CCL2 gene ID’d as common biomarker in SSc, IPF in new study
Scleroderma News
by Margarida Maia, PhD
1w ago
The CCL2 gene, which codes for a signaling protein of the same name, is “a common characteristic gene” of both systemic sclerosis (SSc) and idiopathic pulmonary fibrosis (IPF), a serious complication of SSc that causes the lungs to become inflamed and scarred, according to a study by researchers in China “We identified CCL2 as a common biomarker […] The post CCL2 gene ID’d as common biomarker in SSc, IPF in new study appeared first on Scleroderma News ..read more
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Autotaxin protein found at higher levels in women with SSc-ILD
Scleroderma News
by Andrea Lobo, PhD
1w ago
Autotaxin, a protein involved in wound healing and scarring, or fibrosis, was found at higher levels in women with systemic sclerosis-associated interstitial lung disease (SSc-ILD) than in men with the condition, per a new U.S. study. According to the researchers, “this study is the first to report sex-specific … protein differences in patients with SSc-ILD.” […] The post Autotaxin protein found at higher levels in women with SSc-ILD appeared first on Scleroderma News ..read more
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SSc patients with scleroderma renal crisis have high PIGF levels
Scleroderma News
by Katherine Poinsatte
2w ago
Scleroderma (SSc) patients who’ve had a scleroderma renal crisis, a life-threatening complication of SSc, have higher levels of placental growth factor (PIGF), protein that stimulates blood vessel growth, in their blood than those who haven’t had one, a study in France shows. Among French patients who’d had a scleroderma renal crisis, higher PIGF levels were […] The post SSc patients with scleroderma renal crisis have high PIGF levels appeared first on Scleroderma News ..read more
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Autoantibodies tied to mortality, organ involvement in scleroderma
Scleroderma News
by Katherine Poinsatte
1M ago
Organ involvement and outcomes among people with systemic sclerosis (SSc) are strongly associated with seven specific self-reactive antibodies, a French study has found. Among their findings, researchers identified antibodies that targets RNA polymerase III as strongly associated with scleroderma renal crisis, a rare and severe manifestation of SSc marked by high blood pressure, and kidney […] The post Autoantibodies tied to mortality, organ involvement in scleroderma appeared first on Scleroderma News ..read more
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Phase 2 trial tests tibulizumab in adults with diffuse SSc
Scleroderma News
by Andrea Lobo, PhD
1M ago
Zura Bio has launched a Phase 2 trial to evaluate the safety and efficacy of tibulizumab, its experimental dual pathway antibody to treat systemic sclerosis (SSc). The TibuSURE trial is expected to enroll as many as 80 adults with early diffuse cutaneous SSc. They will receive tibulizumab or a placebo for 24 weeks (about six […] The post Phase 2 trial tests tibulizumab in adults with diffuse SSc appeared first on Scleroderma News ..read more
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Skin thickness regression linked to better lung health in dcSSc
Scleroderma News
by Esteban Dominguez Cerezo, MS
2M ago
Reduction in skin thickness may indicate better lung health and survival outcomes in people with diffuse cutaneous systemic sclerosis (dcSSc), according to an analysis of patients from the European Scleroderma Trials and Research (EUSTAR) registry. “Skin regressive patients have a lower probability of lung progression, better survival,” the investigators wrote. Skin improvement may be used as […] The post Skin thickness regression linked to better lung health in dcSSc appeared first on Scleroderma News ..read more
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ILD may appear years after other symptoms of scleroderma: Study
Scleroderma News
by Esteban Dominguez Cerezo, MS
2M ago
Interstitial lung disease (ILD), a condition in which scarring damages lung tissue and makes breathing difficult, may appear several years after other symptoms of scleroderma (SSc) start, a study reported. Late-onset ILD in SSc was similar lung in severity and progression to the early-onset presentation. “Surveillance for incident ILD should continue even in patients with […] The post ILD may appear years after other symptoms of scleroderma: Study appeared first on Scleroderma News ..read more
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Fatigue levels in scleroderma tied to lifestyle, disease factors: Study
Scleroderma News
by Andrea Lobo, PhD
2M ago
Fatigue levels in people with scleroderma, also known as systemic sclerosis or SSc, are tied to several social, demographic, lifestyle, and disease-related factors, according to a study by a multinational team of researchers. Smoking, higher body mass index (BMI) — a measure of body fat based on height and weight — pain, gastrointestinal involvement, and […] The post Fatigue levels in scleroderma tied to lifestyle, disease factors: Study appeared first on Scleroderma News ..read more
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Chest CT scan before transplant may predict survival after: Study
Scleroderma News
by Steve Bryson, PhD
2M ago
A chest CT scan taken before a lung transplant can help predict survival after the transplant in people with systemic sclerosis (SSc), a new U.S. study suggests. Muscle mass, bone density, and the volume of the heart and blood vessels were among the “novel image features” of the pretransplant CT that best predicted a patient’s […] The post Chest CT scan before transplant may predict survival after: Study appeared first on Scleroderma News ..read more
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Soquelitinib shows promise in mice as treatment for lung disease in SSc
Scleroderma News
by Steve Bryson, PhD
2M ago
Soquelitinib, Corvus Pharmaceuticals’ immune-modulating investigational oral treatment for autoimmune diseases and certain cancers, reduced the signs and symptoms of lung disease caused by systemic sclerosis (SSc), according to new preclinical data. Designed to selectively block ITK, an enzyme predominantly found in immune T-cells, soquelitinib suppresses Th2 cells — a type of immune helper T-cells whose […] The post Soquelitinib shows promise in mice as treatment for lung disease in SSc appeared first on Scleroderma News ..read more
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