One PK table to rule them all One table to find them One table to bring them all And in the darkness blind them… …with awesome antibiotic PK facts you can use to bedazzle your friends and enemies alike! Prep notes here.  Support the show Questions, comments, suggestions to idiotspodcasting@gmail.com or on X/Threads @IDiots_pod Prep notes for completed episodes can be found here (Not all episodes have prep notes). If you are enjoying the podcast please leave a review on your preferred podcast app! Feel like giving back? Donations of caffeine gratefully received! https://www.buymeacoff ..read more

The last Pharmacokinetics episode had finally been …Excreted!    This episode  covers the ‘drug out’ bit of pharmacokinetics, including things such as:    -What is clearance?  -how to calculate half life  and  -doesn’t everything leave through the kidneys anyway? (That is sort of true, also shut up).    Check out our prep notes (including for this episode) here.  Support the show Questions, comments, suggestions to idiotspodcasting@gmail.com or on X/Threads @IDiots_pod Prep notes for completed episodes can be found here (Not all episodes ..read more

It's the second Pharmacokinetics episode you never knew you wanted! Let’s talk about how antibiotics are distributed around the body once absorbed, using the examples of Amoxicillin and CallumShutUpicillin (listen to episode for clarification). What exactly is the volume of distribution? Want a handy reference for the plasma protein binding of various antimicrobials? Then this is the episode for you! Check out our prep notes (including for this episode) here.  Support the show Questions, comments, suggestions to idiotspodcasting@gmail.com or on X/Threads @IDiots_pod Prep notes for comp ..read more

It's the Pharmacokinetics episode you never knew you wanted! Callum didn't know either, but never mind that let's talk about how antibiotics are absorbed, and how we can use that to improve our use of them in clinical practice. Want ammunition for that oral switch? Got someone who's doubting oral antibiotics' effectiveness? Then this is the episode for you! Check out our prep notes (including for this episode) here.  Support the show Questions, comments, suggestions to idiotspodcasting@gmail.com or on X/Threads @IDiots_pod Prep notes for completed episodes can be found here (Not all epi ..read more

In this final episode of the Nobbling the Nonfermentors mini-series, Jame and Callum discuss the (mostly historical) pathogen Burkholderia mallei, causative agent of Glanders.  We did it. We got to the end.  Nonfermentors... Nobbled.  Support the show Questions, comments, suggestions to idiotspodcasting@gmail.com or on X/Threads @IDiots_pod Prep notes for completed episodes can be found here (Not all episodes have prep notes). If you are enjoying the podcast please leave a review on your preferred podcast app! Feel like giving back? Donations of caffeine gratefully received ..read more

Post-publication, Callum and Jame give a little extra information on the SABATO trial in its final form compared to it's pre-publication state. Final article here: Efficacy and safety of an early oral switch in low-risk Staphylococcus aureus bloodstream infection (SABATO): an international, open-label, parallel-group, randomised, controlled, non-inferiority trial, Kaasch, Achim J Valiente, Adoración et al. Lancet Infect Dis. 2024 Jan 17:S1473-3099(23)00756-9. PMID: 38244557. https://doi.org/10.1016/S1473-3099(23)00756-9 Support the show Questions, comments, suggestions to idiotspodcasting@gma ..read more

JOURNAL CLUB, YO, IT’S A SABATO!!! Join Jame and Callum as we travel back in time to when we recorded this deep dive into the SABATO trial pre-print, now peer-reviewed and published in the Lancet ID! In the next episode we'll give a little update as to how the final article differs from the preprint (not much). We also talked about in our FIS Highlights Episode 3. We loved this trial and we hope you’ll all give it a read, it’s well worth it! Article here: Efficacy and safety of an early oral switch in low-risk Staphylococcus aureus bloodstream infection (SABATO): an international, open-la ..read more

In this penultimate episode in the Nobbling the Nonfermentors mini-series, Jame and Callum discuss the regionally important neglected tropical disease Melioidosis, caused by Burkholderia pseudomallei. This episode was based disproportionately on the following article, and we extend our thanks to the authors for thoughfully publishing it so close to us wanting to do a podcast episode on Melioid! Meumann, E.M., Limmathurotsakul, D., Dunachie, S.J. et al. Burkholderia pseudomallei and melioidosis. Nat Rev Microbiol (2023). https://www.melioidosis.info/ Link to prep notes here. Support the sho ..read more

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How do you think about antibiotics? This Christmas we give the best gift of all: no puns in an episode. Join Jame and Callum as they talk about a method for thinking about and explaining antibiotics. Here are the show notes for this episode: https://idiots.notion.site/69-Choosing-an-antimicrobial-4e7446a91ff6413aa14924a2ba905ffa  Support the show Questions, comments, suggestions to idiotspodcasting@gmail.com or on X/Threads @IDiots_pod Prep notes for completed episodes can be found here (Not all episodes have prep notes). If you are enjoying the podcast please leave a review on your p ..read more