STEMCELL Science News
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STEMCELL Science News (previously Connexon Creative) began as a personal email from STEMCELL Technologies founder Dr. Allen Eaves to several colleagues in the cell therapy community as a way to communicate the field's latest biomedical developments. We bring you our curated selection of high-impact publications, reviews, jobs, events, and news.
STEMCELL Science News
1d ago
Human mesenteric vascular endothelial cells and human umbilical vein endothelial cells were treated with Testo with or without a NOX4 inhibitor or NOX4 siRNA.
[American Journal of Physiology – Endocrinology and Metabolism]
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STEMCELL Science News
1d ago
Researchers investigated and characterized the effects of mechanical stimulation on the expression of angiogenic factors in retinal pigment epithelial cells both in vitro and in a mouse model.
[Disease Models & Mechanisms]
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Fibrostricturing Crohn’s Disease Is Marked by an Increase in Active Eosinophils in the Deeper Layers
STEMCELL Science News
1d ago
This study characterized immune cell distribution and protein expression in fibrotic and inflamed ileal tissue of Crohn’s disease patients. Immunologic, proteomic and histological data suggest inflammation and fibrosis were intertwined, with large overlap between both tissue types.
[Clinical And Translational Gastroenterology]
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STEMCELL Science News
1d ago
The authors discuss the general characteristics of age-related T cell immune alterations and the possible effects of aging T cells in various tissue structures in the human body.
[Immunity & Ageing]
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STEMCELL Science News
1d ago
COVID-OUT was a 2 × 3 randomized, placebo-controlled, double-blind trial that assessed metformin, fluvoxamine, and ivermectin; 999 participants self-collected anterior nasal swabs on day 1, day 5, and day 10.
[Clinical Infectious Diseases]
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STEMCELL Science News
1d ago
The authors summarize the status of therapeutic vaccines for herpes simplex virus, cytomegalovirus, and Epstein-Barr virus and proposes approaches for future development.
[Journal Of Clinical Investigation]
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STEMCELL Science News
1d ago
In vitro, a TNF-α-induced colonic organoid model was established to test the direct effect of sclareol on inflammation-induced intestinal barrier injury and inflammatory response. The Nrf2/NF-κB/MLCK signaling was analyzed to explore the mechanism of sclareo.
[International Immunopharmacology]
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STEMCELL Science News
1d ago
Transcriptomics and high dimensional flow cytometry revealed changes in murine tumor dendritic cells that not only mediated Treg infiltration after radiotherapy, but were associated with worse survival in human cancer datasets.
[Clinical Cancer Research]
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STEMCELL Science News
1d ago
The release of α, β-Methyleneadenosine 5′-diphosphate suppressed the adenosine generation via CD73 blockade, alleviating the impairment of adenosine to dendritic cells and suppressing regulatory T cells, and synergically stimulated the activity of T cells.
[Journal Of Nanobiotechnology]
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STEMCELL Science News
1d ago
Investigators highlighted the interaction between bipositive TAMs or cancer cells and T cells was predominantly focused on FXYD6+ T cells rather than regulatory T cells, whereas, FXYD6+ T cells were further identified as a group of novel immunosuppressive T cells.
[Journal For Immunotherapy Of Cancer]
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