Metagenomics has revolutionized our understanding of microbial communities, allowing us to delve into the network of microorganisms that shape our environment. Shotgun metagenomics, a widely used approach, enables us to reconstruct complex microbial communities at a high level of detail ..read more

Transcriptome analysis is a crucial step in understanding gene expression and regulation in biological and disease studies. However, traditional RNA sequencing methods have limitations in resolving complex transcript structures, such as those generated by alternative splicing. This is partly because these technologies use short read sequencing, which are less successful in resolving difficult sequencing regions ..read more

Thalassemia is a lesser-known genetic blood disorder that affects millions of people worldwide. While it may not be as familiar as other conditions, thalassemia has a significant impact health and well-being. Thalassemia affects the body's ability to produce hemoglobin, a crucial protein found in red blood cells. Hemoglobin is responsible for carrying oxygen from the lungs to the body's tissues and organs ..read more

Challenges to Diagnosing Parkinsonian Disorders Parkinsonian disorders, commonly referred to as parkinsonism, are a group of neurological conditions characterized by motor symptoms like those observed in Parkinson's disease (PD). These disorders share common features such as bradykinesia (slowness of movement), muscle rigidity, resting tremors, and postural instability ..read more

A Game-Changer in Clinical Genomics In recent years, the emergence of long-read sequencing (LRS) has enabled a more comprehensive and accurate view of the genome. This technology has overcome some of the limitations of short-read sequencing, including PCR bias, identification of structural variants, repetitive elements, and haplotyping ..read more

What Is Epigenetics? Epigenetics is considered a relatively new branch of genetic research. However, the concept dates back to the 1940s. Then, epigenetics was understood as a mechanism involving gene and gene-product interactions responsible for phenotypic expression.  ..read more

What Is the Tumor Microenvironment?  The tumor microenvironment (TME) is the environment and community of cells surrounding a tumor. By releasing signals, tumors can control their microenvironment and its interaction with the body’s blood vessels, immune cells, and tissues and organs. These signals help cancer cells to spread and become resistant to both immune attack and medical intervention.  ..read more

In the realm of cancer research, a remarkable transformation is underway. The use of proteomics on large scale cancer studies has the potential to uncover new biomarkers. In recent studies, blood proteomics has had promising results for detecting and identifying cancer. This technology will redefine early cancer detection, risk assessment, and the monitoring of diverse cancer subtypes ..read more

The Next Era of Sequencing Technology Third generation sequencing is the newest round of sequencing technologies hitting the omics market — and the future has never been brighter! Genetic research is now capable of analyzing individual cells, navigating very long and difficult DNA regions, and understanding cells in their native tissue context ..read more

Whole genome sequencing (WGS) and whole exome sequencing (WES) are two powerful next-generation sequencing technologies. Their use in research and clinical settings have changed our understanding of human genetics and its implications for health.  ..read more