IRVINE, Calif. — October 24, 2023 — Irvine-based Biogennix, an osteobiologics company that develops, manufactures, and distributes proprietary bone graft products used for bone fusion procedures, today announced the launch of its new OsteoSPAN Fiber Matrix. Consisting of 100% demineralized cortical fibers, OsteoSPAN Fiber Matrix has been engineered for optimized handling, while providing verified osteoinductive potential and an osteoconductive scaffold that supports cellular bone formation and stimulates fusion. OsteoSPAN Fiber Matrix is also processed to provide rapid, consistent hydration ..read more

Download As bone graft materials and surgical techniques have evolved, there has been increasing interest in the use of stem cells for bone regeneration. Stem cells are unique cells in our bodies that can morph into a variety of different cells, including bone cells, and can improve the bone healing response.  Stem cells or other tissues used in bone grafting surgery come from two sources:  Autologous Tissue (autograft) – stem cells or bone harvested from the patient being treated, or  Allogeneic Tissue (allograft) – stem cells or bone taken from a deceased donor.  ..read more

Download Iridescent staining of mesenchymal stem cells from tissue culture (main image) and more differentiated cells (top right1) showing stained nuclei (blue), microtubules (green), and actin filaments (red). The use of stem cells in bone grafting applications continues to grow in popularity. This is due in part to aging patient populations that require more advanced materials for successful surgical outcomes. In parallel, surgeons are seeking more advanced technologies to treat these patients.   Stem cells are unique because they can be stimulated to change, or “differen ..read more

Download Bone Graft Resorption: An Introduction As covered in a previous blog about bone resorption, the processes of bone modeling and bone remodeling can be described as a coordinated interaction between stem cells, osteocytes, osteoblasts, and osteoclasts. Whether bone is modeling or remodeling depends on the balance between the resorption of existing bone and the formation of new bone.   The same cells involved in these processes also play a role in the healing response to bone graft materials. After a bone graft material is implanted in a patient during surgery, the bon ..read more

Download As bone graft materials and surgical techniques have evolved, there has been increasing interest in the use of stem cells for bone regeneration. Stem cells are unique cells in our bodies that can morph into a variety of different cells, including bone cells, and can improve the bone healing response.  Stem cells or other tissues used in bone grafting surgery come from two sources:  Autologous Tissue (autograft) – stem cells or bone harvested from the patient being treated, or  Allogeneic Tissue (allograft) – stem cells or bone taken from a deceased donor.  I ..read more

Download Iridescent staining of mesenchymal stem cells from tissue culture (main image) and more differentiated cells (top right1) showing stained nuclei (blue), microtubules (green), and actin filaments (red). The use of stem cells in bone grafting applications continues to grow in popularity. This is due in part to aging patient populations that require more advanced materials for successful surgical outcomes. In parallel, surgeons are seeking more advanced technologies to treat these patients.   Stem cells are unique because they can be stimulated to change, or “differentiate ..read more

IRVINE, Calif.–(BUSINESS WIRE)–Irvine-based Biogennix, a market leader in advanced bone regeneration technology, announced today that its DirectCell® Advanced Bone Grafting System has been used in more than 1000 cases as of this quarter. “It’s been rewarding to see our DirectCell System be so well received in the surgeon community” Tweet this The DirectCell System includes an advanced synthetic bone graft material with properties that enhance cellular bone formation, along with novel instrumentation engineered to harvest high concentrations of patient stem cells. This provid ..read more

Download Bone Graft Resorption: An Introduction As covered in a previous blog about bone resorption, the processes of bone modeling and bone remodeling can be described as a coordinated interaction between stem cells, osteocytes, osteoblasts, and osteoclasts. Whether bone is modeling or remodeling depends on the balance between the resorption of existing bone and the formation of new bone.   The same cells involved in these processes also play a role in the healing response to bone graft materials. After a bone graft material is implanted in a patient during surgery, the bone for ..read more

IRVINE, Calif.–(BUSINESS WIRE)–Irvine-based Biogennix, a market leader in advanced bone regeneration technology, announced today that the second quarter of 2022 was the best in company history. The company also announced that the first half of 2022 (encompassing the first and second quarters of 2022) was the best performing six-month period for the company to date. “Thanks to a positive reception for our more recent offerings like the DirectCell Advanced Bone Grafting System and Agilon advanced synthetic bone graft products, in addition to continued strong sales of our leg ..read more

Download Earlier blog posts have explained the processes of bone modeling and bone remodeling. Whether bone is modeling or remodeling depends on the balance of bone formation and bone resorption.  This blog will describe these cellular processes in detail and provide background for a more detailed understanding of how bone formation and bone resorption impact bone graft materials.   Bone Remodeling vs. Bone Modeling  When using bone graft materials, it is important to understand how bone remodeling and bone modeling work, because these two processes impact how the body resp ..read more