Neonatal Research
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Follow important research in neonatology / newborn medicine from around the world. This blog is an attempt to help others in the field access important neonatal research literature without delay. Keith J. Barrington is a neonatologist and clinical researcher his particular research interests are in cardiovascular support, apnea and its treatment, the ethics of decision-making for high-risk..
Neonatal Research
5d ago
The standard method of pasteurization of donor breast milk, and I believe the only method approved by HMBANA (the human milk banking association of north america), is similar to what Louis Pasteur himself came up with a couple of centuries ..read more
Neonatal Research
2M ago
A new large RCT from PICUs in the UK randomly compared 2 saturation target ranges, 88-92 and >94%. Children <16 years of age being ventilated with supplemental oxygen were randomized within 6 hours of admission. The intervention stopped when the ..read more
Neonatal Research
3M ago
It was fairly recently that I deconstructed a truly terrible database analysis which claimed that neonatal mortality was dramatically increased among very preterm infants who received mother’s own milk (MoM) and donor human milk (DHM), without any formula or fortifier ..read more
Neonatal Research
3M ago
Yet another trial of PDA treatment and attempted closure with a null result. Baby-OSCAR was a UK multi-center masked RCT of ibuprofen treatment of 23 to <29 week infants who were screened with echocardiogram within the first 72 hours of ..read more
Neonatal Research
3M ago
I have written many times about the problems with classical composite outcomes in neonatal research. “Death or BPD”, “death or NDI”, or sometimes “death or NEC or Sepsis or BPD or severe IVH” have been used as a way of ..read more
Neonatal Research
4M ago
Two important new studies of the use of very early routine surfactant, compared to later selective surfactant if necessary. The first I will discuss is the one that didn’t seem to improve any important clinical outcomes (Murphy MC, et al ..read more
Neonatal Research
5M ago
The Lancet just published back-to-back articles from the iCOMP collaborative reporting the results of the Individual Patient Data Meta-analysis of trials of differing cord management techniques in preterm infants. There were 48 trials with a total of 7000 patients in the IPD which made 3 comparisons Delayed compared to immediate clamping, and each approach compared ..read more
Neonatal Research
5M ago
The word “probiotic” is defined rather vaguely as a micro-organism which has beneficial health impacts. I think it is obvious that there is a huge difference between fungi that are found in the intestinal microbiome of adults, and the lactic ..read more
Neonatal Research
5M ago
The recent statement from the AAP and a recent review article both state that probiotics only appear to be effective in babies over 1000g birthweight. This would be remarkable if it were true. I am trying to think of another ..read more
Neonatal Research
6M ago
After my recent post, about the study which suggested that donor milk was killing babies, I have been taking a deeper dive into the article, as I prepare a letter to the editor. Only 2 small subsets of the infants ..read more