A new perspective paper explores the current state and future directions of precision medicine in colorectal cancer (CRC). It outlines advancements in molecular testing and their implications for targeted and immunological therapies in CRC. This research is significant because it suggests pathways to more personalized treatment, potentially leading to higher survival rates and an improved quality of life for CRC patients ..read more

St. Jude Children's Research Hospital scientists have identified specific DNA variants in the non-coding regions of the genome contributing to chemotherapy resistance in acute lymphoblastic leukemia (ALL). The results guided the team to unravel the mechanism behind a previously unknown contributor to therapeutic resistance. The discovery was enabled by combining new technologies to overcome previous limitations in understanding the non-coding genome, which could be adapted to other types of cancer and diseases ..read more

Considered the most aggressive type of brain cancer, glioblastoma grows rapidly, destroying healthy tissue. Globally, approximately 300,000 people are diagnosed each year with glioblastoma ..read more

Tumor-resident microbiota in breast cancer promotes both the initiation and progression of cancer. However, the potential of targeting microbiota to enhance the efficacy of breast cancer treatment has not been comprehensively explored. In this study, researchers analyzed the microbial composition within breast tumors and identified a notable enrichment of ETBF in patients who exhibited resistance to taxane-based neoadjuvant chemotherapy ..read more

When cancer patients undergo chemotherapy, the dose of most drugs is calculated based on the patient's body surface area. This is estimated by plugging the patient's height and weight into an equation, dating to 1916, that was formulated from data on just nine patients ..read more

Mayo Clinic researchers have used a new approach to chemotherapy to more than double the typical survival rate for patients with stomach cancer and peritoneal metastasis, which is cancer that has spread to the lining of the abdominal cavity, according to a study published in the Annals of Surgical Oncology ..read more

In a study of patients who smoked when they were diagnosed with laryngeal cancer, those who quit smoking before starting chemotherapy or radiation responded better to treatment, were less likely to need their voice boxes surgically removed, and lived significantly longer than those who continued to smoke. The research, from the University of Oklahoma, is published in the journal Otolaryngology-Head and Neck Surgery ..read more

The U.S. Food and Drug Administration has approved Genentech's Alecensa (alectinib) as adjuvant treatment following tumor resection in patients with anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC ..read more

For patients with locally advanced prostate cancer, combined treatment with chemotherapy and hormonal therapy offers extended control of prostate-specific antigen (PSA) levels, compared to hormonal therapy alone, according to a study in the April issue of the Journal of Urology ..read more

Researchers at Peter Mac have found a new way to treat a form of leukemia that stops the disease in its tracks to prolong remission ..read more