The core part of oligonucleotide therapeutics is the carefully refined sequence of nucleotides that precisely binds the intended target. However, beyond this, there are a range of modifications and additions that are essential for the oligo to be effective in vivo. From getting where it’s needed to surviving ubiquitous nucleases, there are several challenges that a new therapeutic must overcome to successfully reach market.  In our new Toolbox blog series, we take a look at some of the key elements that were crucial to pioneering therapeutics as well as up-and-coming modifications that c ..read more

By Dusty Vyas, Senior Scientist at LGC Biosearch Technologies  ..read more

Updated : Friday, 31 January, 2025 @ 9:10 AM CT Just as enzymes are the workhorses of our cells, they continue to play a vital role on a much larger scale in manufacturing mRNA therapeutics. In vitro transcription has already enabled society to vaccinate the world against COVID-19 and there’s much more yet to come.  ..read more

An amino linker is perhaps the most versatile of all the modifications you can add to an oligonucleotide. Its primary amino group can attach a wide range of modifying chemical groups or immobilise the oligo on a solid surface. In this Know Your Oligo Mod blog post, we take a look at the diverse applications of amino linkers in research, diagnostics and therapeutics.  ..read more

Locked nucleic acids are an increasingly popular modification for tailoring and improving the performance of oligonucleotides in a variety of ways. As part of our Know Your Oligo Mod series, we look at how these modified bases work and how they are being used in qPCR probes and primers and in therapeutic development.   ..read more

Although PCR remains the gold-standard technique for molecular diagnostics assays, PCR misses the mark for applications that require fast results or environments where a sophisticated, cumbersome thermal cycler is impractical.1 As a result, a wide range of isothermal amplification techniques have emerged to bring rapid testing into clinical or field settings.  ..read more

Environmental DNA (eDNA) is genetic material extracted from the environment from the likes of water, soil, sediment, sand,snowand ice where there is no sign of biological source material. Thereis also an emerging field of eDNAanalysis from air for use in forensic investigations1.   ..read more

In our latest ‘Know your oligo mod’ post, we look at the impact of 5-methyl deoxycytidine – a modified nucleoside that increases the stability of the duplex and lowers the immune response to therapeutic oligos.  ..read more

By Austin Sheppe PhD, LGC Biosearch Technologies withcontributionsby Dusty Vyas, Senior Scientist LGC Biosearch Technologies.  ..read more

Our scientists and product specialists work in close collaboration with a diverse range of customers to find solutions that meet their precise needs. Our approach involves people across several teams to ensure that we are optimally positioned to understand the issues, devise solutions and make them readily available ..read more