Nature Medicine
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Original research articles published in Nature Medicine range from basic findings that have clear implications for disease pathogenesis and therapy to the earliest phases of human investigation. Aiming to keep Ph.D. and M.D. readers informed of a wide range of biomedical research findings, the journal publishes the latest advances in cancer biology, vascular biology, neuroscience, inflammatory..
Nature Medicine
3h ago
Nature Medicine, Published online: 14 May 2024; doi:10.1038/s41591-024-02973-0
Interim results from the low-dose cohort of the PROCLAIM trial show that AAV-based delivery of the progranulin gene in patients with frontotemporal dementia was safe and was associated with increased CSF progranulin ..read more
Nature Medicine
3h ago
Nature Medicine, Published online: 14 May 2024; doi:10.1038/s41591-024-02960-5
Cognitive variability with age has been examined in 21,051 recallable volunteers and has highlighted a potential role of microglia and glycogen metabolism in the individual differences in general cognitive ability ..read more
Nature Medicine
3h ago
Nature Medicine, Published online: 14 May 2024; doi:10.1038/s41591-024-03005-7
Data from pediatric populations with neurodevelopmental disorders, obtained through a combinatorial strategy of literature review scoping and in-patient appointments, were used to construct a Phenomics Aggregation Database (PhenomAD-NDD) that can aid clinical diagnosis of comorbidities ..read more
Nature Medicine
3h ago
Nature Medicine, Published online: 14 May 2024; doi:10.1038/s41591-024-02992-x
Exploratory analyses of the DESTINY-Gastric01 trial show that baseline HER2-associated biomarkers in circulating tumor DNA or tissue samples were associated with therapeutic response in patients with HER2-positive tumors, and these analyses identify potential drivers of resistance ..read more
Nature Medicine
3h ago
Nature Medicine, Published online: 13 May 2024; doi:10.1038/s41591-024-02974-z
Dapagliflozin improved a hierarchical composite outcome, including death, a worsening kidney disease event, and estimated glomerular filtration rate slope, compared with placebo, in patients with heart failure. This hierarchical outcome — analyzed with win statistics — might provide the statistical power to evaluate the effect of treatments on kidney function in heart failure trials ..read more
Nature Medicine
1d ago
Nature Medicine, Published online: 13 May 2024; doi:10.1038/d41591-024-00034-0
Enzymes produced by Akkermansia muciniphila generated group O blood by degrading A and B antigens, which could help solve blood donor shortages in the future ..read more
Nature Medicine
1d ago
Nature Medicine, Published online: 13 May 2024; doi:10.1038/s41591-024-02970-3
This Review outlines the state of the art of artificial intelligence in the preoperative, intraoperative and postoperative settings, where it has enormous potential to improve patient outcomes, surgical education and system efficiencies ..read more
Nature Medicine
1d ago
Nature Medicine, Published online: 13 May 2024; doi:10.1038/s41591-024-02944-5
Genome-wide analyses of vaccine antibody responses in 2,499 infants from Uganda, South Africa and Burkina Faso identify associations between specific HLA genes and response to eight vaccines, providing insights that could be considered for population-adjusted vaccine design strategies ..read more
Nature Medicine
1d ago
Nature Medicine, Published online: 13 May 2024; doi:10.1038/s41591-024-02929-4
In a prospective observational study, symptoms of anxiety and/or depression were associated with worse response to first-line treatment with immunotherapy in patients with advanced non-small-cell lung cancer ..read more
Nature Medicine
1d ago
Nature Medicine, Published online: 13 May 2024; doi:10.1038/s41591-024-02971-2
A two-step, video-based deep learning model is developed to first screen for cardiac anomalies using noncontrast magnetic resonance imaging, followed by diagnosis of 11 types of cardiovascular disease using gadolinium enhancement-based imaging ..read more