Peripheral blood mononuclear cells (PBMCs) and cell pellets are common sources of DNA for human leukocyte antigen (HLA) typing in immune-related disease research. However, collecting these samples from donors can pose challenges that researchers should be aware of to ensure that the samples are of high quality and produce reliable and valuable data. Additionally, researchers may need to ship these samples to another laboratory for processing and analysis, and there are considerations that need to be taken into account for shipping. Challenges: Sample quality: The quality of the PBMC and cell ..read more

HLA typing is a laboratory test used to determine the type of human leukocyte antigen (HLA) that an individual has. HLA are proteins found on the surface of white blood cells, and they play an important role in how our immune system recognizes foreign substances such as bacteria or viruses. Knowing someone’s HLA type can help doctors make decisions about organ transplants, diagnose certain diseases, and understand why some people respond differently to medications than others. HLA typing is valuable because it helps to determine whether or not an individual may be a suitable donor for organ an ..read more

The HLA-DRB5 gene is a human leukocyte antigen gene located on chromosome 6. It is a part of the major histocompatibility complex (MHC) family, which helps the immune system recognize and respond to foreign substances. HLA-DRB5 is involved in presenting peptide antigens to T-cells for recognition. HLA-DRB5 is a polymorphic gene, meaning that it has many different variations. Each variation is associated with different levels of protection from certain diseases and with different responses to medical treatments. This variability makes it an important gene to study in terms of disease and treatm ..read more

HLA-G is a major histocompatibility complex (MHC) gene located on chromosome 6. The gene is a member of the HLA-A, -B, -C, -E, -F, and -G family of molecules, which are involved in the regulation of the immune system and other cellular functions. HLA-G is expressed at the surface of cells in a variety of tissues and organs, including thymus, spleen, testis, lymph nodes, and placenta. HLA-G plays a critical role in the development of the fetal-maternal interface and in the maintenance of pregnancy. It is essential for the immunological tolerance of the mother towards the fetus and for the devel ..read more

The HLA-DQB1 gene is an important component of the human leukocyte antigen (HLA) system, a group of genes that regulate the immune system. It is located on chromosome 6 in humans and encodes a class II major histocompatibility complex (MHC) molecule, known as the HLA-DQB1 molecule. The HLA-DQB1 gene plays a key role in antigen recognition and the regulation of immune responses. The HLA-DQB1 gene is composed of three exons and two introns, which span a total of 4.8 kb. The first exon encodes a leader peptide, while the second and third exons contain the coding sequences for the two domains of t ..read more

The HLA-DQA1 gene is a member of the HLA gene family, which is located on the short arm of chromosome 6. The gene encodes proteins that are involved in the immune response and are part of the major histocompatibility complex (MHC). HLA-DQA1 proteins are primarily expressed on the surface of antigen-presenting cells, such as macrophages, dendritic cells, and B cells. The proteins act as receptors for antigens and help the immune system recognize and respond to foreign substances. HLA-DQA1 is composed of two exons, which encode the alpha-1 and alpha-2 domains of the protein. The alpha-1 domain i ..read more

The HLA-DPA1 gene belongs to the human leukocyte antigen (HLA) family and is located on chromosome 6. It plays a key role in the immune system by helping the body to recognize and respond to foreign antigens. The gene provides instructions for making a protein that is a component of the major histocompatibility complex (MHC) class II molecules. These molecules help the body to distinguish between self and non-self antigens, and allow the immune system to mount an appropriate response. The HLA-DPA1 gene is part of a larger family of genes known as the HLA class II genes. This group of genes pla ..read more

The HLA-DRB4 gene is a member of the human leukocyte antigen (HLA) family, which is responsible for coding proteins that help the body’s immune system recognize and fight off foreign substances, such as viruses and bacteria. It is located on the short arm of chromosome 6 and encodes a transmembrane glycoprotein that is expressed on the surface of antigen-presenting cells. This gene is important for the development of the adaptive immune response, which is the body’s ability to recognize and respond to specific pathogens. The HLA-DRB4 gene is polymorphic, meaning that it can have different vers ..read more

HLA-DRB3 is a human leukocyte antigen (HLA) gene located on chromosome 6. It codes for a polymorphic cell surface glycoprotein known as the DRB3 molecule. This molecule is a member of the MHC class II family of immune-related proteins and is expressed on the surface of antigen presenting cells. HLA-DRB3 is involved in the recognition of foreign antigens by the immune system and plays an important role in the initiation and regulation of the adaptive immune response. This gene is highly polymorphic and variation in its sequence determines the specificity of the DRB3 molecule for different antig ..read more

The HLA-DRB1 gene is a major histocompatibility complex (MHC) gene located on chromosome 6 in humans. It is a polymorphic gene, meaning that it has many different forms that vary from person to person. The HLA-DRB1 gene encodes for the HLA-DRB1 protein, which is a type of MHC class II molecule. MHC molecules play an important role in the immune system by helping the body recognize and respond to foreign substances, such as viruses and bacteria. The HLA-DRB1 gene is a highly polymorphic gene, meaning that it has a large number of different alleles or variants. This is due to its high sequence v ..read more