Gene therapies have emerged as a groundbreaking avenue for life-saving treatments in a diverse spectrum of diseases. Harnessing the full potential of this technology is contingent upon scaling of operations to seamlessly transition toward sustainable commercial manufacture. Identifying the optimal cell culture medium is a critical consideration for developers, but choosing the ideal medium format is an equally important part of the process that could significantly impact scalability. Selecting the most suitable format will support streamlined operations and consistent manufacturing processes ..read more

In the fast-paced world of biopharmaceutical manufacturing, ensuring product quality and safety is paramount. One of the critical aspects of maintaining this product integrity is mycoplasma testing. Mycoplasma contamination poses a significant threat to therapeutic efficacy and safety, highlighting the need for robust and sensitive testing solutions. The significance of routine testing, not only as part of in-process testing, is a key element in lot-release procedures. Let’s delve into the significance of mycoplasma testing, explore the features and benefits of PCR-based testing, and how this ..read more

  Rebecca Lim, PhD, is Senior VP of Scientific Affairs at Prescient Therapeutics, a Melbourne-based oncology-focused biotechnology company. Before being recruited to lead R&D at Prescient, Lim spent 15 years as an academic biologist working on cell therapies and regenerative medicine. She was the most highly cited Australian researcher in embryology and developmental biology from 2020-2022, and supported the wet lab testing of early prototypes of the CTS Rotea Counterflow Centrifugation System.    The story of the CTS Rotea Counterflow Centrifugation System for cell therap ..read more

  by Frances Gatta Each year more than 35,000 people in the US are diagnosed with multiple myeloma, making it the second most common blood cancer in the country. One in five of those myeloma patients is African American, and the ratio is expected increase to one in four in the next decade.   Not only is multiple myeloma the most common blood cancer in African Americans, but this patient population also face disparities that aggravate their experiences, outcomes, and survival rates with the disease.   Black patients often get diagnosed later with advanced multiple myel ..read more

Understanding Detachable Dynabeads If you work in the cell therapy field, you are probably familiar with Gibco CTS Dynabeads products. As of 2023, they are used in more than 200 active clinical trials and several commercialized therapies on the market. The next generation of CTS Dynabeads products has just entered the market. The Gibco CTS Detachable Dynabeads CD3/CD28 Kit provides the same one-step isolation and activation as our legacy Dynabeads kits with a major difference—it enables the active release of CTS Dynabeads magnetic beads from the target cells at any point in the process. The C ..read more

The benefits of commercial testing kits Choosing the right tools for assessing safety and quality, such as residual DNA, in therapeutic products to enable compliance with regulatory guidelines is critical for manufacturers. Using commercially available kits is a wise choice as they help leverage standardized and tested components to ensure data accuracy and can help with regulatory compliance. As biologic therapeutic development advances and becomes more complex, it is crucial to ensure product safety, quality, and compliance with regulatory agencies without increasing workflow time. Residual ..read more

What is Gibco AGT dry media format? Advanced Granulation Technology (AGT) is a well-established and scalable dry media format that combines complex dry and liquid media formulations into a dry, single-component, granulated medium. The technology also simplifies the handling and reconstitution of media and feeds in production while streamlining raw materials quality control. AGT Gibco cell culture products help users overcome challenges associated with dry media preparation, such as multiple hydration steps, pH adjustments, long hydration times, inconsistent batches, and clumping and floating o ..read more

Since 2017, the Thermo Fisher Scientific™ Aspire Member Program™ has rewarded more than 60,000 life scientists for their research contributions to the field with Thermo Fisher products.  Learn more about some of our current program members in this Q+A where they share what they enjoy about being an Aspire member, how they have put free product to practical use in research, and their opinions on the best science-branded rewards through the years.   Join the free Aspire Member Program at thermofisher.com/aspire* »      Rajiv Rangan Member Since 2022 How has your ex ..read more

Fluorescent multiplexing for more data from your sample with iBright. Multiplexing can capture up to four proteins in a single blot for more meaningful and representative experiments, a must for western blot publication.   For today’s top journals, total protein normalization and high-quality images are the keys to western blot publication    Table of Contents Introduction Overview of Normalization Housekeeping Proteins vs. Total Protein Normalization Journal-Specific Western Blot Publication Guidelines Nature Science Cell Press Journal of Biological Chemistry Elsevier Wiley M ..read more

  As the global scientific community celebrates the 70th anniversary of the discovery of DNA, 2023 also marks the anniversary of the powerful technology that revolutionized PCR 20 years ago. In 2003, the introduction of Thermo Scientific™ Phusion™ High-Fidelity DNA Polymerase enabled high-performance PCR and ushered in an era of continuous advances in fusion protein technology designed for superior fidelity of DNA replication.    Each Phusion product introduction—from Thermo Scientific™ Phusion™ Hot-Start Polymerase to the latest Thermo Scientific™ Phusion™ Plus DNA Polyme ..read more