Cell: Groundbreaking Personalized mRNA Vaccine Targets Glioblastoma
Creative Biolabs Vaccine Blog
by biovaccine
2w ago
In a first-of-its-kind human clinical trial involving four adult patients, an mRNA cancer vaccine developed by the University of Florida rapidly reprograms the immune system to attack glioblastoma, the most aggressive and deadly brain tumor. These results reflect the treatment outcomes of 10 pet dogs with naturally occurring brain tumors, whose owners agreed to participate in the treatment as they had no other options, as well as the results of a preclinical mouse model. This breakthrough will now be tested in a pediatric phase 1 clinical trial for the treatment of brain cancer. The findings w ..read more
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A Powerful Dual Anti-tumor Vaccine to Land!
Creative Biolabs Vaccine Blog
by biovaccine
2M ago
Gamma delta (γδ) T cells are a type of innate-like T cell that possess dual anti-tumor activities, capable of directly eliminating tumor cells and acting as immunostimulatory cells to enhance the body’s anti-tumor immunity. In a recent research report titled “Tumor vaccine based on extracellular vesicles derived from γδ-T cells exerts dual antitumor activities” published in the international journal Journal of Extracellular Vesicles, scientists discovered that extracellular vesicles (exosomes) derived from γδ-T cells not only exhibit direct anti-tumor effects but also, if developed into a tumo ..read more
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Review of Vaccine Adjuvant
Creative Biolabs Vaccine Blog
by biovaccine
4M ago
Vaccination is undoubtedly one of the most remarkable health achievements in human history. In just over two centuries, vaccines have enabled us to achieve extraordinary goals, such as eradicating smallpox, eradicating polio from most parts of the world, and dramatically reducing mortality and morbidity from many infectious diseases. Vaccination policies are the cornerstone of public health, and there is a strong emphasis on ensuring safe and effective vaccines. The effectiveness of the vaccine depends not only on the antigenic composition, but also on the adjuvants that are often used, stimul ..read more
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ACS Nano: Toll-Like Receptor 9 Agonist Boosts COVID-19 Vaccine
Creative Biolabs Vaccine Blog
by biovaccine
4M ago
The development of effective vaccines for infectious diseases is one of the most successful global health interventions ever. Although subunit vaccines largely depend on the selection of antigens and adjuvants, the exposure modes and time scales of the immune system are often overlooked. Adjuvants play a crucial role in enhancing the quality and efficacy of immune responses, but unfortunately, poor control over the delivery of many adjuvants can limit their efficacy and lead to off-target toxicity. Therefore, there is an urgent need to improve adjuvant delivery technologies to improve the effi ..read more
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Tumor Vaccine Enhancement Progress Revealed: What’s the Highlight?
Creative Biolabs Vaccine Blog
by biovaccine
5M ago
The trend in the field of cancer immunotherapy is the use of cancer vaccines. By using identified tumor antigens to stimulate the immune system, cancer vaccines can generate a specific immune response against tumor cells, thus causing the destruction of these cells and preventing recurrences and metastasis. Recently, a research team led by Zhao Xiao and Nie Guangjun at the National Center for Nanoscience and Technology of the Chinese Academy of Sciences proposed a strategy dubbed “peri-vaccination immune priming,” which involves enhancing the immune system through the use of bacterial nanopart ..read more
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Progress in Research on Nipah Virus Vaccine
Creative Biolabs Vaccine Blog
by biovaccine
7M ago
Recently, researchers from the Wuhan Institute of Virology, Chinese Academy of Sciences, published a research paper titled “Both chimpanzee adenovirus-vectored and DNA vaccines induced long-term immunity against Nipah virus infection” in npj Vaccines. The study holds the potential for further development into a candidate vaccine for the Nipah virus. Nipah virus disease is an acute and highly fatal zoonotic infectious disease caused by Nipah virus (NiV) infection, leading to diseases in both humans and animals that affect the central nervous and respiratory systems. Patients initially exhibit f ..read more
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Oncolytic Virus Enlisted as a Helper to Hance DC Vaccine’s Anti-tumor Potency
Creative Biolabs Vaccine Blog
by biovaccine
9M ago
Recently, a research paper titled “Oncolytic virus M1 functions as a bifunctional checkpoint inhibitor to enhance the antitumor activity of DC vaccine” was published in Cell Reports Medicine, a sub-journal of Cell. The study demonstrates that a novel oncolytic virus, M1 oncolytic vesicular stomatitis virus (OVM), can enhance the antitumor effect of DC vaccines by increasing the infiltration of CD8+ effector T cells in the tumor microenvironment. Mechanistically, tumor cells counteract DC vaccines through the SIRPα-CD47 immune checkpoint, and OVM can downregulate SIRPα in DCs and CD47 in tumor ..read more
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TLR9 Agonists Can Act as In-situ Anti-tumor Vaccines
Creative Biolabs Vaccine Blog
by biovaccine
9M ago
Osteosarcoma (OS) is a highly malignant mesenchymal tumor composed of cells that produce bone-like and immature bone tissue. The peak incidence occurs in the second decade of life after birth. Although relatively rare, the social impact of this tumor is particularly relevant. Unlike other cancers, the molecular genetics of OS progression and the role of its unique tumor microenvironment (TME)—the bone—remain largely unclear. While the TME has been extensively studied in other solid tumors to describe its role in tumor progression and, in part, in distant metastasis, research into tumor-stroma ..read more
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An Alzheimer’s Disease Vaccine Targeting Senescence-associated Glycoproteins Has Been Developed
Creative Biolabs Vaccine Blog
by biovaccine
9M ago
The American Heart Association’s Basic Cardiovascular Sciences Annual Conference in 2023, recently held in Boston, USA, featured a study indicating that a novel vaccine targeting inflammatory brain cells associated with Alzheimer’s disease may be a key to preventing or altering the course of the disease. As cells enter an aging state, they release pro-inflammatory factors, leading to various age-related diseases. Previous research identified a new protein, Senescence-Associated Glycoprotein (SAGP), as a biomarker for cellular aging. Inflammatory processes in cells can overactivate SAGP, and in ..read more
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Cell: Novel Vaccine Technology Generates More Antibodies Against SARS-CoV-2 in Mice
Creative Biolabs Vaccine Blog
by biovaccine
11M ago
In a recent study, the California Institute of Technology’s novel technology seeks to develop more effective vaccines, starting with SARS-CoV-2, the coronavirus that causes COVID-19. In mouse studies, this prototype vaccine produced five times more potent antibodies than the COVID-19 vaccines currently available. These antibodies generated by the new vaccine were effective against the original strain of SARS-CoV-2, the delta variant, and the omicron variant. The findings of this study were recently published in the journal Cell, under the title “ESCRT recruitment to SARS-CoV-2 spike induces vi ..read more
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