Identifying regulators of aberrant stem cell and differentiation activity in colorectal cancer using a dual endogenous reporter system
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Cas9-assisted biological containment of a genetically engineered human commensal bacterium and genetic elements
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Enhancing prime editor activity by directed protein evolution in yeast
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Topological barrier to Cas12a activation by circular DNA nanostructures facilitates autocatalysis and transforms DNA/RNA sensing
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Development of pathophysiologically relevant models of sickle cell disease and β-thalassemia for therapeutic studies
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Engineering self-deliverable ribonucleoproteins for genome editing in the brain
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Phage-assisted evolution of highly active cytosine base editors with enhanced selectivity and minimal sequence context preference
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Orthogonal inducible control of Cas13 circuits enables programmable RNA regulation in mammalian cells
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MEGA-CRISPR tool gives a power boost to cancer-fighting cells
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Domain-inlaid Nme2Cas9 adenine base editors with improved activity and targeting scope
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