Cardiovascular outcomes in patients with homozygous familial hypercholesterolaemia on lipoprotein apheresis initiated during childhood: long-term follow-up of an international cohort from two registries
The Lancet » Child & Adolescent Health
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1M ago
Among patients with HoFH, lipoprotein apheresis initiated during childhood and adolescence is associated with reduced long-term risk of atherosclerotic cardiovascular disease and death, and clear benefits of early initiation of high-frequency treatment on reducing plasma cholesterol were found. Consensus recommendations are now needed to guide more widespread and timely use of lipoprotein apheresis for children with HoFH, and research is required to further optimise treatment and ensure benefits of early and aggressive treatment delivery are balanced against effects on quality of life ..read more
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Monitoring change from residential housing care to family-based care for children
The Lancet » Child & Adolescent Health
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1M ago
In January, 2024, UNICEF announced that across European and central Asian countries, family-based care has become the dominant type of alternative care for children without available parents. gives promising indication that deinstitutionalisation policies are closing residential housing facilities and that increasingly, with the regrettable exception of children with disabilities, children are less likely to find themselves in residential care. On this basis, UNICEF calls for continued investment in family-based arrangements and deinstitutionalisation ..read more
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Adolescent girls at the intersection of poverty, migration, and gender
The Lancet » Child & Adolescent Health
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1M ago
The International Labor Organization estimates that, globally, 9·6% of children aged 5–17 years are child labourers, and that sub-Saharan Africa has the highest rate of child labour (24%) compared with other regions in the world. The International Labor Organization draws attention to migrant child labourers as an under-reported and highly vulnerable group, a substantial proportion of whom are girls with no formal education. Unaccompanied child migration and child labour are intricately related, as many unaccompanied migrant children need to work to financially survive ..read more
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The value of registries for rare and severe adverse events in paediatrics
The Lancet » Child & Adolescent Health
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2M ago
Medical registries have been defined as “a database of identifiable persons containing a clearly defined set of health and demographic data collected for a specific public health purpose”. The first instance of such registries is widely reported to be the National Leprosy Registry of Norway in 1856. Modern registries have proliferated widely since the first commercial implementations of relational databases in the late 1970s and 1980s on the basis of theoretical work by Codd. That expansion was further facilitated by the development of the World Wide Web in the 1990s, increasing the ease of re ..read more
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Youth engagement at The Lancet Child & Adolescent Health
The Lancet » Child & Adolescent Health
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2M ago
In 2021, we made a commitment to expand our youth engagement at The Lancet Child & Adolescent Health and launched our inaugural Youth Advisory Panel , with eight youth advisors aged 16–24 years from diverse backgrounds globally. The Youth Advisory Panel sits alongside our International Advisory Board and has been influential in the journal's work in the past 3 years. The editorial team has valued their thoughtful feedback on content and suggestions for topics, and enjoyed discussing issues such as gender equity, climate change, a career in research, and the impact of the COVID-19 pandemic ..read more
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Rare and severe adverse events in children with inflammatory bowel disease: analysis of data from the PIBD-SETQuality Safety Registry
The Lancet » Child & Adolescent Health
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2M ago
The PIBD-SETQuality Safety Registry enabled us to identify incidence rates of rare and severe adverse events in children with IBD. Our findings can guide physicians and enhance awareness of the incidence of adverse events in children with IBD that are considered to be rare ..read more
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Achievement goals and adolescent depression: implications for school-based interventions
The Lancet » Child & Adolescent Health
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3M ago
Schools have long been recognised as an opportune setting to promote mental health and wellbeing because they provide wide reach and broad access to programmes aiming to prevent mental health issues. Traditionally, school-based prevention programmes have grappled with low uptake and limited efficacy when directly targeting psychological factors through interventions such as cognitive behavioural therapy Suggestions to develop and deliver indirect prevention programmes which target modifiable risk factors, such as sleep health, nutrition, physical activity, and alcohol use, have also showed lim ..read more
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The association between academic achievement goals and adolescent depressive symptoms: a prospective cohort study in Australia
The Lancet » Child & Adolescent Health
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3M ago
Depressive symptoms in adolescents were associated with their achievement goals, which could be targetable risk factors for future trials to investigate whether school-based interventions that aim to enhance factors consistent with mastery goals (ie, learning skills and understanding the subject, rather than assessing competence in comparison to peers) could prevent depression in adolescents ..read more
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Tackling the threat of antimicrobial resistance in neonates and children: outcomes from the first WHO-convened Paediatric Drug Optimisation exercise for antibiotics
The Lancet » Child & Adolescent Health
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3M ago
Children and neonates are highly vulnerable to the impact of antimicrobial resistance. Substantial barriers are faced in relation to research and development of antibacterial agents for use in neonates, children, and adolescents aged yonger than 19 years, and focusing finite resources on the most appropriate agents for development and paediatric optimisation is urgently needed. In November and December, 2022, following the successes of previous similar disease-focused exercises, WHO convened the first Paediatric Drug Optimisation (PADO) exercise for antibiotics, aiming to provide a shortlist o ..read more
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Diagnostic test accuracy of procalcitonin and C-reactive protein for predicting invasive and serious bacterial infections in young febrile infants: a systematic review and meta-analysis
The Lancet » Child & Adolescent Health
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4M ago
Within a large cohort of febrile infants, a procalcitonin cutoff of 0·5 ng/mL had a superior pAUC value to a C-reactive protein cutoff of 20 mg/L for identifying invasive bacterial infections. In settings without access to procalcitonin, C-reactive protein should therefore be used cautiously for the identification of invasive bacterial infections, and a cutoff value below 20 mg/L should be considered. C-reactive protein and procalcitonin showed similar test accuracy for the identification of serious bacterial infection with internationally recognised cutoff values ..read more
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