Sustained release delivery of favipiravir through statistically optimized, chemically cross-linked, pH-sensitive, swellable hydrogel
BMC Pharmacology and Toxicology
by Arooj Khan, Muhammad Zaman, Muhammad Ahsan Waqar, Asif Mahmood, Talal Shaheer, Rai Muhammad Sarfraz, Kanwal Shahzadi, Azmat Ali Khan, Amer M. Alanazi, Milton Kumar Kundu, Md Rabiul Islam, Athanasios Alexiou and Marios Papadakis
3d ago
In the current work, favipiravir (an antiviral drug) loaded pH-responsive polymeric hydrogels were developed by the free redical polymerization technique. Box-Behnken design method via Design Expert version 11 ..read more
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Blocking group 2 innate lymphoid cell activation and macrophage M2 polarization: potential therapeutic mechanisms in ovalbumin-induced allergic asthma by calycosin
BMC Pharmacology and Toxicology
by Chunyan Tian, Qi Liu, Xiaoyu Zhang and Zhuying Li
1w ago
Calycosin, a flavonoid compound extracted from Astragalus membranaceus, has shown anti-asthma benefits in house dust mite-induced asthma. Recent studies have suggested that innate-type cells, including group 2 in ..read more
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Determination of drug-related problems according to PAIR criteria in dialysis patients: a cross-sectional study in tertiary care hospital
BMC Pharmacology and Toxicology
by Aysel Pehlivanli, Sayeste Akkan Eren, Sule Sengul, Bilgen Basgut, Sehsuvar Erturk and A. Tanju Ozcelikay
1w ago
Dialysis patients are at high risk for drug-related problems (DRPs), which have significant consequences for their morbidity, mortality, and quality of life. Improved clinical outcomes can be achieved by preve ..read more
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Dapagliflozin promotes white adipose tissue browning though regulating angiogenesis in high fat induced obese mice
BMC Pharmacology and Toxicology
by Lin Xiang, Min Liu, Guangda Xiang, Ling Yue, Junxia Zhang, Xiaoli Xu and Jing Dong
1M ago
Browning of white adipose tissue (WAT) is become an appealing target for therapeutics in the treatment of obesity and related metabolic diseases. Dapagliflozin is widely used in the treatment of type 2 diabete ..read more
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Risk of CKD among patients with DM taking diuretics or SGLT2i: a retrospective cohort study in Taiwan
BMC Pharmacology and Toxicology
by Han-Jie Lin, Pin-Yang Shih, Stella Chin-Shaw Tsai, Wu-Lung Chuang, Tsai-Ling Hsieh, Heng-Jun Lin, Teng-Shun Yu, Fuu-Jen Tsai, Chiu-Ying Chen and Kuang-Hsi Chang
2M ago
This study aimed to evaluate the long-term risk of CKD and renal function declines using a combination of diuretics and SGLT2i ..read more
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Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment
BMC Pharmacology and Toxicology
by Tove Selvin, Malin Berglund, Lena Lenhammar, Magnus Lindskog, Malin Jarvius, Rolf Larsson, Peter Nygren, Mårten Fryknäs and Claes R Andersson
2M ago
It has become evident in the field of oncology that the outcome of medical treatment is influenced by the combined effect exerted on both cancer- and immune cells. Therefore, we evaluated potential immunologic ..read more
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Iron overload induced submandibular glands toxicity in gamma irradiated rats with possible mitigation by hesperidin and rutin
BMC Pharmacology and Toxicology
by Salwa Farid Ahmed, Eman M. F. El-Maghraby, Maha M. Rashad and Dina W. Bashir
2M ago
Radiation triggers salivary gland damage and excess iron accumulates in tissues induces cell injury. Flavonoids are found in some fruits and are utilized as potent antioxidants and radioprotective agents. This ..read more
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Preparation and evaluation of transdermal permeation of Huperzine A ethosomes gel in vitro
BMC Pharmacology and Toxicology
by Jiyu Wu, Renai Xu, Xiaowei Xu, Shiyuan Ye and Aifang Huang
2M ago
This study aimed to design and evaluate the transdermal permeation of Huperzine A ethosomes gel in vitro. Huperzine A ethosomes were prepared using the injection method, and their physical and chemical propert ..read more
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The effect of oral supplementation of Paricalcitol on C-reactive protein levels in chronic kidney disease patients: GRADE-assessed systematic review and dose-response meta-analysis of data from randomized controlled trials
BMC Pharmacology and Toxicology
by Seyyed Mostafa Arabi, Mostafa Shahraki-Jazinaki, Mahla Chambari, Leila Sadat Bahrami, Sara Sabeti, Mohammaed Ibrahim Mohaildeen Gubari, Basil D. Roufogalis and Amirhossein Sahebkar
2M ago
Previous studies investigating the effect of oral supplementation of paricalcitol on reactive protein levels in chronic kidney disease (CKD) patients reported inconsistent findings. In this systematic review a ..read more
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Pharmacovigilance study of BCR-ABL1 tyrosine kinase inhibitors: a safety analysis of the FDA adverse event reporting system
BMC Pharmacology and Toxicology
by Dehua Zhao, Xiaoqing Long and Jisheng Wang
2M ago
With the increased use of BCR-ABL1 tyrosine kinase inhibitors (TKIs) in cancer patients, adverse events (AEs) have garnered considerable interest. We conducted this pharmacovigilance study to evaluate the AEs ..read more
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