in humans with lifelong exposure to ..read more

Oxytocin decreases alcohol self-administration in male baboons ..read more

Label-free assessment of complement-dependent cytotoxicity of therapeutic antibodies via a whole-cell MALDI mass spectrometry bioassay ..read more

MCL1 inhibitor BRD-810 kills cancer cells while minimizing risk of cardiotoxicity The anti-apoptotic protein MCL1 is a therapeutic target in cancer, but long-term MCL1 inhibition has been found to increase the risk of cardiotoxicity. We developed BRD-810 as a potent and selective MCL1 inhibitor that induces cancer cell death in vivo within a few hours. As BRD-810 was designed to be rapidly cleared, it targets cancer cells while minimizing the risk for cardiotoxicity ..read more

-MDMA, and racemic MDMA in a randomized double-blind cross-over trial in healthy participants ..read more

Still controversial issues on assessing anhedonia in experimental modeling of depression ..read more

Lidocaine and risk of postoperative vomiting in children undergoing tonsillectomy: a randomised clinical trial ..read more

Structural basis of frizzled 7 activation and allosteric regulation is a class F GPCR involved in intestinal epithelium homeostasis. Using cryo-EM, the authors determine the structure of inactive FZD and compare it with the G-protein-bound form. They refine the FZD activation mechanisms and identify a water pocket and an allosteric cholesterol binding site ..read more