<div><p paraid="738692707" paraeid="{ae8e1f42-cbc3-470c-add6-9a35b06d7954}{223}"><b>Commentary Contributed by Bruce Hellman, uMotif&nbsp;</b></p></div><div><p paraid="143519371" paraeid="{ae8e1f42-cbc3-470c-add6-9a35b06d7954}{231}"><b>April 19, 2024</b> | The proliferation of mobile technology&mdash;including multiple generations of progressively smarter phones, tablets, watches, and other devices&mdash;has set the stage for similar types of eClinical innovation. However, the two types of technologies have not progressed a ..read more

<div><p paraid="1623219036" paraeid="{f0e9d117-3c5c-4fe2-9284-4d0300c136dd}{176}"><b>By Deborah Borfitz</b></p></div><div><p paraid="1249861563" paraeid="{f0e9d117-3c5c-4fe2-9284-4d0300c136dd}{186}"><b>April 16, 2024</b> | Study sponsors making choices about if, when, and how to include brain monitoring in their clinical studies do not often ground those choices in science or optimize for subject safety and trial de-risking, according to clinical neurophysiologist Dona Murphey, M.D., Ph.D., chief scientific officer for Lifelines Neuro ..read more

<div><p paraid="1942633362" paraeid="{c7dd6e0b-92ca-4b03-ad2a-6d10fe2536af}{167}"><b>Commentary Contributed by Isaac B. Agbugblah and Ernest K. Boamah, Mursi Biosciences&nbsp;</b></p></div><div><p paraid="2145373069" paraeid="{c7dd6e0b-92ca-4b03-ad2a-6d10fe2536af}{189}"><b>April 12, 2024</b> | Africa faces a dual healthcare challenge with the persisting burden of infectious diseases and the escalating prevalence of non-communicable diseases (NCDs). This shifting paradigm underscores the urgent need for African research sites to br ..read more

<div><p paraid="457367137" paraeid="{5a9bc9e9-3d8f-4b6e-b3ac-5f5f2f574896}{188}"><b>By Deborah Borfitz&nbsp;</b></p></div><div><p paraid="1776791368" paraeid="{5a9bc9e9-3d8f-4b6e-b3ac-5f5f2f574896}{198}"><b>April 10, 2024</b> | When it comes to research on amyotrophic lateral sclerosis (ALS), every stakeholder&mdash;most especially patients&mdash;knows time is of the essence. From diagnosis to death, life expectancy from the debilitating neuromuscular disease can be two years or less. &ldquo;The time people give us is ..read more

<div><p paraid="1743046718" paraeid="{f31f8113-8a7b-49d7-8821-6c7a75b5098e}{174}"><b>By Deborah Borfitz&nbsp;</b></p></div><div><p paraid="1933303450" paraeid="{f31f8113-8a7b-49d7-8821-6c7a75b5098e}{186}"><b>April 9, 2024</b> | Scientists in the Georgia Tech Integrated Cancer Research Center (ICRC) are proposing a new, more realistic approach to diagnosing cancer that provides a probabilistic statement about the likelihood of developing it, much like how cholesterol tests are used to assess heart disease risk. Probabilities are ba ..read more

<div><p paraid="1124371427" paraeid="{a36b33eb-8ff9-4077-8ada-bb1ddc667dea}{178}"><b>By Deborah Borfitz</b></p></div><div><p paraid="513566464" paraeid="{a36b33eb-8ff9-4077-8ada-bb1ddc667dea}{188}"><b>April 2, 2024 </b>| For roughly half of patients with recurrence of often-deadly glioblastoma multiforme (GBM), their tumors are characterized by cells that look a lot like healthy neurons. The mimicry trick was discovered by proteomics, which has opened a view to tumor alterations unavailable through genetics alone, according to Antonio ..read more

<div><p paraid="2005868580" paraeid="{c975517c-5fb9-4ef5-a024-ece4212bee32}{175}"><b>By Deborah Borfitz</b></p></div><div><p paraid="351065736" paraeid="{c975517c-5fb9-4ef5-a024-ece4212bee32}{185}"><b>March 28, 2024</b> | A machine learning method dubbed A-PLUS (Alu Profile Learning Using Sequencing) recently demonstrated its ability to pick up cancers earlier and with smaller blood draws than is required for whole genome sequencing. This makes possible a future where people might get annual blood draws to check for cancer based on th ..read more

<div><p xml:lang="EN-US" lang="EN-US" paraid="1281602576" paraeid="{bbc494e6-8a8c-4684-bfc2-e97d0ad10409}{35}"><b>By Clinical Research Team&nbsp;&nbsp;</b></p></div><div><p xml:lang="EN-US" lang="EN-US" paraid="1888560166" paraeid="{bbc494e6-8a8c-4684-bfc2-e97d0ad10409}{52}"><b>March 27, 2024</b> | SEQSTER has been selected by the Multiple Sclerosis Association of America (MSAA) for its patient-centricity, 1-Click Records, and cutting-edge longitudinal health record; Owkin adds immunology to Sanofi collaboration; Thermo Fisher ..read more

<div><p paraid="910523845" paraeid="{d8ec363a-c613-4e11-bf35-36300facf0a5}{242}"><b>By Clinical Research Staff&nbsp;&nbsp;</b></p></div><div><p paraid="1625311741" paraeid="{d8ec363a-c613-4e11-bf35-36300facf0a5}{250}"><b>March 26, 2024</b>| Sionna Therapeutics plan to develop a first-in-class small molecules designed to fully restore the function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein by stabilizing the first nucleotide-binding domain (NBD1); Capstan Therapeutics is advancing CPTX2309, the co ..read more

<div><p paraid="210886043" paraeid="{bbbe4111-85d7-4e01-8c95-a3a66b787d37}{185}"><b>By Deborah Borfitz&nbsp;</b></p></div><div><p paraid="1054033448" paraeid="{bbbe4111-85d7-4e01-8c95-a3a66b787d37}{195}"><b>March 21, 2024</b> | A revolution is underway in the diagnostics world that is reminiscent of what transpired in the computing field before the advent of PCs and smartphones, according to Mehdi Javanmard, CEO and cofounder of RizLab Health (Princeton, New Jersey). The unimagined possibilities of today will come from democratizi ..read more