Does It Really Work? How InTraSeq™ Integrates Transcriptomic, Proteomic, & Intracellular Interaction Data
Cell Signaling Technology Blog
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3d ago
The ability to detect intracellular proteins alongside RNA has long been a challenge in single cell research. Analyzing both RNA and proteins simultaneously, however, could reveal new insights into biological processes by enabling the direct measurement of how cell type affects RNA level and protein expression—and, subsequently, their impact on disease mechanisms and therapeutic response ..read more
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Meet the Winners of the 5th Annual Rising Black Scientists Awards
Cell Signaling Technology Blog
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1w ago
We’re thrilled to announce the winners of the 5th annual Rising Black Scientists Awards! Since 2020, CST has been honored to mark the start of Black History Month by highlighting the stories of talented Black scientists at American institutions, as told through their award-winning essays. This year's winners are ..read more
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Deep Proteome Profiling with DIA: 3x the Data, 3x the Insights
Cell Signaling Technology Blog
by Jeffrey Silva, PhD
3w ago
As biotech companies continue to leverage proteomics profiling for critical research such as biomarker discovery, on- & off-target validation, and mechanism of action studies, researchers are more frequently asking: "How can I extract more insights from my precious sample?"  ..read more
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Microglia Activation Antibody Toolkit to Study TREM2 Signaling
Cell Signaling Technology Blog
by Ginny Bain, PhD
2M ago
Selecting antibodies for molecular signaling research in neurodegeneration is a complex and nuanced process, yet it is essential for advancing our understanding of brain function and disease. This blog explores a collaborative project between CST and FUJIFILM Cellular Dynamics, where we used iCell Microglia products alongside a toolkit of key antibodies to characterize signaling events in neurodegenerative diseases. The antibodies we selected provide a valuable, high-content method for verifying the identity and functionality of iPSC-derived microglia (iMGL), particularly in the context of ne ..read more
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Cell Preparation Tips for Live Cell and Intracellular Flow Cytometry
Cell Signaling Technology Blog
by Andrea Tu, PhD
3M ago
Generating accurate flow cytometry data requires more than just specific and sensitive antibodies validated for flow cytometry—it also depends on the right combination of support reagents. When designing your flow experiment, identifying the correct reagents, such as permeabilization buffers, viability dyes, and Fc blockers is important to prevent false positives or negatives and reduce potential cross-reactivity to ensure results you can trust. We connected with our Associate Director of Flow Cytometry, Christopher Manning, to answer some common flow cytometry troubleshooting questions. Rea ..read more
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How Are CST Antibodies Validated for Simple Western? | +500 Abs
Cell Signaling Technology Blog
by Chris LaBreck, PhD
4M ago
Since 2022, Cell Signaling Technology (CST) and Bio-Techne have been working together to bring best-in-class CST antibodies to automated Simple Western™ platforms developed by ProteinSimple (a Bio-Techne brand) like the Jess™ instrument. Now, over 500 CST® antibodies have been validated for Simple Western platforms, driving innovation with unparalleled automation and high-throughput capabilities that empower you to achieve faster, more reliable results ..read more
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Menin-KMT2A Inhibitors: Antibodies to Study KMT2Ar & NPM1-Mutated AML
Cell Signaling Technology Blog
by Homa Rahnamoun, PhD
4M ago
Accounting for about 80% of adult acute leukemias, acute myeloid leukemia (AML) is an aggressive form of blood cancer that is characterized by the uncontrolled proliferation of clonal hematopoietic stem and progenitor cells.1,2 While the disease is initially almost always responsive to chemotherapy and prognosis has vastly improved over the past few decades, the activation of immune-escape mechanisms by leukemic cells and the emergence of chemo-resistant clones cause relapse events to remain rather high.3-5  ..read more
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CST Turns 25: A Quarter Century of Antibodies & Innovations
Cell Signaling Technology Blog
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5M ago
This year, CST turns 25. As we celebrate this significant milestone, we’re also reflecting on how the research reagent industry has changed in the past quarter century, the role CST played in bringing about innovation, and what the future might hold ..read more
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How to Prepare and Deliver a Great Research Presentation
Cell Signaling Technology Blog
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5M ago
After months of running experiments, pouring over data late into the evening, and surviving on whatever snacks drift within arm’s reach, you’re about to present your research for the first time. You’ve memorized every detail, but the thought of facing a live audience still makes your palms sweaty and your knees shake ..read more
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CST Dominates CiteAb's Top Cited RUO Antibody List | Top 3 Antibodies
Cell Signaling Technology Blog
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5M ago
Year after year, CST antibodies are the most cited research reagents used by scientists worldwide. How do we know? CiteAb’s annual list of top research reagents parses over 8.5 million products from 340 companies and more than three million citations to determine the 100 top cited antibodies. The resulting analysis offers a data-driven snapshot of the antibodies (and antibody companies) scientists trust most often with their research projects destined for publication ..read more
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