Revealing MeCP2 Mechanism: Single-Molecule Insights into Epigenetic Regulation in Neurodevelopmental Disorders 
LUMICKS
by Chenlu Yu
2w ago
Explore the dynamic mechanism of MeCP2 in gene expression regulation, its complex interactions with DNA, and implications for Rett syndrome. This research brief uncovers groundbreaking research using single-molecule methods to understand MeCP2’s impact on disease pathology and potential therapeutic targets ..read more
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DNA Polymerase Undergoes Rapid Exchange and Retains Memory at Replication Forks 
LUMICKS
by Chenlu Yu
2M ago
Explore groundbreaking research on DNA polymerase exchange dynamics using the innovative C-Trap technology. Learn how this study offers new insights into DNA replication, polymerase activity, and the dynamic nature of the replisome. Ideal for both scientists and biotechnology professionals ..read more
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Cell Avidity uncovers critical binding mechanism impairing T-cell potency in the Tumor Microenvironment
LUMICKS
by Julian Ashby
3M ago
A key mechanism deployed by the TME is the upregulation of immune checkpoint molecules. The BTLA-HVEM interaction between CAR-T cells and tumor cells has emerged as a critical factor in T-cell inhibition and exhaustion. This article covers the excellent work of researchers at UPenn that deleted BTLA in CAR-T cells. This exhibited increased cell avidity to tumor targets when using CD19-targeting CAR-T cells leading to improved functionality in vivo ..read more
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Key mechanism in Fanconi Anemia pathway discovered with the C-Trap
LUMICKS
by Chenlu Yu
3M ago
Explore groundbreaking research on the FANCD2-I complex, central to the Fanconi anemia pathway, and its newly discovered mechanism in DNA repair and replication fork protection. This deep dive details the latest insights from recent studies, elucidating the complex's role in genomic stability and potential implications for cancer therapy ..read more
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Cell Avidity screening deployed by T cell pioneers to accelerate the identification of functional TCRs
LUMICKS
by Julian Ashby
4M ago
The TCR field continues to rely on a protracted preclinical selection process, which utilizes conventional assays such as affinity and peptide titrations that correlate poorly with T-cell functionality. Optimal TCR selection necessitates thorough preclinical characterization, prompting Carr et al., to focus on comprehensive cell-cell binding assessment to enhance preclinical decision-making ..read more
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Chromatin remodeling dynamics revealed at the single-molecule level in a recent pioneering study
LUMICKS
by Chenlu Yu
5M ago
Explore groundbreaking research on chromatin remodeling dynamics using the C-Trap, revealing 'hopping' and 'sliding' mechanisms of chromatin remodelers on DNA. Gain insights into the push-pull model and its implications for gene regulation and genomic integrity. Dive into the latest advancements in genomic research ..read more
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Securing Broken DNA Ends: PARP1’s Vital Role in Co-Condensation with DNA 
LUMICKS
by Chenlu Yu
5M ago
Explore how PARP1's involvement in DNA repair through condensate formation secures genetic integrity. Read this blog to understand the dynamics of DNA repair processes in real-time ..read more
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PARP1 secures broken DNA’s free ends via co-condensation with DNA  
LUMICKS
by Chenlu Yu
8M ago
DNA double-strand breaks (DSBs) are critical lesions that, if not properly repaired, can result in chromosomal rearrangements and genomic instability, underlining the importance of efficient repair systems in maintaining cellular and genetic health. The cell’s response involves a range of complex repair mechanisms such as homologous recombination and non-homologous end ..read more
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Unveiling Key Mechanisms in Kinetochore-Mediated Chromosome Segregation with the C-Trap
LUMICKS
by Chenlu Yu
10M ago
Dr. David Barford's study unveils kinetochore dynamics using LUMICKS C-Trap, shedding light on chromosome segregation mechanisms The post Unveiling Key Mechanisms in Kinetochore-Mediated Chromosome Segregation with the C-Trap appeared first on LUMICKS ..read more
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From Handshakes to Hugs: Embracing the Dynamics of Immunological Synapse Strength and Avidity 
LUMICKS
by Erica Fong
10M ago
What is an immune synapse?  An immunological (or immune) synapse is the interface between a cancer and an immune cell , which is formed in a highly stable, organized manner. The immunological synapse is composed of all intercellular interactions taking place at the interface between the interacting pair, including TCR clustering, co-receptor binding, cell-cell adhesion... The post From Handshakes to Hugs: Embracing the Dynamics of Immunological Synapse Strength and Avidity  appeared first on LUMICKS ..read more
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