Chitin-mediated blockade of chitinase-like proteins reduces tumor immunosuppression, inhibits lymphatic metastasis and enhances anti-PD-1 efficacy in complementary TNBC models
Breast Cancer Research
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2d ago
Chitinase-like proteins (CLPs) play a key role in immunosuppression under inflammatory conditions such as cancer. CLPs are enzymatically inactive and become neutralized upon binding of their natural ligand chi ..read more
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Selective omission of sentinel lymph node biopsy in mastectomy for ductal carcinoma in situ: identifying eligible candidates
Breast Cancer Research
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2d ago
Sentinel lymph node biopsy (SLNB) is recommended for patients with ductal carcinoma in situ (DCIS) undergoing mastectomy, given the concerns regarding upstaging and technical difficulties of post-mastectomy SL ..read more
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Meeting Abstracts from the British Society of Breast Radiology annual scientific meeting 2023
Breast Cancer Research
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2d ago
This study investigated the feasibility of sentinel lymph node biopsy (SLNB) after neoadjuvant systemic therapy (NAST) in patients with initially high nodal burden ..read more
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Outcomes of sentinel node biopsy according to MRI response in an association with the subtypes in cN1–3 breast cancer after neoadjuvant systemic therapy, multicenter cohort study
Breast Cancer Research
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2d ago
This study investigated the feasibility of sentinel lymph node biopsy (SLNB) after neoadjuvant systemic therapy (NAST) in patients with initially high nodal burden ..read more
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Correction: Mcl-1 confers protection of Her2-positive breast cancer cells to hypoxia: therapeutic implications
Breast Cancer Research
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1w ago
Patients with hormone receptor positive breast cancer are recommended at least five years of adjuvant endocrine therapy, but adherence to this treatment is often suboptimal. We investigated longitudinal trends ..read more
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Clinical factors associated with patterns of endocrine therapy adherence in premenopausal breast cancer patients
Breast Cancer Research
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1w ago
Patients with hormone receptor positive breast cancer are recommended at least five years of adjuvant endocrine therapy, but adherence to this treatment is often suboptimal. We investigated longitudinal trends ..read more
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U2AF2-SNORA68 promotes triple-negative breast cancer stemness through the translocation of RPL23 from nucleoplasm to nucleolus and c-Myc expression
Breast Cancer Research
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1w ago
Small nucleolar RNAs (snoRNAs) play key roles in ribosome biosynthesis. However, the mechanism by which snoRNAs regulate cancer stemness remains to be fully elucidated ..read more
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Serum protein profiling reveals an inflammation signature as a predictor of early breast cancer survival
Breast Cancer Research
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1w ago
Breast cancers exhibit considerable heterogeneity in their biology, immunology, and prognosis. Currently, no validated, serum protein-based tools are available to evaluate the prognosis of patients with early ..read more
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BIRC5 expression by race, age and clinical factors in breast cancer patients
Breast Cancer Research
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3w ago
Survivin/BIRC5 is a proliferation marker that is associated with poor prognosis in breast cancer and an attractive therapeutic target. However, BIRC5 has not been well studied among racially diverse population ..read more
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Factors associated with engraftment success of patient-derived xenografts of breast cancer
Breast Cancer Research
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3w ago
Patient-derived xenograft (PDX) models serve as a valuable tool for the preclinical evaluation of novel therapies. They closely replicate the genetic, phenotypic, and histopathological characteristics of prima ..read more
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