Claudia H. Kawas, M.D., addresses Alzheimer's disease and related conditions in older adults, noting the challenge of accurate diagnosis and the resemblance of other brain conditions to Alzheimer's. She introduces "resistance" and "resilience," explaining how some individuals remain cognitively intact despite brain changes. Kawas suggests declining dementia risk due to improved vascular health management, emphasizing the complexity of cognitive decline and the need for further research. Series: "Brain Channel" [Health and Medicine] [Science] [Show ID: 39532 ..read more

Alison Moore, M.D., M.P.H., F.A.C.P., discusses the keys to healthy aging: staying active, mentally engaged, socially connected, having a positive outlook, and being resilient. Dr. Moore emphasizes the importance of these factors for a long and healthy life. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 39347 ..read more

Carla Kim, Ph.D., explains how aging impacts lung cell biology and its potential to reshape our understanding of diseases, including lung cancer. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39254 ..read more

Ronald DePinho, M.D., explains how telomerase, typically linked to telomere maintenance, serves as a transcriptional co-activator in the brain. Epigenetic repression of TERT, the gene for telomerase, occurs with aging, contributing to aging hallmarks like cellular senescence and inflammation. DePinho's team developed a compound that reactivates TERT, which, when administered to mice, reverses age-related changes. It restores cognitive function, reduces amyloid plaque, and alleviates inflammation. This suggests that maintaining TERT levels can counteract age-related cognitive decline and neurod ..read more

Leonard Zon, M.D., discusses cutting-edge research on the intricate relationship between macrophages, stem cells, and the development of leukemia using the zebrafish model. He delves into the fascinating interactions between these cell types, highlighting the role of a "don't eat me" signal and the influence of the leukemic niche. Through cellular barcoding and single-cell RNA sequencing, he unveils a potential therapeutic target which may offer promising insights into treating leukemia by disrupting the stromal activities that support it. Zon showcases the power of zebrafish models in advanci ..read more

What drives human resilience? How can we harness resilience to improve the lives of older adults? Anthony J.A. Molina, Ph.D., shares how geroscience research is leading the way to longer, healthier, and more fulfilling lives. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 39125 ..read more

Explore aging's impact on well-being with Barton Palmer, Ph.D. Learn how resilience, optimism, and social connections shape happiness in later life. Discover practical interventions like mindfulness and value-driven actions. Understand the role of positive psychology and spirituality. Delve into adapting interventions for cognitive changes. Gain valuable insights into navigating challenges and fostering well-being as we age. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 38972 ..read more

Having a skilled primary care clinician will go a long way to maintaining your health and wellness. In this program on primary care basic, Dr. Robert B. Baron discusses the best practices in how to measure blood pressure, treatment goals, diet, lifestyle and medications. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 38791 ..read more

Engaging in everyday physical activity can influence brain and cognitive health. Zvinka Z. Zlatar, Ph.D., shares how physical activity can potentially reduce risk for Alzheimer's disease and other cognitive issues. She reviews the current excercise recommendations for older adults and how digital devices can help us reach our goals. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 38693 ..read more

Aging research has come a long way in the past few decades, and scientists are now starting to understand the biology of aging. Anthony J.A. Molina, Ph.D.shares the latest findings in the field of geroscience, or the study of how to delay the onset of age-related diseases and extend healthy lifespan. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 38634 ..read more