Medical Sciences, Vol. 12, Pages 21: Maternal Diabetes Mellitus and Neonatal Outcomes in Bisha: A Retrospective Cohort Study Medical Sciences doi: 10.3390/medsci12020021 Authors: Abdullah Alshomrany Elhadi Miskeen Jaber Alfaifi Hassan Alshamrani Abdulmohsen Alshahrani Background: Maternal diabetes mellitus (MDM) is associated with increased risks for adverse neonatal outcomes. However, the impact of MDM on neonatal outcomes in Bisha, a city in Saudi Arabia, is not well documented. This study aims to investigate the impact of MDM on neonatal outcomes in the Maternity and Children&rsquo ..read more

Medical Sciences, Vol. 12, Pages 20: Efficacy of Sorafenib-Based Therapies for Non-Small Cell Lung Cancer Medical Sciences doi: 10.3390/medsci12020020 Authors: Morgann Hendrixson Yevgeniy Gladkiy Anita Thyagarajan Ravi P. Sahu Lung cancer remains the leading cause of cancer-related deaths, with a poor prognosis. Of the two types, non-small cell lung cancer (NSCLC) is the major and most prevalent type and associated with low response rates to the current treatment options. Sorafenib, a multitargeted tyrosine kinase inhibitor used for various malignancies, gained attention for its potential effi ..read more

Medical Sciences, Vol. 12, Pages 18: Analysis of Endocrine and Inflammatory Markers in Preserved Ratio Impaired Spirometry Medical Sciences doi: 10.3390/medsci12020018 Authors: Fabíola Ramos Jesus Anna Clara Santiago Moraes Ingrid Lorena Neves da Silva Fabine Correia Passos Cristina Salles Margarida Célia Lima Costa Neves Gyselle Chrystina Baccan Chronic Obstructive Pulmonary Disease (COPD) is a disease of the lungs characterized by chronic airflow obstruction. Individuals with preserved ratio impaired spirometry (PRISm) may be at risk for developing COPD. This study aimed to characterize PRIS ..read more

Medical Sciences, Vol. 12, Pages 19: Automated Single-Sperm Selection Software (SiD) during ICSI: A Prospective Sibling Oocyte Evaluation Medical Sciences doi: 10.3390/medsci12020019 Authors: Debbie Montjean Marie-Hélène Godin Pagé Carmen Pacios Annabelle Calvé Ghenima Hamiche Moncef Benkhalifa Pierre Miron The computer-assisted program SiD was developed to assess and select sperm in real time based on motility characteristics. To date, there are limited studies examining the correlation between AI-assisted sperm selection and ICSI outcomes. To address this limit, a total of 646 sibling MII oo ..read more

Medical Sciences, Vol. 12, Pages 17: Exploring Brain and Heart Interactions during Electroconvulsive Therapy with Point-of-Care Ultrasound Medical Sciences doi: 10.3390/medsci12020017 Authors: Marvin G. Chang Tracy A. Barbour Edward A. Bittner Background: Electroconvulsive therapy (ECT) is a procedure commonly used to treat a number of severe psychiatric disorders, including pharmacologic refractory depression, mania, and catatonia by purposefully inducing a generalized seizure that results in significant hemodynamic changes as a result of an initial transient parasympathetic response that is ..read more

Medical Sciences, Vol. 12, Pages 16: Pituitary Adenoma in the Philippines: A Scoping Review on the Treatment Gaps, Challenges, and Current State of Care Medical Sciences doi: 10.3390/medsci12010016 Authors: Mykha Marie B. Tabuzo Mary Angeline Luz U. Hernandez Annabell E. Chua Patricia D. Maningat Harold Henrison C. Chiu Roland Dominic G. Jamora Background: Pituitary adenomas are benign brain tumors that impose a heavy burden on patients worldwide. The local burden of disease is yet to be established due to scarcity of data. In line with this, this study aims to present the challenges and gaps ..read more

Medical Sciences, Vol. 12, Pages 15: Survival Analysis of Male Patients with Brain Metastases at Initial Breast Cancer Diagnosis over the Last Decade Medical Sciences doi: 10.3390/medsci12010015 Authors: Jorge Avila Julieta Leone Carlos T. Vallejo José P. Leone Breast cancer in men represents approximately 1% of all breast cancer diagnoses. Among all patients with breast cancer, approximately 30% will develop brain metastases. Over the past decade, there have been multiple advances in the treatment of metastatic breast cancer; however, long-term outcomes of this presentation in male patients a ..read more

Medical Sciences, Vol. 12, Pages 14: Immunogenetic Background of Chronic Lymphoproliferative Disorders in Romanian Patients—Case Control Study Medical Sciences doi: 10.3390/medsci12010014 Authors: Maria Tizu Bogdan Calenic Ion Maruntelu Andreea Mirela Caragea Adriana Talangescu Larisa Ursu Corina Rotarescu Mariana Surugiu Alexandra Elena Constantinescu Ileana Constantinescu Background and Objectives: The implications of the genetic component in the initiation and development of chronic lymphoproliferative disorders have been the subject of intense research efforts. Some of the most i ..read more

Medical Sciences, Vol. 12, Pages 13: Association of Cannabis Use Disorder with Major Adverse Cardiac and Cerebrovascular Events in Older Non-Tobacco Users: A Population-Based Analysis Medical Sciences doi: 10.3390/medsci12010013 Authors: Avilash Mondal Sriharsha Dadana Poojan Parmar Maneeth Mylavarapu Qiming Dong Samia Rauf Butt Abeera Kali Bhaswanth Bollu Rupak Desai Background: Tobacco use disorder (TUD) adversely impacts older patients with established cardiovascular disease (CVD) risk. However, CVD risk in chronic habitual cannabis users without the confounding impact of TUD hasn&r ..read more

Medical Sciences, Vol. 12, Pages 12: Hereditary Renal Cancer Syndromes Medical Sciences doi: 10.3390/medsci12010012 Authors: Grigory A. Yanus Ekaterina Sh. Kuligina Evgeny N. Imyanitov Familial kidney tumors represent a rare variety of hereditary cancer syndromes, although systematic gene sequencing studies revealed that as many as 5% of renal cell carcinomas (RCCs) are associated with germline pathogenic variants (PVs). Most instances of RCC predisposition are attributed to the loss-of-function mutations in tumor suppressor genes, which drive the malignant progression via somatic inactivation ..read more