A Pfs48/45-based vaccine to block Plasmodium falciparum transmission: phase 1, open-label, clinical trial
BMC Medicine
by M. Alkema, M. J. Smit, C. Marin-Mogollon, K. Totté, K. Teelen, G. J. van Gemert, M. van de Vegte-Bolmer, B. G. Mordmüller, J. M. Reimer, K. L. Lövgren-Bengtsson, R. W. Sauerwein, T. Bousema, J. Plieskatt, M. Theisen, M. M. Jore and M. B. B. McCall
2d ago
The stalling global progress in malaria control highlights the need for novel tools for malaria elimination, including transmission-blocking vaccines. Transmission-blocking vaccines aim to induce human antibod ..read more
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Efficacy and safety of tislelizumab plus lenvatinib as first-line treatment in patients with unresectable hepatocellular carcinoma: a multicenter, single-arm, phase 2 trial
BMC Medicine
by Li Xu, Jinzhang Chen, Chang Liu, Xiaoling Song, Yanqiao Zhang, Haitao Zhao, Sheng Yan, Weidong Jia, Zheng Wu, Yabing Guo, Jiayin Yang, Wei Gong, Yue Ma, Xiaobo Yang, Zhenzhen Gao, Nu Zhang…
2d ago
Lenvatinib is widely used in treatment of unresectable hepatocellular carcinoma (uHCC), but the benefit of its combination with immunotherapy needs to be verified. This study evaluated the efficacy and safety ..read more
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Impact of perioperative low-molecular-weight heparin therapy on clinical events of elderly patients with prior coronary stents implanted > 12 months undergoing non-cardiac surgery: a randomized, placebo-controlled trial
BMC Medicine
by Bin Wang, Yanhui Su, Cong Ma, Lining Xu, Qunxia Mao, Wenjia Cheng, Qingming Lu, Ying Zhang, Rong Wang, Yan Lu, Jing He, Shihao Chen, Lei Chen, Tianzhi Li and Linggen Gao
2d ago
Little is known about the safety and efficacy of discontinuing antiplatelet therapy via LMWH bridging therapy in elderly patients with coronary stents implanted for > 12 months undergoing non-cardiac surgery ..read more
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Very short sleep duration reveals a proteomic fingerprint that is selectively associated with incident diabetes mellitus but not with incident coronary heart disease: a cohort study
BMC Medicine
by Thomas Svensson, Akiko Kishi Svensson, Mariusz Kitlinski, Gunnar Engström, Jan Nilsson, Marju Orho-Melander, Peter M. Nilsson and Olle Melander
2d ago
The molecular pathways linking short and long sleep duration with incident diabetes mellitus (iDM) and incident coronary heart disease (iCHD) are not known. We aimed to identify circulating protein patterns as ..read more
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Impact of COVID-19 pandemic on depression incidence and healthcare service use among patients with depression: an interrupted time-series analysis from a 9-year population-based study
BMC Medicine
by Vivien Kin Yi Chan, Yi Chai, Sandra Sau Man Chan, Hao Luo, Mark Jit, Martin Knapp, David Makram Bishai, Michael Yuxuan Ni, Ian Chi Kei Wong and Xue Li
2d ago
Most studies on the impact of the COVID-19 pandemic on depression burden focused on the earlier pandemic phase specific to lockdowns, but the longer-term impact of the pandemic is less well-studied. In this po ..read more
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Quantifying the impact of hospital catchment area definitions on hospital admissions forecasts: COVID-19 in England, September 2020–April 2021
BMC Medicine
by Sophie Meakin and Sebastian Funk
1w ago
Defining healthcare facility catchment areas is a key step in predicting future healthcare demand in epidemic settings. Forecasts of hospitalisations can be informed by leading indicators measured at the commu ..read more
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Lipid metabolic reprogramming mediated by circulating Nrg4 alleviates metabolic dysfunction-associated steatotic liver disease during the early recovery phase after sleeve gastrectomy
BMC Medicine
by Chengcan Yang, Dongzi Zhu, Chaofan Liu, Wenyue Wang, Yining He, Bing Wang and Meiyi Li
1w ago
The metabolic benefits of bariatric surgery that contribute to the alleviation of metabolic dysfunction-associated steatotic liver disease (MASLD) have been reported. However, the processes and mechanisms unde ..read more
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Olfactory bulb anomalies in KBG syndrome mouse model and patients
BMC Medicine
by Kara Goodkey, Anita Wischmeijer, Laurence Perrin, Adrianne E. S. Watson, Leenah Qureshi, Duccio Maria Cordelli, Francesco Toni, Maria Gnazzo, Francesco Benedicenti, Monique Elmaleh-Bergès, Karen J. Low and Anastassia Voronova
1w ago
ANKRD11 (ankyrin repeat domain 11) is a chromatin regulator and the only gene associated with KBG syndrome, a rare neurodevelopmental disorder. We have previously shown that Ankrd11 regulates murine embryonic cor ..read more
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What is quality in long covid care? Lessons from a national quality improvement collaborative and multi-site ethnography
BMC Medicine
by Trisha Greenhalgh, Julie L. Darbyshire, Cassie Lee, Emma Ladds and Jenny Ceolta-Smith
1w ago
Long covid (post covid-19 condition) is a complex condition with diverse manifestations, uncertain prognosis and wide variation in current approaches to management. There have been calls for formal quality sta ..read more
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Cervical lymph node metastasis prediction from papillary thyroid carcinoma US videos: a prospective multicenter study
BMC Medicine
by Ming-Bo Zhang, Zhe-Ling Meng, Yi Mao, Xue Jiang, Ning Xu, Qing-Hua Xu, Jie Tian, Yu-Kun Luo and Kun Wang
1w ago
Prediction of lymph node metastasis (LNM) is critical for individualized management of papillary thyroid carcinoma (PTC) patients to avoid unnecessary overtreatment as well as undesired under-treatment. Artifi ..read more
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