The latest release (version 2024.2) of the IUPHAR/BPS Guide to Pharmacology database has been made. Released on 26th June 2024 this is the second release of the year. The following blog post gives details of the key content updates and website changes. GtoPdb now contains: 3,083 human targets, 1,744 of which have curated quantitative ligand interactions. 12,730 ligands, 9,292 of which have curated quantitative target interactions. 1,995 approved drugs, 1,133 with curated quantitative interactions. Clinical use summaries for 3,770 ligands, of which 1,985 are approved drugs. A total of 20,949 c ..read more

The essential guide for those working in the vital search for new drugs A FREE education and research resource What’s in it for you? Published as a special issue in the British journal of Pharmacology every 2 years, The Concise Guide to PHARMACOLOGY provides brief overviews of the key properties of over 1,800 human drug targets and their pharmacology, and is a view of the data in the IUPHAR/BPS Guide to PHARMACOLOGY that allows side by side comparison of members of families of drug targets. As a go to place for finding the best tools to use in the laboratory for any targets ..read more

The IUPHAR/BPS Guide to Pharmacology is delighted to be named as one of 15 new Global Core Biodata Resources (GCBRs) by the Global Biodata Coalition (GBC). The GBC announced the outcome of its 2023 selection round for GCBRs on 11th December 2023 – you can read about the announcement here. GtoPdb is proud to meet the stringent eligibility criteria that were part of the selection process. This covered scientific focus, size and reach of the user communities, quality of service, governance and impact on global research.  The inclusion of the 15 new resources brings the total number of GCBrs ..read more

The latest release of the IUPHAR/BPS Guide to Pharmacology database was made on 29th November 2023. This database release is version 2023.3, and is the third release this year. The following blog post gives details of the key content updates and website changes. GtoPdb now contains: 3,056 human targets, 1,715 of which have curated quantitative ligand interactions. 12,344 ligands, 9,072 of which have curated quantitative target interactions. 1,956 approved drugs, 1,117 with curated quantitative interactions. Clinical use summaries for over 3,596 ligands of which 1,947 are approved drugs ..read more

The latest release of the IUPHAR/BPS Guide to Pharmacology database was made on 7th August 2023. This database release is version 2023.2, and is the second release this year. The following blog post gives details of the key content updates and website changes. GtoPdb now contains: 3,039 human targets, 1,695 of which have curated quantitative ligand interactions. 12,163 ligands, 8,959 of which have curated quantitative target interactions. 1,918 approved drugs, 1,107 with curated quantitative interactions. Clinical use summaries for over 3,494 ligands of which 1,910 are approved drugs. A ..read more

The latest release of the IUPHAR/BPS Guide to Pharmacology database was made on 26th April 2023. This database release is version 2023.1, and is the first release this year. The following blog post gives details of the key content updates and website changes. GtoPdb now contains: 3,023 human targets, 1,662 of which have curated quantitative ligand interactions. 11,944 ligands, 8,814 of which have curated quantitative target interactions. 1,872 approved drugs, 1,098 with curated quantitative interactions. Clinical use summaries for over 3,385 ligands of which 1,866 are approved drugs. A t ..read more

We wish to offer our congratulations to Professor Jamie Davies, Professor of Experimental Anatomy, University of Edinburgh, who has been elected to the Cymdeithas Ddysgedig Cymru/Learned Society of Wales. The society’s new Fellows include academics from across Welsh and UK universities, writers, researchers and leaders from the world of higher education, as well as law, medicine and the media Jamie has led the IUPHAR/BPS Guide to PHARMACOLOGY database since 2014, having taken over from Professor Tony Harmar, and has been instrumental in the launch of IUPHAR Guide to IMMUNOPHARMACOLOGY and IUPH ..read more

These are some of the ligands under curation (pre-release) in the Guide to Pharmacology. We expect them to be available on the website at the next database release (2020.3). Ligand ID: 10891 Name: aviptadil Comment: Aviptadil is a vasoactive intestinal peptide analogue, VPAC1 receptor agonist. The HELM annotation for aviptadil is PEPTIDE1{H.S.D.A.V.F.T.D.N.Y.T.R.L.R.K.Q.M.A.V.K.K.Y.L.N.S.I.L.N}$$$$. Ligand ID: 10745 Name: MDL-28170 IUPAC: benzyl N-[(2S)-3-methyl-1-oxo-1-[[(2S)-1-oxo-3-phenylpropan-2-yl]amino]butan-2-yl]carbamate Comment: PRD_002214 is a peptide-like inhibitor of the main pro ..read more

These are some of the ligands under curation (pre-release) in the Guide to Pharmacology. We expect them to be available on the website at the next database release (2020.2 – no earlier than April 2020).  Ligand ID: 10716 Name: PRD_002214 IUPAC: benzyl (2Z,4S)-4-[(2S)-4-methyl-2-[(2S)-3-methyl-2-[(2S)-2-[(5-methyl-1,2-oxazol-3-yl)formamido]propanamido]butanamido]pentanamido]-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate RCSB PDB: PRD_002214 Comment: PRD_002214 is a peptide-like inhibitor of the main protease (MPRO) of SARS-CoV-2. The structure was obtained from the RCSB Protein Data Bank e ..read more

Melatonin targets two high-affinity receptors, MT1 and MT2, that belong to the G protein-coupled receptor (GPCR) superfamily (1,2). Drugs acting on melatonin receptors are subscribed for circadian disorders (jet lag, shift work, etc.), insomnia and major depression (3). All marketed drugs are non-selective agonists targeting both receptor types so far. Despite large chemical synthesis campaigns over the last 20 years, the pharmacology of melatonin receptors remains poorly explored with few inverse agonistic and signaling pathway-biased compounds and few  selective compounds, in particular ..read more