In vivo rescue of genetic dilated cardiomyopathy by systemic delivery of nexilin
BMC » Genome Biology
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2w ago
Dilated cardiomyopathy (DCM) is one of the most common causes of heart failure. Multiple identified mutations in nexilin (NEXN) have been suggested to be linked with severe DCM. However, the exact association ..read more
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ScCDC: a computational method for gene-specific contamination detection and correction in single-cell and single-nucleus RNA-seq data
BMC » Genome Biology
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2w ago
In droplet-based single-cell and single-nucleus RNA-seq assays, systematic contamination of ambient RNA molecules biases the quantification of gene expression levels. Existing methods correct the contamination ..read more
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Current status of community resources and priorities for weed genomics research
BMC » Genome Biology
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2w ago
Weeds are attractive models for basic and applied research due to their impacts on agricultural systems and capacity to swiftly adapt in response to anthropogenic selection pressures. Currently, a lack of geno ..read more
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Rosace: a robust deep mutational scanning analysis framework employing position and mean-variance shrinkage
BMC » Genome Biology
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2w ago
Deep mutational scanning (DMS) measures the effects of thousands of genetic variants in a protein simultaneously. The small sample size renders classical statistical methods ineffective. For example ..read more
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EPRINT: exonuclease assisted mapping of protein-RNA interactions
BMC » Genome Biology
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2w ago
RNA-binding proteins (RBPs) regulate key aspects of RNA processing including alternative splicing, mRNA degradation and localization by physically binding RNA molecules. Current methods to map these interactio ..read more
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Reproductive isolation arises during laboratory adaptation to a novel hot environment
BMC » Genome Biology
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2w ago
Reproductive isolation can result from adaptive processes (e.g., ecological speciation and mutation-order speciation) or stochastic processes such as “system drift” model. Ecological speciation predicts barrie ..read more
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X-chromosome inactivation in human iPSCs provides insight into X-regulated gene expression in autosomes
BMC » Genome Biology
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2w ago
Variation in X chromosome inactivation (XCI) in human-induced pluripotent stem cells (hiPSCs) can impact their ability to model biological sex biases. The gene-wise landscape of X chromosome gene dosage remain ..read more
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Predicting gene expression state and prioritizing putative enhancers using 5hmC signal
BMC » Genome Biology
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2w ago
Like its parent base 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC) is a direct epigenetic modification of cytosines in the context of CpG dinucleotides. 5hmC is the most abundant oxidized form of 5mC ..read more
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Single-cell 3D genome structure reveals distinct human pluripotent states
BMC » Genome Biology
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1M ago
Pluripotent states of embryonic stem cells (ESCs) with distinct transcriptional profiles affect ESC differentiative capacity and therapeutic potential. Although single-cell RNA sequencing has revealed addition ..read more
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Robust differential expression testing for single-cell CRISPR screens at low multiplicity of infection
BMC » Genome Biology
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1M ago
Single-cell CRISPR screens (perturb-seq) link genetic perturbations to phenotypic changes in individual cells. The most fundamental task in perturb-seq analysis is to test for association between a perturbatio ..read more
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