Genetics and Genomics in Cardiovascular Health Risk: It’s Complicated
Association for the Advancement of Restorative Medicine
by admin
4M ago
Genetics focuses on single genes or sequence variations in a small group of genes whose presence is associated with an increased risk of developing a particular health disorder. For example, familial hypercholesterolemia, which is a risk factor for developing coronary artery disease, is associated with the presence of sequence variations in a distinct group of genes including LDLR (which encodes for the low-density lipoprotein receptor) or APOB (which encodes for apolipoprotein B). Information transmitted through DNA is obviously important, but it is interesting to reflect that family lineage ..read more
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The Role of Viral Infection in Heart Failure
Association for the Advancement of Restorative Medicine
by admin
4M ago
The myocardium is vulnerable to injury from ischemia, hemodynamic overload, or pathogens. Irrespective of the cause, myocardial damage will activate innate and adaptive immune responses. The production of pro-inflammatory cytokines triggered by the innate immune response is initially cytoprotective. However, if the inflammatory response becomes dysregulated, chronic exposure of the myocardium to the ongoing production of pro-inflammatory cytokines can lead to left ventricular dysfunction (LVD). LVD is associated with many changes in heart structure and function, including negative inotropic ef ..read more
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Effects of a Nutritional Supplement Combination on Blood Glucose Measurements in Adults with Type 2 Diabetes
Association for the Advancement of Restorative Medicine
by admin
5M ago
Abstract We studied the effect of a dietary supplement on blood glucose. This prospective, single-arm, unblinded clinical interventional study investigated the impact of a nutritional supplement combination on fasting glucose and glycated hemoglobin (A1c) levels, which were measured before and after the intervention. The supplement, which consisted of organic mulberry leaf extract, LactoSpore probiotics, and Fenumannan prebiotic, was given to adult (age ≥21 years) prediabetics and adults with type 2 diabetes (A1c >5.60 mg/dL). The study protocol comprised six phases including initial and fi ..read more
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Expediting COVID-19 Recovery with an Orthomolecular Approach: Two Case Reports
Association for the Advancement of Restorative Medicine
by admin
6M ago
Abstract These case reports discuss two middle-aged patients with confirmed symptomatic COVID-19 infection that improved swiftly upon receiving orthomolecular oral and intravenous therapy. The intravenous solution provided minerals like magnesium, as well as vitamin C and B complex vitamins, among others. The patients also started iodine-based nasopharyngeal decontamination spray and oral supplements, including substantial doses of vitamins C, B complex, and D, as well as magnesium, zinc, quercetin, melatonin, and omega-3. In addition, two types of biological response modifiers, palmitoylethan ..read more
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TUDCA and Neurodegeneration
Association for the Advancement of Restorative Medicine
by admin
8M ago
A Protective Role for Bile Acids in Neurodegenerative Conditions In addition to aiding lipid absorption in the intestines and regulating cholesterol homeostasis, bile acids have hormone-like signaling activity that exerts far-reaching influence on an array of biological processes, including those that affect neurological health.1 Cholesterol and related lipid molecules are critical components of myelin, and neuronal and glial cell membranes,2,3 but the neurological impact of bile acids extends even further than that. Research continues to highlight the crucial role the gut microbiome-brain axi ..read more
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Fisetin and Lung Health
Association for the Advancement of Restorative Medicine
by admin
9M ago
Epidemiological studies have noted for some time that a relationship exists between lung function and diet. A meta-analysis published in 2015 found that an unhealthy, western-style diet was associated with increased risk for chronic obstructive pulmonary disease (COPD). Conversely, healthy dietary patterns were associated with reduced risk for COPD. These findings suggested that diet could have a protective impact on COPD pathophysiology, most likely through modulating inflammatory pathways and oxidative stress, which are two factors implicated in COPD onset.1 Higher dietary intake of flavonoi ..read more
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Senolytic Therapy and Cancer
Association for the Advancement of Restorative Medicine
by admin
9M ago
It is well known that chemotherapy and radiotherapy accelerate the aging process in cancer survivors. In fact, the incidence of age-associated diseases in cancer survivors is comparable to rates in the elderly.1 Anti-cancer agents damage DNA in both tumor cells and healthy tissue. This onslaught of DNA damage (known as genotoxic stress) overwhelms cellular repair capacity and activates a complex cascade of signaling pathways that can drive damaged cells toward apoptosis or senescence. Apoptosis and cellular senescence are failsafe mechanisms designed to limit the propagation of a damaged genom ..read more
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A Novel Role for Senolytic Therapies
Association for the Advancement of Restorative Medicine
by admin
10M ago
Evidence from experimental studies, as well as the observable increased risk of mortality and morbidity associated with infections in the elderly,1demonstrate that immune competence declines with age. A cardinal characteristic of immunosenescence and age-related cellular senescence in general, is a shift to the senescence-associated secretory phenotype (SASP). Senescent cells are metabolically active but resistant to apoptosis. They produce mediators that are largely pro-inflammatory, complement-activating (an aspect of innate immunity), pro-coagulatory, and detrimental to the extracellular ma ..read more
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Berberine in Cardiovascular and Metabolic Health
Association for the Advancement of Restorative Medicine
by admin
10M ago
Berberine is a highly versatile botanical with extensive physiological activity resulting from its ability to interact with numerous enzyme systems, receptor sites, and cell signaling pathways. Both pre-clinical and clinical studies continue to shed light on berberine's therapeutic potential, corroborating many of its traditional uses. Berberine has antioxidant and anti-inflammatory effects and can help regulate certain metabolic processes. For example, studies show that berberine may improve insulin resistance, support insulin secretion, inhibit lipogenesis, and rebalance the gut microbiome ..read more
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CBD as a Physiological Modulator for Cancer
Association for the Advancement of Restorative Medicine
by admin
11M ago
Abstract The current standard-of-care treatment regimens for cancer frequently have serious and irreversible adverse effects. Ideally, therapeutic modalities should help control symptoms and improve the patient's quality of life while causing minimal or no toxic effects. In this regard, it is worth examining cannabidiol (CBD) for its potential anticancer properties. CBD may possess antitumor activity through several mechanisms, including regulating reactive oxygen species, endoplasmic reticulum stress, inflammation, and immune modulation. In addition, pre-clinical studies indicate that CBD is ..read more
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