The director’s cut: how CAG repeats change the editing of genetic messages
HDBuzz
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11h ago
Scientists in Massachusetts have recently advanced our understanding of how repetitive sequences in DNA can disrupt the creation and editing of genetic messenger molecules in cells, and how this could lead to the production of harmful proteins ..read more
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Understanding expansions at the single cell level
HDBuzz
by
3w ago
Scientists have looked at CAG expansions in brains from people with HD to see which cells are affected ..read more
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Huntington's Disease Therapeutics Conference 2024 - Day 3
HDBuzz
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1M ago
Making babies: HDBuzz's feature article - updated for 2024 - on fertility technologies that can help at-risk people to have HD-free children ..read more
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CRISPR-based drugs: one giant leap for mankind
HDBuzz
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1M ago
Dr Rachel Harding, Dr Sarah Hernandez, and Dr Leora Fox ..read more
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Huntington's Disease Therapeutics Conference 2024 - Day 1
HDBuzz
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1M ago
Dr Rachel Harding, Dr Sarah Hernandez, and Dr Leora Fox ..read more
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Making babies: having a family, the HD way
HDBuzz
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2M ago
Making babies: HDBuzz's feature article - updated for 2024 - on fertility technologies that can help at-risk people to have HD-free children ..read more
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Steady progress from uniQure - promising data to end the year
HDBuzz
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3M ago
uniQure ushered in the end of the year by releasing some promising data from their huntingtin-lowering gene therapy trials ..read more
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Putting it in print: GENERATION HD1 study results published
HDBuzz
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4M ago
Data from GENERATION HD1, the Phase 3 clinical trial testing the huntingtin-lowering drug tominersen, have just been published in a scientific journal. The trial ended a while back, so why is this an important milestone, and what’s next ..read more
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Regulating repetition: Gaining control of CAG repeats could slow progression of Huntington’s disease
HDBuzz
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4M ago
Many diseases are caused by repetitive DNA sequences. Understanding the regulation of those repetitive sequences may hold the key for unlocking therapeutics for Huntington’s disease. A team from Toronto has just advanced our understanding ..read more
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Beyond huntingtin lowering: out-of-the-box approaches for the treatment of HD
HDBuzz
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4M ago
The HD pipeline is rich and varied. Let's talk about some out-of-the-box approaches for developing drugs for HD that don't involve huntingtin lowering ..read more
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