TRIMming Tau Damage in Its Foxholes
The SENSible Blog
by Michael Rae
2M ago
Aberrant tau inside neurons is a key driver of Alzheimer’s disease, but nearly all the therapies in development to target it can only capture the small amount that floats outside of them. A new animal study reports impressive results in clearing aberrant tau inside neurons and rejuvenating cognitive function, opening up an important new front in damage-repair strategies for maintaining the aging brain. The post TRIMming Tau Damage in Its Foxholes appeared first on SENS Research Foundation ..read more
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Monkeying With the Clocks Via Metformin
The SENSible Blog
by Michael Rae
2M ago
A recent study claimed to find that metformin rejuvenated cognitive function in aging monkeys and lowered biological age on a nonhuman primate biological age clock. The details make the result unconvincing. The post Monkeying With the Clocks Via Metformin appeared first on SENS Research Foundation ..read more
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SENSible Question: Should We Engineer Our Mitochondria to be More Like Birds, or is That a Wild Goose Chase?
The SENSible Blog
by Michael Rae
2M ago
A supporter asks: Everyone knows that mitochondrial free radicals are a key driver of aging, and antioxidants don’t seem to offer any protection. Birds are supposed to have very clean-burning mitochondria, so should you maybe try to cut them off at the source by re-engineering our mitochondria to be more like those of birds? The post SENSible Question: Should We Engineer Our Mitochondria to be More Like Birds, or is That a Wild Goose Chase? appeared first on SENS Research Foundation ..read more
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Education Department October 2024 Updates
The SENSible Blog
by SRF
2M ago
Read more about SRF Education programs highlights and upcoming events. The post Education Department October 2024 Updates appeared first on SENS Research Foundation ..read more
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Education Department September 2024 Updates
The SENSible Blog
by SRF
2M ago
Read more about SRF Education programs highlights and upcoming events. The post Education Department September 2024 Updates appeared first on SENS Research Foundation ..read more
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SENSible Question: How Secure a Mitochondrial “Backup” is Allotopic Expression?
The SENSible Blog
by Michael Rae
2M ago
A supporter asks if “backing up” copies of the mitochondrially-encoded genes in the nucleus is really viable, granted free radical damage in the nucleus. We emphasize the many additional ways that the nuclear copies will be safer than the mitochondrial originals, that the “backup copies” can be backed up again, and how they and additional strategies will buy us time for even better solutions. The post SENSible Question: How Secure a Mitochondrial “Backup” is Allotopic Expression? appeared first on SENS Research Foundation ..read more
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Legs of Iron, Feet of Clay
The SENSible Blog
by Michael Rae
2M ago
Aging muscles lose strength above and beyond what would be expected from the mere loss of muscle mass. Accordingly, many drugs have been shown to stimulate muscle growth in older people, but the increased muscle mass consistently fails to translate into increased strength and physical function. To let people live independent lives for longer, we need damage-repair longevity therapeutics to repair the cellular and molecular damage that makes aging muscle dysfunctional. The post Legs of Iron, Feet of Clay appeared first on SENS Research Foundation ..read more
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Education Department August 2024 Updates
The SENSible Blog
by SRF
2M ago
Read more about SRF Education programs highlights and upcoming events. The post Education Department August 2024 Updates appeared first on SENS Research Foundation ..read more
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Job Opportunity: Associate Director of Marketing
The SENSible Blog
by SRF
2M ago
Job Type: Full-timeTitle: Associate Director of MarketingSalary: $100,000 – $140,000 per year SRF Overview: SENS Research Foundation is a non-profit organization that aims to develop new treatments for age-related diseases. Our mission is to bring an end to the suffering caused by age-related illnesses and provide people with longer, healthier lives. We have recently announced ... Read more The post Job Opportunity: Associate Director of Marketing appeared first on SENS Research Foundation ..read more
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Stephanie Dainow leads a panel at SALT iConnections Conference
The SENSible Blog
by SRF
2M ago
Watch Lifespan.io Executive Director and SENS Research Foundation Chief Business Officer Stephanie Dainow lead a panel entitled Longevity: How Programmable Biology is Helping Humans Live Healthier & Longer. The panel took place at the SALT iConnections Conference in New York City. The post Stephanie Dainow leads a panel at SALT iConnections Conference appeared first on SENS Research Foundation ..read more
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