A significant survival improvement finding for adults with newly diagnosed BCR::ABL1-negative B-cell precursor acute lymphoblastic leukemia appears in the New England Journal of Medicine. The practice-changing finding is from the randomized phase 3 study E1910, which evaluated blinatumomab immunotherapy in patients who were in remission and tested negative for measurable residual disease (MRD) after an initial round of chemotherapy ..read more

A team of researchers from Henan University of Science and Technology have introduced a novel method for improving drug testing for esophageal cancer (EC) using advanced three-dimensional (3D) cell culture technology. The authors created a tumor spheroid model on a chip by using inverse opal hydrogel scaffolds to better mimic the in vivo environment of tumors. This innovative platform enables more accurate assessment of chemotherapeutic agents by simulating the physiological conditions that cancer cells encounter in the body ..read more

A new compound developed by researchers at MUSC Hollings Cancer Center shows promise in overcoming chemotherapy resistance in triple-negative breast cancer—and could potentially be applied to fibrotic conditions like liver fibrosis or pulmonary fibrosis ..read more

A medication used to treat diabetic neuropathy may make chemotherapy treatments more effective for patients with lung cancer, according to new findings from the University of Missouri School of Medicine published in Clinical Cancer Research ..read more

In an editorial, published in Oncoscience titled, "Entering the golden age for antibody-drug conjugates in gynecologic cancer," researchers Michelle Greenman, Blair McNamara, Levent Mutlu, and Alessandro D. Santin from Yale University School of Medicine discuss gynecologic cancers ..read more

A model co-designed by a professor at Anglia Ruskin University is expected to reduce the need for chemotherapy in up to 38% of breast cancer patients who would previously have been advised to consider the treatment ..read more

Second- or third-line treatment with tisotumab vedotin is efficacious for patients with recurrent cervical cancer, according to a study published in the New England Journal of Medicine ..read more

The decision to treat patients with stage II colon cancer with adjuvant chemotherapy remains controversial. Therefore, there is an urgent need to identify reliable prognostic biomarkers that may be used to identify which patients would benefit from chemotherapy following surgery. In a study investigators have assessed the biomarker potential of RNAs in stage II colon cancer. Their findings appear in The American Journal of Pathology ..read more

A molecule called nidogen-2 may be a key driver of pancreatic cancer progression and metastasis, offering a promising new treatment approach for this aggressive cancer, according to a Garvan Institute study ..read more

Cancer's resistance to chemotherapy could be reversed by targeting lactate—the product that builds up as cancer cells convert nutrients to energy, according to new research published in Nature ..read more