
Cell Signaling Technology Blog
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Cell Signaling Technology (CST) is a different kind of life sciences company - one founded, owned, and run by active research scientists, with the highest standards of product and service quality, technological innovation, and scientific rigor for over 20 years. We consistently provide fellow scientists around the globe with best-in-class products and services to fuel their quests for discovery.
Cell Signaling Technology Blog
3d ago
The ability to detect intracellular proteins alongside RNA has long been a challenge in single cell research. Analyzing both RNA and proteins simultaneously, however, could reveal new insights into biological processes by enabling the direct measurement of how cell type affects RNA level and protein expression—and, subsequently, their impact on disease mechanisms and therapeutic response ..read more
Cell Signaling Technology Blog
1w ago
We’re thrilled to announce the winners of the 5th annual Rising Black Scientists Awards! Since 2020, CST has been honored to mark the start of Black History Month by highlighting the stories of talented Black scientists at American institutions, as told through their award-winning essays. This year's winners are ..read more
Cell Signaling Technology Blog
3w ago
As biotech companies continue to leverage proteomics profiling for critical research such as biomarker discovery, on- & off-target validation, and mechanism of action studies, researchers are more frequently asking: "How can I extract more insights from my precious sample?"  ..read more
Cell Signaling Technology Blog
2M ago
Selecting antibodies for molecular signaling research in neurodegeneration is a complex and nuanced process, yet it is essential for advancing our understanding of brain function and disease. This blog explores a collaborative project between CST and FUJIFILM Cellular Dynamics, where we used iCell Microglia products alongside a toolkit of key antibodies to characterize signaling events in neurodegenerative diseases. The antibodies we selected provide a valuable, high-content method for verifying the identity and functionality of iPSC-derived microglia (iMGL), particularly in the context of ne ..read more
Cell Signaling Technology Blog
3M ago
Generating accurate flow cytometry data requires more than just specific and sensitive antibodies validated for flow cytometry—it also depends on the right combination of support reagents. When designing your flow experiment, identifying the correct reagents, such as permeabilization buffers, viability dyes, and Fc blockers is important to prevent false positives or negatives and reduce potential cross-reactivity to ensure results you can trust.
We connected with our Associate Director of Flow Cytometry, Christopher Manning, to answer some common flow cytometry troubleshooting questions. Rea ..read more
Cell Signaling Technology Blog
4M ago
Since 2022, Cell Signaling Technology (CST) and Bio-Techne have been working together to bring best-in-class CST antibodies to automated Simple Western™ platforms developed by ProteinSimple (a Bio-Techne brand) like the Jess™ instrument. Now, over 500 CST® antibodies have been validated for Simple Western platforms, driving innovation with unparalleled automation and high-throughput capabilities that empower you to achieve faster, more reliable results ..read more
Cell Signaling Technology Blog
4M ago
Accounting for about 80% of adult acute leukemias, acute myeloid leukemia (AML) is an aggressive form of blood cancer that is characterized by the uncontrolled proliferation of clonal hematopoietic stem and progenitor cells.1,2 While the disease is initially almost always responsive to chemotherapy and prognosis has vastly improved over the past few decades, the activation of immune-escape mechanisms by leukemic cells and the emergence of chemo-resistant clones cause relapse events to remain rather high.3-5  ..read more
Cell Signaling Technology Blog
5M ago
This year, CST turns 25. As we celebrate this significant milestone, we’re also reflecting on how the research reagent industry has changed in the past quarter century, the role CST played in bringing about innovation, and what the future might hold ..read more
Cell Signaling Technology Blog
5M ago
After months of running experiments, pouring over data late into the evening, and surviving on whatever snacks drift within arm’s reach, you’re about to present your research for the first time. You’ve memorized every detail, but the thought of facing a live audience still makes your palms sweaty and your knees shake ..read more
Cell Signaling Technology Blog
5M ago
Year after year, CST antibodies are the most cited research reagents used by scientists worldwide. How do we know? CiteAb’s annual list of top research reagents parses over 8.5 million products from 340 companies and more than three million citations to determine the 100 top cited antibodies. The resulting analysis offers a data-driven snapshot of the antibodies (and antibody companies) scientists trust most often with their research projects destined for publication ..read more