Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. Background: The individual teratogenicity profiles of Lumacaftor and Ivacaftor are known, but the combined effects remain unexplored.Purpose: To evaluate the teratogenic profile of a combination of Lumacaftor and Ivacaftor in Sprague-Dawley Rats.Methods: This study adhered to the Committee for Control and Supervision of Experiments on Animals (CCSEA) and Organisation for Economic Co-operation and Development (OECD) guidelines. Sprague–Dawley rats were acclimated and housed individually under controlled conditions. A polygamous b ..read more

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. Background: Honey has been used for centuries for its medicinal benefits, where topical treatments in the folklore literature reported its beneficial role in treating different types of wounds. Despite its immense use in wound care, honey’s exact mechanism remains unclear.Purpose: The present study aimed to explore and abridge the gap between honey and its molecular wound healing mechanism.Methods: An extensive literature study has been performed where these activities can be explained due to phenolic compounds, nitric oxide, no ..read more

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. Background and Purpose: In alloxan-induced diabetic rats, this study sought to evaluate the hypoglycemic potential of the hydroalcoholic seed extract of Areca catechu, also referred to as areca nut, both as a stand-alone treatment and in combination with the diabetic drug gliclazide.Methods: The hot percolation method was used to produce the hydroalcoholic seed extract of A. catechu. Rats were given alloxan monohydrate and developed type II diabetes. The hydroalcoholic seed extract of A. catechu (1000 mg/kg p.o.) alone or in dif ..read more

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. Background: Cladophora goensis and Cladophora glomerata has been widely identified in the Indian Oceans. Marine algae have been identified as potential pharmacological agents useful in the treatment of diabetes, hypertension, infections, and cancers.Objectives: The present study aimed to evaluate the phytochemicals in C. goensis and C. glomerata using gas chromatography-mass spectroscopy (GC-MS), and to study the molecular interactions with cancer-related proteins using molecular docking techniques.Materials and methods: GC-MS a ..read more

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. Purpose: Forskolin is primarily found in the roots of the Coleus forskohlii plant, historically employed in Southeast Asian and Indian Ayurvedic medicine. Mast cells play a crucial role in fibrosis progression, yet their activation and inhibition in animal models are understudied; thus, we explored forskolin’s impact on kidney fibrosis.Materials and Methods: Forskolin was evaluated in a mouse model for stem cell factor-induced histamine release, and plasma histamine levels were measured using the enzyme-linked immunosorbent assa ..read more

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. Background: In the modern era of dentistry, natural and herbal alternatives are favored since they are renewable, have fewer adverse effects, and are cost-effective.Purpose: To assess the effectiveness of different intracanal medications in eliminating Enterococcus faecalis.Materials and Methods: In total, 50 single-rooted extracted teeth were decoronated at the cemento-enamel junction followed by the preparation of the canal. Then, in each of the presterilized samples, inoculum containing the E. faecalis was transferred and inc ..read more

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. Aim: This study aimed to determine the patterns of physical activity (PA) and its association with gender and academic year among undergraduate medical students of a tertiary care hospital in South India.Materials and Methods: A cross-sectional study was conducted among undergraduate medical students from August to October 2022 at a tertiary care teaching hospital in South India. PA was determined using the self-administered long form of the International Physical Activity Questionnaire (IPAQ). Statistical analysis was performed ..read more

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. Background: Colorectal cancer (CRC) is the third most common cancer worldwide causing approximately 10% of all cancer cases and is the second most frequent disease which is one of the leading causes of cancer-related fatalities. Traditional, complementary and alternative medicine (TCAM) refers to a broad range of health practices, therapies and products typically not part of the ‘conventional medicine’ system, and its use is substantial among the general population. The knowledge and awareness levels about TCAM and the use of al ..read more

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. Background: The first-trimester ultrasound assessment of nuchal translucency (NT) thickness has lately been recommended as the most helpful sign in early screening for prenatal chromosomal disorders. Increased foetal NT thickness between 11 and 13+6 weeks of gestation is a frequent phenotypic manifestation of chromosomal abnormalities as well as a variety of foetal deformities and genetic disorders.Purpose: At the moment, clinicians conduct the measurement manually. The measurement may take a long time to complete, requires high ..read more

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. Sleep is a crucial physiological process that plays an indispensable role in sustaining overall health and well-being. It is well known that various factors affect the multifaceted dimensions of sleep, from its underlying mechanisms or comorbidity to its profound impact on physical and mental health. Sleep disorders are very common, frequently underdiagnosed, and often overlooked. They are also linked to a wide range of illnesses and may significantly reduce the quality of life. There is strong evidence that chronic diseases are ..read more