Microaxial Flow Pump for STEMI and Cardiogenic Shock
The New England Journal of Medicine
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1w ago
In a randomized trial involving patients with STEMI and cardiogenic shock, mortality at 6 months was lower with mechanical circulatory support with a microaxial flow pump than with standard care alone ..read more
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Empagliflozin after Acute Myocardial Infarction
The New England Journal of Medicine
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1w ago
Among patients hospitalized for acute myocardial infarction and at risk for heart failure, empagliflozin did not lead to a significantly lower risk of a first heart-failure hospitalization or death from any cause than placebo ..read more
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Minimally Invasive Removal of Cerebral Hematoma
The New England Journal of Medicine
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1w ago
In a trial of minimally invasive cerebral hematoma removal within 24 hours after onset of hemorrhage, functional outcomes were better with surgery than with medical treatment, particularly among patients with lobar hemorrhages ..read more
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Ribociclib + Endocrine Therapy in Early Breast Cancer
The New England Journal of Medicine
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2w ago
In patients with stage II or III early breast cancer, the addition of ribociclib to adjuvant hormonal therapy resulted in a significant improvement in 3-year invasive disease–free survival ..read more
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Selpercatinib and Pseudo-Decreases in Kidney Function
The New England Journal of Medicine
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2w ago
Selpercatinib leads to pseudo-decreased kidney function, which impairs tubular creatinine excretion. Cystatin C has no tubular secretion and may be a better marker for managing selpercatinib treatment ..read more
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Autism and Prenatal Exposure to Antiseizure Medication
The New England Journal of Medicine
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2w ago
In a population-based study, prenatal exposure to topiramate, valproate, or lamotrigine was linked with an increased risk of autism. After adjustment for confounders, only valproate exposure was linked with increased risk ..read more
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Hospitalization for Chronic Kidney Disease
The New England Journal of Medicine
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2w ago
In this trial involving patients with CKD, type 2 diabetes, and hypertension, the use of a personalized algorithm and practice facilitators in primary care clinics did not reduce hospitalization at 1 year ..read more
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Doctors and Guns
The New England Journal of Medicine
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1M ago
In this podcast episode, host Lisa Rosenbaum talks with two trainees whose lives and careers have been changed by educational debt, and to an economist who has a rather different take on the problem ..read more
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Vertical Integration and American Medicine
The New England Journal of Medicine
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1M ago
D. Khullar, L.P. Casalino, and A.M. Bond The stress imposed by structural and individual racism on Black people may contribute to the development of preeclampsia. But use of race to guide prevention-related decisions could be problematic ..read more
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CAR T-Cell–Mediated Responses in Recurrent Glioblastoma
The New England Journal of Medicine
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1M ago
CAR T-Cell–Mediated Responses in Recurrent Glioblastoma A novel CAR T-cell therapy directed at EGFRvIII with a secretable EGFR T-cell engager produced rapid responses in three patients with recurrent glioblastoma, but the responses were transient in two of the three ..read more
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