Blog About Neuroblastoma Biology
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This blog is about neuroblastoma biology, its research challenges, and people and media perception of this disease.
Blog About Neuroblastoma Biology
3w ago
Few advancements in biomedical sciences hold as much promise for revolutionising cancer research as CRISPR-Cas9. This ground-breaking gene-editing tool has sparked a wave of innovation, offering precision and efficiency in manipulating the human genome in the fight against cancer. Now, what is it? CRISPR is basically an acronym for a very long name Clustered Regularly ..read more
Blog About Neuroblastoma Biology
3w ago
Huge congrats to a newly minted Dr Ellen King! She passed her PhD viva on April 9. This is a testimony to your dedication, strong will and hard work. May this PhD be the beginning of many more successful endeavours, Ellen! We thank examiners Prof Sally-Ann Cryan (RCSI) and Prof Joanne Lysaght (TCD) for the time and expertise ..read more
Blog About Neuroblastoma Biology
1M ago
How do researchers study cells? How do we get the nitty gritty? We use many methods to tag and chase various cell components. One of my favourites is fluorescent microscopy. It allows the use of nearly all spectrum of colours from blue to purple in one go. However, we prefer to narrow it down to ..read more
Blog About Neuroblastoma Biology
1M ago
At the Cancer Bioengineering Group, we use different types of scaffolds to mimic the 3D structure of tumours outside the body. We use these scaffolds to test new therapeutics and understand the tumour microenvironment. But I bet you didn’t think we had this in common with spiders? Spiders make their webs by producing silk from ..read more
Blog About Neuroblastoma Biology
1M ago
In humans, NANOG, SOX2, and OCT4 are transcription factors that maintain the undifferentiated state of embryonic stem cells (ESCs). NANOG was first discovered in 2003 by Chambers et al. and Mitsui et al. as a transcription factor in ESCs responsible for cellular self-renewal. More importantly, it enables continuous self-renewal of cancer stem cells, leading to ..read more
Blog About Neuroblastoma Biology
1M ago
Huge congrats to a newly minted Dr Ciara Gallagher! She defended her PhD on March 8 – International Women’s Day. Your enthusiasm and perseverance are truly fascinating! May this be the stepping stone towards a brighter future, Ciara! We thank examiners Dr Marie McIlroy (RCSI) and Prof Jan Škoda (Masaryk Uni) for the time and expertise ..read more
Blog About Neuroblastoma Biology
2M ago
Researchers use various methods, but I employ gene knockdown in my experiments. Basically, I use small RNA molecules that specifically target and degrade the mRNA of my gene of interest. This leads to a decrease in the corresponding protein levels, enabling me to observe the effects on neuroblastoma cell behaviour. I feel a bit like ..read more
Blog About Neuroblastoma Biology
2M ago
We are celebrating #ICCAD2024 with a Bake Sale and a Quiz. To earn a piece of cake, you have to answer a question correctly! Have a look at some ..read more
Blog About Neuroblastoma Biology
3M ago
For our next little series introducing a different thing in science and how it works every week, I decided to focus on classifiers. With artificial intelligence becoming more and more prominent in our daily lives as of late, I thought this would be a good lead into the explicitly science-focused topics to come. So, what ..read more
Blog About Neuroblastoma Biology
4M ago
So, the new year has just started! What would it bring us? Who will we meet? What will we write in my notebook? Will we be busy bees as usual or experience a new level of business/laziness? Let’s check this in 12 months ..read more